Einfluss von Dopexamin und Iloprost auf die Plasma-Disappearance-Rate von Indozyaningr�n bei Patienten im septischen Schock

Birnbaum, Jürgen; Lehmann, Christian; Taymoorian, Kasra; Krausch, Dietmar; Wauer, Helmar; Gründling, Matthias; Spies, Claudia; Kox, Wolfgang J.

doi:10.1007/s00101-003-0580-1

Cited by 10 publications

(2 citation statements)

References 34 publications

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“…Other methods of advanced monitoring, such as ICG clearance or pH i measurements, do not play a significant role. ICG clearance, for example, shows benefits in the monitoring of liver dysfunction, but is only indicated in multiple organ failure (29,30).…”

Section: Discussionmentioning

confidence: 99%

Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post‐operative cardiac surgery patients in Germany: results from a postal survey

Kastrup

Markewitz

Spies

et al. 2006

Acta Anaesthesiol Scand

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126

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Hemodynamic monitoring and the variability in clinical practice with regard to volume replacement, transfusion triggers and the use of vasopressors/inotropes in cardiac surgery patients tend to follow the results of traditional experience rather than current scientific knowledge. Guidelines are therefore necessary to help to improve the standards of intensive care after cardiac surgery and thus the outcome of patients.

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Section: Discussionmentioning

confidence: 99%

Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post‐operative cardiac surgery patients in Germany: results from a postal survey

Kastrup

Markewitz

Spies

et al. 2006

Acta Anaesthesiol Scand

Self Cite

126

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“…Clinical data has validated PDR ICG as a marker of hepatic function and perfusion [14]. Previous studies detected a strong association between PDR ICG and outcome in critically ill patients [15].…”

Section: Introductionmentioning

confidence: 99%

Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting - an observational study

et al. 2009

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IntroductionDuring cardiac surgery with cardiopulmonary bypass (CPB) haemodilution occurs. Hepatic dysfunction after CPB is a rare, but serious, complication. Clinical data have validated the plasma-disappearance rate of indocyanine green (PDR ICG) as a marker of hepatic function and perfusion. Primary objective of this analysis was to investigate the impact of haemodilutional anaemia on hepatic function and perfusion by the time course of PDR ICG and liver enzymes in elective CABG surgery. Secondary objective was to define predictors of prolonged ICU treatment like decreased PDR ICG after surgery.Methods60 Patients were subjected to normothermic CPB with predefined levels of haemodilution anaemia (haemotacrit (Hct) of 25% versus 20% during CPB). Hepatic function and perfusion was assessed by PDR ICG, plasma levels of aspartate aminotransferase (ASAT) and α-GST. Prolonged ICU treatment was defined as treatment ≥ 48 hours.ResultsLogistic regression analysis showed that all postoperative measurements of PDR ICG (P < 0.01), and the late postoperative ASAT (P < 0.01) measurement were independent risk factors for prolonged ICU treatment. The predictive capacity for prolonged ICU treatment was best of the PDR ICG one hour after admission to the ICU. Furthermore, the time course of PDR ICG as well as ASAT and α-GST did not differ between groups of haemodilutional anaemia.ConclusionsOur study provides evidence that impaired PDR ICG as a marker of hepatic dysfunction and hypoperfusion may be a valid marker of prolonged ICU treatment. Additionally this study provides evidence that haemodilutional anaemia to a Hct of 20% does not impair hepatic function and perfusion.Trial registration[ISRCTN35655335]

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ICG Clearance Monitoring in ICU Patients

Levesque

Saliba

2009

Intensive Care Medicine

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Einfluss von Dopexamin und Iloprost auf die Plasma-Disappearance-Rate von Indozyaningr�n bei Patienten im septischen Schock

Abstract: Dopexamine and iloprost have a positive effect on the plasma disappearance rate of ICG and therefore have a protective effect on splanchnic perfusion and liver function, respectively.

Cited by 10 publications

References 34 publications

Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post‐operative cardiac surgery patients in Germany: results from a postal survey

Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post‐operative cardiac surgery patients in Germany: results from a postal survey

Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting - an observational study

ICG Clearance Monitoring in ICU Patients

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