The present context, with an ongoing pandemic situation, war and climate change, seems to play a critical role in both the peoples’ perception of their quality of life, and the acquisition and development of social and emotional competencies. In this study, our goal was to assess the relationship between social and emotional competencies and peoples’ quality of life in a Portuguese sample. Participants were 1139 individuals living in Portugal, aged between 16 and 85 years old, who were mostly (73%) female. An online protocol for data acquisition was used, which included sociodemographic characterization, the Portuguese version of the scale of Social and Emotional Competencies (SEC-Q) and the World Health Organization Quality of Life (WHOQOL-BRIEF). Correlation analysis and a canonical correlation were performed, with results showing a high association between the dimensions of social and emotional competencies and peoples’ quality of life. Two significant canonical roots were extracted, and the results show that the first is characterized by internal factors, linking psychological health and self-management and motivation, and the second root evidences the external factors, linking social relations and environment with social awareness and pro-social behavior.