Electrospun Micelles/Drug‐Loaded Nanofibers for Time‐Programmed Multi‐Agent Release

Abstract

Combined therapy with drugs of different therapeutic effects is an effective way in the treatment of diseases and damaged tissues or organs. However, how to precisely control the release order, dose, and time of the drugs using vehicles is still a challenging task. In this work, for the first time, a study to develop a nanoscale multi-drug delivery system based on polymer micelle-enriched electrospun nanofibers is presented. The multi-drug delivery system is achieved, first, by the fabrication of hydrophobic curcumin encapsulated micelles assembled from biodegradable mPEG-PCL copolymer and, second, by the blending of the micelle powder with hydrophilic doxorubicin in polyvinyl alcohol solution, followed by simply electrospinning this combination. Due to the different domains of the two drugs within the nanofibers, the release behaviors show a time-programmed release, and can be temporally and spatially regulated. In vitro tumor cell inhibition assay indicates that the delivery system possesses great potential in cancer chemotherapy.

Micelle‐Coated, Hierarchically Structured Nanofibers with Dual‐Release Capability for Accelerated Wound Healing and Infection Control

“…[19] Alternatively, to achieve time-programmed multi-agent release upon dissolution, hydrophilic, biodegradable micelles, loaded with anticancer agents, were included within hydrophilic NFs via electrospinning. [20] However, the aforementioned efforts focused either on bone regeneration or anti-cancer applications and did not involve topographical modification of NF surfaces through micellar attachment. Furthermore, bioactive agents incorporated into NFs via electrospinning are exposed to harsh organic solvents and control over their release kinetics is limited.…”

Photo‐ and pH‐ Dual‐Responsive β‐Cyclodextrin‐Based Supramolecular Prodrug Complex Self‐Assemblies for Programmed Drug Delivery

“…[38] Wang et al prepared ar edox/pH dual-responsivem agnetic supraparticle@P(MAA-Cy) [P(MAA-Cy) = poly(methylacrylic acid-co-N,N-bis(acryloyl)cystamine)] drug-delivery system to adjust the releaser ates of paclitaxel (TXL) and DOX. [40] Therefore, multi-responsives upramolecular prodrug self-assemblies for programmed response drug delivery are necessaryfor advanced drug delivery. [40] Therefore, multi-responsives upramolecular prodrug self-assemblies for programmed response drug delivery are necessaryfor advanced drug delivery.…”

“…[37] This strategy was recently utilized to release different drugs in different environments and to adjust the release rates under different stimuli conditions. [38][39][40] For example, Liu et al used reduction and UV dual-responsive polymeric prodrug self-assembliest or ealize the sequential release of siRNA and DOX. [38] Wang et al prepared ar edox/pH dual-responsivem agnetic supraparticle@P(MAA-Cy) [P(MAA-Cy) = poly(methylacrylic acid-co-N,N-bis(acryloyl)cystamine)] drug-delivery system to adjust the releaser ates of paclitaxel (TXL) and DOX.…”

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

“…25 Recently, a series of implantable electrospun nanofibrous LDDSs have shown superior therapeutic performance in cancer treatment due to their unique strength in ensuring therapeutic dosage levels at the tumor site for extended period while maintaining low systematic drug exposure. 26–28 However, the drugs loaded at the surface of LDDSs intend to present burst releasing at the initial stage of drug delivery. Direct incorporation of such biomolecules (drugs) within the polymeric matrix during synthesis may induce drug degradation owing to organic solvents or heating procedures involved.…”