Electrochemical Behavior of 4-Aminophenazone Drug at a Graphite Pencil Electrode and Its Application in Real Samples

Abstract

An analytical method for the determination of 4-aminophenazone using cyclic and differential-pulse voltammetry has been developed. The oxidation process was shown to be irreversible over the pH range 3.0−11.2. The dependence of the current on pH, concentration, and scan rate was investigated to optimize the experimental conditions for the determination of 4aminophenazone. The number of electrons transferred in the oxidation process was calculated, and a probable oxidation mechanism was proposed. In the range of (1.0 × 10 −6 )−(1.6 × 10 −5 ) M, the current measured by differential-pulse voltammetry as a function of the concentration of 4-aminophenazone with a detection limit of 0.458 × 10 −7 M with good selectivity and sensitivity exhibited a good linear relationship. The proposed method was applied to the determination of 4-aminophenazone in a real sample.

Poly(thionine)-carbon nanotube modified carbon film electrodes and application to the simultaneous determination of acetaminophen and dipyrone

“…Higher sensitivities were obtained in [12,14], but with narrower linear ranges. Detection limits were similar to those in [12] and much lower than in [9]; although they were higher than those in [13,42,43] ( [13,43] using stripping voltammetric techniques), in these cases, the upper linear range limits were only 2.6 μM [13,43] and 16 μM [42].…”

Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine

“…The detection limits reported at different analytical methods for AAP related dipyrone derivative drugs are tabulated in Table 1 . The proposed method was better than other reported electrochemical methods [31] , [38] , [54] , [55] , [56] .

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“…Nano-Riboflavin-modified glassy carbon electrode(voltammetry) 0.0502 μM [55] 4. Titanium phosphate/nickel hexacyanoferrate mod graphite electrode(voltammetry) 3.75×10 −4 M [56] 2) 4-Aminophenazone Graphite pencil electrode(voltammetry) 0.45×10 −7 M [38] 3) 4-Aminoantipyrine MWCNT-CTAB modified glassy carbon electrode 1.63×10 −10 M Present work …”

“…Different methods have been reported for the determination of AAP including liquid and gas chromatography, spectrophotometric method [29] , [30] , [31] , liquid chromatography/mass spectrometry [32] , capillary electrophoresis [33] , solid phase spectrophotommetry [34] , different HPLC methods [35] , [36] , [37] and voltammetric method by using graphite pencil electrode [38] . The main problems encountered in using some methods are time-consuming extraction and separation procedures.…”

Different Mathematical Spectrophotometric Methods for Determination of Ampyrone in Presence of Its Acid Degradation Product

“…It used as a colorimetric detection for determination Cu 2+ in aqueous solution [6], Fe +2 in water [7] and determination of phenolic drugs via oxidative coupling reaction forming coloured products [8,9]. There are many methods for the determination of Ampyrone including solid-phase spectrophotometry [10], electrochemical method based on fabrication of multi-walled carbon nanotube electrodes for the estimation toxic drugs Ampyrone [11], electrochemical method by using graphite pencil electrode [12], LC/Mass spectrometry [13] and capillary electrophoresis [14]. This work presented three spectrophotometric methods for the determination of the minor component Ampyrone with a presence of its acidic product based on zero order spectra, such as: area under curve method, simultaneous equation method and its modified version.…”