Elective haemodialysis increases exhaled isoprene

Abstract

Isoprene concentration was higher in the exhaled air of patients after HD as compared with values before HD. Large interindividual variability existed in isoprene kinetics. Oxidative stress appears to be an unlikely cause for this rise. An alternative hypothesis is an influence of respiratory variables on isoprene exhalation based upon Henry's law constant. We therefore propose to perform online monitoring of isoprene exhalation by PTR-MS during the HD session to investigate the possible influence of respiratory variables.

Quantitative breath analysis of volatile organic compounds of lung cancer patients

“…As shown in Fig. 1, N,N-dimethylacetamide (C 4 H 9 NO, retention time 9.02 min) and phenol (C 6 H 6 O, retention time 11.33 min) were two of the most abundant VOCs in human breath besides acetone (C 3 H 6 O, retention time 1.71 min) and isoprene (C 5 H 8 , retention time 1.87 min) [32,33]. The two VOCs were considered as pollutants [30].…”

Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications

“…Abnormal breath isoprene levels are related to end-stage renal failure and increases in isoprene levels have been associated with oxidative stress. However, this assumption has not been proved by the work of Lirk and co-workers [65]. Little focus has been given, thus far, to the relationships between breath levels and the underlying systemic concentrations.…”

Detection of Volatile Malodorous Compounds in Breath: Current Analytical Techniques and Implications in Human Disease

“…Another study found that hemodialysis increases isoprene concentration in breath [130]. The study employed 50 patients undergoing dialysis and reported that isoprene levels were significantly higher after the hemodialysis than before the procedure.…”