Electroacupuncture Versus Pelvic Floor Muscle Training Plus Solifenacin for Women With Mixed Urinary Incontinence: A Randomized Noninferiority Trial

Liu, Baoyan; Liu, Yan; Qin, Zongshi; Zhou, Kehua; Xu, Huangfang; He, Liyun; Li, Ning; Su, Tongsheng; Sun, Jianhua; Yue, Zeng-Hui; Zang, Zhiwei; Zhang, Wei; Zhao, Jiping; Zhou, Zhongyu; Lian, Ling; Wu, Dongning; Wu, Jiani; Zhou, Jing; Pang, Ruoming; Wang, Yan; Liu, Jia; Yu, Jinming; Liu, Zhishun

doi:10.1016/j.mayocp.2018.07.021

Cited by 30 publications

(54 citation statements)

References 29 publications

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“…The evidence around the role of acupuncture for UI is increasing, and positive trials exist for the management of SUI . However, the explicit mechanisms and factors affecting such efficacy remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…All patients in the other group received PFMT once per week for weeks 1‐12 and once every four weeks for weeks 13‐36, plus oral solifenacin 5 mg daily over the entire 36 weeks. Detailed study methods and results of the MUI trial have been published . Of the 250 patients in the EA group, a total of 132 S‐MUI patients, including 43 obese and 89 non‐obese subjects were identified in the secondary analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed study methods and results of the MUI trial have been published. 17,23 Of the 250 patients in the EA group, a total of 132 S-MUI patients, including 43 obese and 89 non-obese subjects were identified in the secondary analysis.…”

Section: The Ea Vs Pfmt Plus Solifenacin For Mui Trialmentioning

confidence: 99%

“…The evidence around the role of acupuncture for UI is increasing, and positive trials exist for the management of SUI. 16,17,36 However, the explicit mechanisms and factors affecting such efficacy remain unknown. Causing muscle contraction and simulating PFMT by stimulating S3 via BL33 (Zhongliao) and the pudendal nerve via BL35 (Huiyang) have been considered as a plausible explanation of acupuncture for SUI.…”

Section: International Consultation On Incontinence Questionnaire-shortmentioning

confidence: 99%

“…In a randomised controlled trial of EA vs sham EA (SA) for SUI, we found that EA involving the lumbosacral region led to a greater reduction in the amount of urine leakage than SA. In the second trial of EA vs PFMT plus solifenacin for MUI, we observed that EA involving the same acupoints was not inferior to PFMT plus solifenacin at decreasing the 72‐hours incontinence episode frequency (IEF) for S‐MUI. However, the two trials did not specifically analyse whether obesity impacted the outcomes of EA for SUI or S‐MUI.…”

Section: Introductionmentioning

confidence: 99%

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Comparing the effect of electroacupuncture treatment on obese and non‐obese women with stress urinary incontinence or stress‐predominant mixed urinary incontinence: A secondary analysis of two randomised controlled trials

Wang

Liu

et al. 2019

Int J Clin Pract

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Objective To explore whether obesity patients with a body mass index (BMI) of ≥25 kg/m2 who suffer from stress urinary incontinence (SUI) or stress‐predominant mixed urinary incontinence (S‐MUI) show less improvement in urinary incontinence (UI) symptoms after electroacupuncture (EA) treatment compared with non‐obese counterparts. Methods This study was a secondary analysis of existing data. About 252 SUI patients and 250 S‐MUI patients treated with the same EA regimen were assigned to one of the two groups: the obesity group for BMI ≥25 kg/m2 and the non‐obesity group for BMI <25 kg/ m2. The primary outcome was the proportion of treatment responders, defined as patients exhibiting a ≥50% reduction in 72‐hours incontinence episode frequency, as measured by a 72‐hours bladder diary at week 6 compared with baseline. Results Of the 1004 randomised women, 129 obese women (86 SUI and 43 S‐MUI) and 255 non‐obese women (166 SUI and 89 S‐MUI) treated with EA were included in a secondary analysis. The primary outcome was that 58.3% (74/127) of patients in the obesity group and 60.7% (150/247) of patients in the non‐obesity group (difference 0.55%; 95% confidence interval, −10.01 to 11.11; P = .919) responded to treatment. Conclusion This study suggests that EA treatment may safely improve UI symptoms in both obese and non‐obese patients, regardless of BMI category. Additionally, obesity status may not affect the efficacy of EA treatment on SUI or S‐MUI among Chinese women.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: The Ea Vs Pfmt Plus Solifenacin For Mui Trialmentioning

confidence: 99%

Section: International Consultation On Incontinence Questionnaire-shortmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparing the effect of electroacupuncture treatment on obese and non‐obese women with stress urinary incontinence or stress‐predominant mixed urinary incontinence: A secondary analysis of two randomised controlled trials

Wang

Liu

et al. 2019

Int J Clin Pract

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Acupuncture for treating overactive bladder in adults

Hargreaves

Baker

Barry

et al. 2022

Cochrane Database of Systematic Reviews

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Acupuncture in addition to standard conservative treatment for overactive bladder; a feasibility trial for a randomized controlled study

Hargreaves

Harding

Clarkson

2021

Neurourology and Urodynamics

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Aims This study aims to assess the feasibility of an randomized controlled trial (RCT) to test treatment efficacy of acupuncture for symptoms of overactive bladder syndrome (OAB), a common long‐term condition with physical, psychological, social and sexual consequences. Methods A total of 30 participants were recruited and randomized to either standard conservative management for OAB or standard conservative management plus acupuncture. Standard care consisted of individually tailored advice regarding bladder health, pelvic floor exercises and lifestyle adjustments. The intervention group received 6 sessions of acupuncture over an 8‐week period. Outcomes measured included adherence to the study protocol, recruitment rate, participant attrition rate and adverse events. A 3‐day bladder diary and Incontinence Questionnaire—short form questionnaire were used to assess symptoms. The ICEpop CAPability measure for Adults measure was used to assess well‐being. Outcomes were collected at baseline, after 8 weeks of intervention and 6 weeks after completing intervention. An exit questionnaire captured participant experience data. Results Comparison of the two groups at baseline did not detect statistically significant differences in demographics and symptom profile. A total of 23 participants completed all study proceedures. Recruitment was completed in 11 months, quicker than anticipated. No serious adverse events occurred; minor adverse events were recorded in 11/114 (9.6%) treatments. A total of seven participants failed to complete one or more study proceedures with an overall attrition rate of 23.3%. Conclusions Most participants completed all aspects of the study and found the protocol acceptable. The interventions appear safe and well tolerated. The concept of a large‐scale RCT with a similar protocol was proven and appears feasible based on this pilot work.

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Electroacupuncture Versus Pelvic Floor Muscle Training Plus Solifenacin for Women With Mixed Urinary Incontinence: A Randomized Noninferiority Trial

Cited by 30 publications

References 29 publications

Comparing the effect of electroacupuncture treatment on obese and non‐obese women with stress urinary incontinence or stress‐predominant mixed urinary incontinence: A secondary analysis of two randomised controlled trials

Comparing the effect of electroacupuncture treatment on obese and non‐obese women with stress urinary incontinence or stress‐predominant mixed urinary incontinence: A secondary analysis of two randomised controlled trials

Acupuncture for treating overactive bladder in adults

Acupuncture in addition to standard conservative treatment for overactive bladder; a feasibility trial for a randomized controlled study

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