Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes

Wang, Joseph; Tangkuaram, Tanin; Loyprasert, Suchera; Vázquez-Alvarez, Terannie; Veerasai, Waret; Kanatharana, Proespichaya; Thavarungkul, Panote

doi:10.1016/j.aca.2006.07.084

Cited by 95 publications

(48 citation statements)

References 15 publications

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“…Detection of organic compounds based on electrochemical principle, such as amperometry [1 -7], potentiometry [8] and voltammetry [4,7], have been continuously developed. To achieve high sensitivity and short analysis time electrodes are often modified with nanomaterials, e.g.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Nanoporous Copper Film for Electrochemical Detection of Glucose

et al. 2009

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A nanoporous copper film was fabricated on a copper wire by electrodeposition of copper/zinc alloy and chemically etching of zinc. The surface morphology was investigated by SEM. When applied to detect glucose in an amperometric flow injection system the porous copper electrode provided 12 times higher sensitivity than solid copper. It could be continuously used up to 50 times (%RSD ¼ 5.7). Different preparations of the porous film provided reproducible responses (P < 0.05). Detection of glucose in E. coli cultivation medium compared well with spectrophotometric technique (P < 0.05). This simple technique can produce a nanoporous electrode with good performances and can easily be applied to other metals and analytes.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Nanoporous Copper Film for Electrochemical Detection of Glucose

et al. 2009

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“…Because the film was produced upon the evaporation of DMF, there was little control of film morphology leading to agglomeration of the MWCNTs. Recent improvements by Wang and co-workers include a combination carbon nanotube/ruthenium oxide electrode [35]. Wu et al reported that the stability of MWCNT films for the detection of small biomolecules is improved by addition of a fatty acid such as dihexadecyl phosphate to an aqueous suspension of MWCNTs [36].…”

Section: Introductionmentioning

confidence: 99%

A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber

Snider

Ciobanu

Rue

et al. 2008

Analytica Chimica Acta

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We have developed a multiwalled carbon nanotube/dihydropyran (MWCNT/DHP) composite sensor for the electrochemical detection of insulin in a microfluidic device. This sensor has been employed for physiological measurements of secreted insulin from pancreatic islets in a Cytosensor® previously modified to be a multianalyte microphysiometer (MAMP). When compared with other established electrochemical insulin sensors, the MWCNT/DHP composite film sensor presented improved resistance to fluidic shear forces, while achieving enhanced electrode kinetics. In addition, the preparation of the composite film is straightforward and facile with a self-polymerizing monomer, DHP, used to add mechanical stability to the film. The sensor film was able to detect insulin concentrations as low as 1 µM in the MAMP during calibration experiments. The MWCNT/DHP composite sensor has been successfully used for the direct detection of insulin secreted by islets in the microphysiometer.

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“…99 The enhanced electrocatalytic activity towards insulin was attributed to a lowered oxidation potential and enhanced sensor response. The RuOx/CNT-modified carbon electrodes exhibited a wide linear dynamic range of 10-800 nM and limit of detection of 1 nM.…”

Section: Nanomaterialsmentioning

confidence: 99%

Electrochemical Sensors

2013

Encyclopedia of Biophysics

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This review covers publications related to electrochemical sensors that appeared in print during the years 2006 and 2007. The focus of the review is on the development of electrochemical sensing principles including potentiometric and chronopotentiometric sensors, reference electrodes, voltammetric sensors, and electrochemical biosensors.References were collected by searching electrochemical sensor-related work using ACS SciFinder and ISI Science Citation Index. In addition, the tables of contents of several analytical journals were reviewed manually to identify relevant articles. Only original and review articles written in English were considered. Patents, book chapters or book series, and conference proceedings or abstracts were not considered for this review. The number of references was limited to 200 and as a result only a fraction of relevant work is covered. Specifically, the review was written to focus on fundamental aspects of electrochemical sensor research emphasizing new chemical concepts and not simply the application of electrochemical sensors. On the basis of these guidelines, several hybrid systems whereby electrochemical detection schemes were combined with a separation technique such as microdialysis, electrophoresis, chromatography, and lab-on-a-chip were not included in this review.We ask that our readers note that our review is not a comprehensive coverage of the above topics, but rather a snapshot of research conducted over the past two years. Obviously, electrochemical sensor research is still expanding and of interest to a number of disciplines beyond traditional chemistry. As such, it was not possible to cover all manuscripts published. We apologize to the authors of manuscripts that were not included in this review. POTENTIOMETRIC SENSORS ReviewsBakker and Pretsch published a broad review on modern potentiometry describing techniques for improving sensor performance, miniaturizing sensor platforms, and expanding the application of potentiometric sensors for environmental trace analysis and biosensing (98 citations). 1 Likewise, Pretsch provided a general overview on ion-selective electrodes (ISEs) focusing on improving detection limits and understanding non-classical (i.e., non-equilibrium) potentiometry for monitoring clinical relevant polyions such as heparin and protamine (81 citations). 2 De Marco et al. reviewed ISE methodologies for the analysis of trace metals and anions (e.g., F − , CN − , NO 3 − , NO 2 − , and Cl − ) in environmental samples. 3

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Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes

Cited by 95 publications

References 15 publications

Fabrication of Nanoporous Copper Film for Electrochemical Detection of Glucose

Fabrication of Nanoporous Copper Film for Electrochemical Detection of Glucose

A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber

Electrochemical Sensors

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