Electrochemical behavior of an antiviral drug acyclovir at fullerene-C60-modified glassy carbon electrode

Shetti, Nagaraj P.; Malode, Shweta J.; Nandibewoor, Sharanappa T.

doi:10.1016/j.bioelechem.2012.06.004

Cited by 131 publications

(41 citation statements)

References 43 publications

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“…This anodic peak is related to the oxidation of the guanine group of GCV to 8-oxo-guanine compound according to the following mechanism (Scheme 1). The same pathway for the oxidation of GCV has been reported by other researchers [10,31].…”

Section: Electrochemical Behavior Of Gcvsupporting

confidence: 73%

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

2016

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Section: Electrochemical Behavior Of Gcvsupporting

confidence: 73%

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

2016

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“…Also, potential shifted positively with increasing scan rate implies the irreversibility of behavior analyte at the modified electrode. And also putting of transfer coefficient anodic equal to 0.5, the number of electrons involved during oxidation of ACV was found to be as 2.03 ( % 2), That's the amount with the results in other reported works, is in good agreement [15,17]. The data obtained represents this is the reaction process was controlled by absorption.…”

Section: Effect Of Scan Ratesupporting

confidence: 80%

“…To overcome these difficulties, chemically modified electrodes (CME) have been employed by researchers. Another study revealed that a fullerene-C 60 -modified glassy carbon electrode can remarkably enhance electrocatalytic activity towards the oxidation of ACV [15]. L À1 was obtained.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Double‐step Modified Carbon Paste Electrode for Trace Quantification of Acyclovir Using TiO₂ Nanoparticle and β‐Cyclodextrin

2018

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In this work we reported, a simple and reproducible double‐step modified carbon paste electrode (CPE) for recognition and designation of Acyclovir (ACV). In the first stage, for acquiring the structure of TiO2 NPs‐CPE, 5 % TiO2 nanoparticles (NPs) doped into the electrode tissue. In the second stage, β‐Cyclodextrin (β‐CD) anchored on the TiO2 NPs‐CPE surface by electropolymerization which yields a β‐CD/TiO2 NPs‐CPE. Topography, characteristics and electrochemical response of the fabricated electrodes with such techniques as: the field emission scanning electron microscopy (FESEM), chronocoulometry (CC), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were analyzed. Also the spent TiO2 NPs powders were characterized by X‐ray diffraction (XRD). The results illustrated that this sensor designed efficiently increases the surface area of composite electrode and the performance of the oxidation of ACV at the surface modified electrode compared to the bare electrode improved. Under the desirable situations, the proposed of analytical procedure was proved to be applicable in two linear calibration ranges betwixt 0.09 to 2.98 and 2.98 to 47.61 μM. The detection limit was estimated for low concentrations ACV 21 nM (S/N=3). Eventually, the fabricated composite electrode was successfully applied for the detection of trace amounts of the ACV in the blood serum samples.

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“…3 6 as a probe at different scan rates [27]. For a reversible process, the Randles -Sevcik formula has been used [28][29][30][31]. …”

Section: Effect Of Scan Ratementioning

confidence: 99%

“…Since, phosphate buffer gave a good peak response (peak shape and peak current), it was selected for further studies. For this, we prepared phosphate buffers of different pH (2.68, 4.2, 4.43, 5.43, 6.5, 7.4, 8.07, 9.27, and 10.4) [28]. The phosphate buffer solution of pH 2.68 (Fig.…”

Section: Voltammetric Behavior Of Ptdmentioning

confidence: 99%

Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

Shetti

2017

Asian J Pharm Clin Res

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Objective: This study was undertaken to propose electro-oxidation mechanism and to develop a selective and sensitive method for the determination of an anti-cancer drug, pemetrexed disodium (PTD). Methods:The electrochemical oxidation of anti-cancer drug PTD has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentration, scan rate, and excipients were investigated to optimize the experimental conditions.Results: According to the liner relation between peak potential, peak current, scan rate and PTD concentration, differential pulse voltammetric method for the quantitative determination in phosphate buffer solution was developed. The linear response was obtained in the range of 10 μM to 0.75 μM with a detection limit of 0.19 μM. The electrochemical oxidation of mechanism of anti-cancer drug PTD was proposed. Conclusion:The proposed method is rapid and does not include any time-consuming steps. The simplicity, sensitivity, and low cost of analysis are the main features of the proposed method for the determination of PTD.

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Electrochemical behavior of an antiviral drug acyclovir at fullerene-C60-modified glassy carbon electrode

Cited by 131 publications

References 43 publications

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Preparation of a Double‐step Modified Carbon Paste Electrode for Trace Quantification of Acyclovir Using TiO₂ Nanoparticle and β‐Cyclodextrin

Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

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Electrochemical behavior of an antiviral drug acyclovir at fullerene-C60-modified glassy carbon electrode

Cited by 131 publications

References 43 publications

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Preparation of a Double‐step Modified Carbon Paste Electrode for Trace Quantification of Acyclovir Using TiO2 Nanoparticle and β‐Cyclodextrin

Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

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Preparation of a Double‐step Modified Carbon Paste Electrode for Trace Quantification of Acyclovir Using TiO₂ Nanoparticle and β‐Cyclodextrin