1910
DOI: 10.1002/cber.191004303100
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Einwirkung von Wasserstoffsuperoxyd auf Thebain, Morphin und dessen Äther

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Cited by 28 publications
(9 citation statements)
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“…The concentration of all drugs has been expressed in terms of the base. Morphine-N-oxide was prepared according to the method of Freund & Speyer (1910). Solutions for injection were freshly prepared each day by dissolving the MNO in 0.1 N HCl and adjusting to pH 5 with NaOH.…”
Section: Teratogenic Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…The concentration of all drugs has been expressed in terms of the base. Morphine-N-oxide was prepared according to the method of Freund & Speyer (1910). Solutions for injection were freshly prepared each day by dissolving the MNO in 0.1 N HCl and adjusting to pH 5 with NaOH.…”
Section: Teratogenic Activitymentioning
confidence: 99%
“…They suggested that MNO was an intermediate metabolite in the breakdown of morphine. Earlier reports suggested that MNO was without analgesic activity (Freund & Speyer, 1910;Rosenthaler, 1933; Keil, Schmidt & Giinther, 1933;Anton, Theiss & Weissig, 1935;Braenden, Eddy & Halbach, 1955). However, Fennessy (1968) found it to have a weak analgesic activity which was markedly potentiated when it was administered with either amiphenazole or tacrine to rats and mice.…”
mentioning
confidence: 95%
“…The concentration of amiphenazole has been expressed in terms of the salt, and those of morphine, morphine-N-oxide and tacrine in terms of base. Morphine-N-oxide was prepared according to the method of Freund & Speyer (1910). Solutions for injections were made by dissolving it in 0.1 N-HCI with adjustment to pH5 with NaOH; they were freshly prepared on the day of each experiment.…”
Section: Drugsmentioning
confidence: 99%
“…Morphine-N-oxide has been reported to possess little or no analgesic activity (Freund & Speyer, 1910;Rosenthaler, 1933;Keil, Schmidt & Gunther, 1933;Anton, Theiss & Weissig, 1935). It is difficult, however, to evaluate these reports for they contain insufficient information concerning the species and numbers of animals used, the routes of administration and whether morphine-N-oxide was given as a solid, suspension or solution.…”
mentioning
confidence: 99%
“…However, a few synthetics of this type are now known and have recently been investigated (14) in detail; their behavior towards alkaline hydrogen peroxide is quite different from that of porphyroxine. Furthermore, hydrogen peroxide is known to react with codeine, yielding both an N-oxide (15) and a dimolecular compound (16). One would therefore have expected to find these also among the final products in the reaction of hydrogen peroxide with porphyroxine, which is said to constitute the most important proof for the structure assigned to the alkaloid.…”
mentioning
confidence: 99%