EKSTRAK DAUN SEMBUNG &lt;em&gt;(Blumea balsamifera)&lt;/em&gt; MEMPERBAIKI HISTOLOGI TESTIS TIKUS WISTAR YANG DIINDUKSI PAKAN TINGGI LEMAK

Widhiantara, I Gede; Permatasari, Anak Agung Ayu Putri; Siswanto, Ferbian Milas; Dewi, Ni Putu Eny Sulistya

doi:10.29122/jbbi.v5i2.2868

Cited by 10 publications

(8 citation statements)

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“…As reported by Dantas et al (52) thatfoodcontaminated by synthetic herbicides such as Ametryn can cause reproductive performance disorders (decreased Leydig cells, lipidperoxidation, Superoxide dismutase, catalase) and animal life (male Wistar rats). Consumption of foods high in fat can also cause a decrease in the number and diameter of Leydig cells in male Wistar rats (53) .…”

Section: Food Has Been Reported To Reduce the Number Ofmentioning

confidence: 99%

Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review

I Gede Widhiantara,

Anak Agung Ayu Putri Permatasari,

I Wayan Rosiana

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Male fertility can be defined as the ability of the male reproductive system to impregnate a woman, while infertility is the condition of a married couple who have been married for one year or more and have had sexual intercourse regularly or without using contraception but do not have a pregnancy or offspring. About 10% of married couples experience infertility. The main organ of male reproduction is the testes because in the testes the process of forming spermatozoa and the hormone testosterone occurs. The hormone testosterone plays a direct role in the continuity of spermatogenesis. Testosterone is produced through a series of steroidogenesis mechanisms in testicular Leydig cells. Several factors influence the course of steroidogenesis such as Leydig cells, steroidogenesis proteins, related genes to the influence of free radicals. These factors are closely related to diet and lifestyle. This study is important to understand in efforts to prevent infertility in men.

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Section: Food Has Been Reported To Reduce the Number Ofmentioning

confidence: 99%

Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review

I Gede Widhiantara,

Anak Agung Ayu Putri Permatasari,

I Wayan Rosiana

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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“…Leydig cells play an important role in testosterone hormone regulation. According to Widhiantara et al [31], Rats fed with high-fat feed in the long period will experience a decrease in the number of Leydig cells caused by hyperlipidemia. Hyperlipidemia can trigger to increase ROS compounds, disruption of the hypothalamus-pituitary axis, thereby decreasing LH secretion and disrupting the stimulation of Leydig cells to produce testosterone [28,32].…”

Section: Testosterone Concentrationsmentioning

confidence: 99%

Identification of Active Compounds of Kepok Banana Peel and the Effect on Testosterone Concentration in Male Rats with High-Fat Diet

et al. 2020

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Our body needs an adequate supply of antioxidants to maintain physiological functions. Antioxidant compounds are found in natural plants, including inside of kepok bananas peel. This research was conducted to determine the potential of kepok banana peels to maintain testosterone concentration in male rats (Rattus norvegicus) with a high-fat diet. This study used 20 male rats 2.5-3 months old, which grouped into 5 groups: normal group given standard feed (K1), negative control group given high-fat diet (K2), positive control group given high-fat diet and simvastatin (K3), high-fat diet group and banana peel extract administered at 100 mg/kg BW (K4), and high-fat diet group and banana peel extract administered at 200 mg/ kg BW (K5). The blood serum was collected after 60 days of the treatment. The blood serum testosterone levels were measured by enzyme-linked immunosorbent assay (ELISA) method at a wavelength of 450 nm. The major findings of this study were that there is a significant difference between testosterone concentrations by the K4 group compared to K2 and K5 groups (p<0,05). The result suggests that the dose 100 mg/kg BW of banana peel extract has the potential to maintain the testosterone concentration in male rats with a high-fat diet.

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“…Dislipidemia adalah kelainan dari metabolisme lipoprotein, yaitu overproduksi ataupun defisiensi dari lipoprotein tertentu. Dislipidemia dapat bermanifestasi sebagai peningkatan konsentrasi kolesterol total, trigliserida, dan low-density lipoprotein (LDL) serta penurunan high-density lipoprotein (HDL) dalam darah (Widhiantara, Permatasari, Siswanto, & Dewi, 2018). Keadaan ini sering diikuti dengan sindrom metabolik.…”

Section: Pendahuluanunclassified

“…Ekstrak daun Jati Belanda (Guazuma ulmifolia Lamk) mengandung flavonoid sebesar 651,41 mg/100g QE. Flavonoid telah terbukti dapat memperbaiki profil lipid darah dan mencegah kerusakan testis pada tikus yang dislipidemia (Amani, Moazen, Shahbazian, Ahmadi, & Jalali, 2014;Widhiantara, Permatasari, et al, 2018). Flavonoid merupakan kelompok senyawa fenol yang terbesar ditemukan di alam yang berpotensi sebagai antioksidan dan mempunyai bioaktivitas sebagai obat (Widhiantara, Arunngam, & Siswanto, 2018).…”

Section: Hasil Dan Pembahasanunclassified

Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia

Hidajat

Aman

Sukoco

et al. 2020

J. Sains Tek. Peter.

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The purpose of this study was to prove that the administration of Jati (Guazuma ulmifolia Lamk) leaves extract improves the lipid profile of dyslipidemic male Wistar rats. Subjects were 20 rats (Rattus norvegicus), male, Wistar strain, dyslipidemia (total cholesterol ≥ 200 mg dl-1), aged 2 months old, weighing 180-200 grams. The control group (10 rats) were given a placebo of 3 ml aquadest (P0) and the treatment group was given extracts of the Jati (Guazuma ulmifolia Lamk) leaves extract of 25 mg kg-1 BW (P1). Before and after treatment for 14 days, total cholesterol, triglyceride, LDL, and HDL levels were examined. The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, LDL, and HDL levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p<0.05) and an increase in HDL levels (p<0.05). The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats. It was necessary to compare the effectiveness of Jati leaves extract with synthetic dyslipidemia drugs used in the community such as statin.

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EKSTRAK DAUN SEMBUNG <em>(Blumea balsamifera)</em> MEMPERBAIKI HISTOLOGI TESTIS TIKUS WISTAR YANG DIINDUKSI PAKAN TINGGI LEMAK

Cited by 10 publications

References 0 publications

Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review

Steroidogenesis Mechanism, Disruption Factor, Gene Function, and Role in Male Fertility : A Mini Review

Identification of Active Compounds of Kepok Banana Peel and the Effect on Testosterone Concentration in Male Rats with High-Fat Diet

Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia

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