Electroanalysis of Mefenamic Acid in Pharmaceutical Formulation and Spiked Biological Fluids on Modified Carbon Nanotube Electrode

Abstract

The development of an electrochemical sensor for determination of mefenamic acid is the main purpose of this work. The determination was performed in pharmaceutical formulations, spiked urine and human plasma samples by multi-walled carbon nanotube-graphite/Ag (MWCNTs-G/Ag) electrode. Hence some voltammetric methods were investigated to determination of mefenamic acid. The dependence of peak currents and potentials on pH and voltammetric parameters was investigated for the optimization of electrochemical method. The porous structure of MWCNTs-graphite mixture improves the electroactive surface area. As a result, a remarkable increasing in the peak currents was observed. The prepared mixture displayed an electrocatalytic effect in anodic oxidation of mefenamic acid with a sensitivity augmentation. The best electrochemical response was obtained from square wave voltammetry with a sensitive peak at 0.68 V in pH 5. The prepared electrode showed good standard calibration curves during 3 days over a wide concentration range with RSD values ranging from 1.6-8%. The limits of quantification and detection were 50 and 16 ng/mL, respectively.

Simultaneous Determination of Trace Mefenamic Acid in Pharmaceutical Samples via Flow Injection Fluorometry

“…5 Several analytical methods for the determination of MFA in pure and pharmaceutical samples have already RESEARCH ARTICLE been developed and reported. These analytical methods, include electrochemical analysis, 6 spectrophotometry, 7,8 chromatography, 9,10 atomic absorption spectrometry, 11 fluorescence spectrometry, 12 nuclear magnetic resonance spectroscopy, 13,14 and flow injection analysis. 15,16 To improve the sensitivity, accuracy, and simplicity of an analytical method, the flow injection technique is combined with a fluorometric method.…”