Einfluß der Cholezystektomie auf die exkretorische Pankreasfunktion des Menschen<sup>*</sup>

Mm, Forell; Otte, M.; Lechelt, B; Røder, Ole Christian; Stahlheber, H.; Gr, Thurmayr; Thurmayr, R.

doi:10.1055/s-0028-1106935

Cited by 3 publications

(2 citation statements)

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“…Moreover, in cholecystectomized patients-with a continuous bile flow into the duodenum-trypsin secretion was significantly higher than in healthy controls with bile-free duodenal aspirates (14). Furthermore, the initial pancreatic response to secretin and CCK was significantly reduced in cholecystectomized patients (15,16). This effect could also be restored by intraduodenal application of exogenous bile.…”

Section: Effect Of Bile and Bile Salts On Basal And Hormonally Stimulmentioning

confidence: 58%

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl¹,

Lehnert²

1992

Scandinavian Journal of Gastroenterology

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Section: Effect Of Bile and Bile Salts On Basal And Hormonally Stimulmentioning

confidence: 58%

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl¹,

Lehnert²

1992

Scandinavian Journal of Gastroenterology

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“…Forell et al (42,43) observed that the increase in pancreatic bicarbonate and enzyme output after exogenous administration of bile is a dose-dependent process. In patients who underwent cholecystectomy and who had a normal contraction of the gallbladder preoperatively, the early pancreatic enzyme response to intravenous cholecystokinin and secretin was significantly lower postoperatively than before the operation (40). These results indicate that under normal conditions the presence of bile in the duodenum participates in the regulation of pancreatic enzyme secretion.…”

Section: Bile Bile Saltsmentioning

confidence: 74%

Pancreatic Secretory Response to Intestinal Stimulants: A Review

1987

Scandinavian Journal of Gastroenterology

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Singer MV. Pancreatic secretory response to intestinal stimulants. Scand J Gastroenterol 1987, 22(suppl 139), 1-13In humans and many laboratory animals, protein digestion products such a s peptides and amino acids and fat digestion products such as fatty acids and monoglycerides are potent intestinal stimulants of pancreatic cnzymc secretion. The pancreatic enzyme response to these intestinal stimulants is related to thc pcrfuscd load (amount per unit time) rather than to concentration. Both neural and hormonal pathways mediate the enzyme response t o thesc intestinal stimulants. Enteropancreatic, cholinergic, vago-vagal reflexes are probahly the most important mediators of the enzyme response to low loads of amino acids and fatty acids; hormones, such ;IS cholecystokinin, seem to be the major mediators of the response to high loads of amino acids and fatty acids. Under physiological conditions it is prohahly thc interplay o f neural and hormonal mechanisms which regulates the pancreatic response to these stimulants. Gastric acid is the major regulator of postprandial pancreatic bicarbonate secretion. Secretin released by HCI is probably the most important physiological hormonal mediator of postprandial pancreatic bicarbonate secretion; its effect heing potentiated by extrinsic (vagal) and intrinsic (intrapancreatic) cholincrgic nerves and rclease of other hormones, such as cholecystokinin. , vagal and splanchnic; pancreatic bicarbonate and enzyme response; sccretin Pro6 sirarsklinik, Hufelandstr. 55, 0-4300 Essen I , FRC Dr. Manfred V . Singer, Ahteilung Casrroenrrologie, Medizinische Unioer-Scand J Gastroenterol Downloaded from informahealthcare.com by University of Sydney on 01/03/15 For personal use only. Scand J Gastroenterol Downloaded from informahealthcare.com by University of Sydney on 01/03/15 For personal use only. No effect No effect No effect Depressed (low loads) Scand J Gastroenterol Downloaded from informahealthcare.com by University of Sydney on 01/03/15For personal use only.

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