Electric field effects on Nano-Scale bio-membrane of spherical cells

Lajevardipour, Alireza; Sepangi, H. R.

doi:10.1016/j.physa.2008.10.011

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Furthermore, the polarization of the cell membrane under an external electric field exerts local forces (Krassowska and Neu 1994) which cause various deformational regimes of cell elongation (Kononenko and Shimkus 2000) and can transform the spherical cell into prolate ellipsoids if the membrane surface is sufficiently flexible (Neek-Amal et al 2009). However, for simplification, they are generally considered as spherical particles (Kadaksham et al 2005;Urdaneta and Smela 2007).…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Dielectrophoretic-activated cell sorter based on curved microelectrodes

Khoshmanesh

Zhang

Tovar-Lopez

et al. 2009

Microfluid Nanofluid

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This article presents the numerical and experimental analysis of a dielectrophoretic-activated cell sorter (DACS), which is equipped with curved microelectrodes. Curved microelectrodes offer unique advantages, since they create strong dielectrophoretic (DEP) forces over the tips and maintain it over a large portion of their structure, as predicted by simulations. The performance of the system is assessed using yeast (Saccharomyces cerevisiae) cells as model organisms. The separation of the live and dead cells is demonstrated at different medium conductivities of 0.001 and 0.14 S/m, and the sorting performance was assessed using a second array of microelectrodes patterned downstream the microchannel. Further, microscopic cell counting analysis reveals that a single pass through the system yields a separating efficiency of *80% at low medium conductivities and *85% at high medium conductivities.

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