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Abstract

Captopril has been administered to eight healthy male subjects by means of a pulsatile delivery system that was designed to release the drug in the colonic region of the intestine. The gastrointestinal transit and pulsatile release were followed using gamma scintigraphy. A pulsatile capsule system with release after a nominal 5-hr period was found to perform reproducibly in vitro and in vivo. In six of the eight subjects, the drug was delivered to the colon, and in the remaining two subjects, to the terminal ileum. Measurable blood levels of free captopril were found in three subjects. Variable instability of the drug in the distal intestine is suggested as a possible reason for the lack of absorption of the drug in the majority of subjects.

Double-layered microsphere based dual growth factor delivery system for guided bone regeneration

“…31 Another big challenge for drug delivery systems is to maintain the bioactivity of loaded drugs especially for those protein drugs. [32][33][34][35] In this study, the novel alginate core-shell microspheres were prepared by electrospray to achieve a differential delivery of growth factors and also maintain the biological functions. As shown in Fig.…”

Formulation, optimization and evaluation of mucoadhesive microspheres of captopril

“…Short biological half life of 1-2 hours is one of the most important drawback of captopril. Therefore, the development of a once-daily captopril oral formulation would be a significant advantage for patient compliance [3,4].…”

Electrospun Micelles/Drug‐Loaded Nanofibers for Time‐Programmed Multi‐Agent Release

“…In some degree, these release systems enable a temporally and spatially regulated release manner of dual drugs. Furthermore, time‐programmed release, such as pulsatile release, time‐controlled explosion, sigmoidal release is a critical issue to improve the delivery effect. However, in practical application of the systems, there still exist many problems.…”