Electrochemical Detection of Dopamine and Serotonin in the Presence of Interferences in a Rotating Droplet System

Kundys, Magdalena; Bączyńska, Ewa; Jönsson-Niedziółka, Martin

doi:10.1021/acs.analchem.9b02967

Cited by 37 publications

(24 citation statements)

References 34 publications

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“…As per our best knowledge, ease synthesized one dimensional (1D) (ZnO NRs) 1 www.nature.com/scientificreports/ electrochemical 5-HT sensing studies. The efficient performance of this sensing protocol has been reflected through comparable lower LOD values (0.66 μM), wide range of detection range (7.5-300 μM) with less volume of sample required (40 µL) in comparable to other related investigations 88,89 .…”

Section: Eds Analysismentioning

confidence: 84%

Structural refinement and electrochemical properties of one dimensional (ZnO NRs)1−x(CNs)x functional hybrids for serotonin sensing studies

Mullani

Dhodamani

Shellikeri

et al. 2020

Sci Rep

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Herein, the efficient serotonin (5-HT) sensing studies have been conducted using the (ZnO NRs)1−x(CNs)x nanocomposites (NCs) having appropriate structural and electrochemical properties. Initially, the different compositions of ZnO nanorods (NRs), with varying content of carbon nanostructures (CNs=MWCNTs and RGO), are prepared using simple in-situ wet chemical method and thereafter these NCs have been characterized for physico-chemical properties in correlation to the 5-HT sensing activity. XRD Rietveld refinement studies reveal the hexagonal Wurtzite ZnO NRs oriented in (101) direction with space group ‘P63mc’ and both orientation as well as phase of ZnO NRs are also retained in the NCs due to the small content of CNs. The interconnectivity between the ZnO NRs with CNs through different functional moieties is also studied using FTIR analysis; while phases of the constituents are confirmed through Raman analysis. FESEM images of the bare/NCs show hexagonal shaped rods with higher aspect ratio (4.87) to that of others. BET analysis and EIS measurements reveal the higher surface area (97.895 m2/g), lower charge transfer resistance (16.2 kΩ) for the ZCNT 0.1 NCs to that of other NCs or bare material. Thereafter, the prepared NCs are deposited on the screen printed carbon electrode (SPCE) using chitosan as cross-linked agent for 5-HT sensing studies; conducted through cyclic voltammetry (CV) and square wave voltammetry (SWV) measurements. Among the various composites, ZCNT0.1 NCs based electrodes exhibit higher sensing activity towards 5-HT in accordance to its higher surface area, lower particle size and lower charge transfer resistance. SWV measurements provide a wide linear response range (7.5–300 μM); lower limit of detection (0.66 μM), excellent limit of quantification (2.19 μM) and good reproducibility to ZCNT 0.1 NCs as compared to others for 5-HT sensing studies.

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Section: Eds Analysismentioning

confidence: 84%

Structural refinement and electrochemical properties of one dimensional (ZnO NRs)1−x(CNs)x functional hybrids for serotonin sensing studies

Mullani

Dhodamani

Shellikeri

et al. 2020

Sci Rep

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“…The prepared Tyr biosensor showed good detection performance towards dopamine compared to previously reported sensors and biosensors (Table 1). [13–32] …”

Section: Electrochemical Detection Of Dopaminementioning

confidence: 99%

“…A detailed discussion of Tyr catalyzed dopamine oxidation reaction has been provided in later sections. Several kinds of functionalized electrochemical sensors [24–30] and biosensors [31,32] were also reported for dopamine screening, however, the detection limits of fabricated electrodes were found to be high (Table 1). [13–32] …”

Section: Introductionmentioning

confidence: 99%

Disposable Capacitive Biosensor for Dopamine Sensing

Dhanjai

Mugo

2020

ChemistrySelect

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The present paper reports fabrication of a disposable tyrosinase (Tyr) biosensor for rapid detection of dopamine. Tyr immobilized polyaniline/carbon nanotubes/cellulose nanocrystals (Tyr@PANI/CNTs/CNC) conductive film was fabricated on polyvinyl acetate (PVA) transparency and characterized by scanning electron microscopy (SEM) and cyclic voltammetry (CV). Tyr catalyzed dopamine oxidation to o‐dopaquinone was analysed by CV and capacitance was recorded. PANI/CNTs/CNC film acted as a suitable enzyme support which also showed its synergistic effect in accelerating the biocatalytic oxidation reaction. Tyr biosensor exhibited excellent reproducibility, and specificity towards dopamine with correlation coefficient (R2) of 0.9508 and limit of detection (LOD) of 1.57 nM within linear concentration range of 7–1000 mM. The study suggested practical utilization of disposable biosensor towards dopamine detection in biological fluids.

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“…Dopamine (3,4-dihydroxyphenylethylamine, DA) is one of the key neurotransmitters in the central nervous system of mammals. DA levels affect the human brain functions in transmitting electrical signals, hormonal, emotional, metabolic, renal and also play an important role in immune and cardiovascular systems [ 1 , 2 ]. The normal DA concentration in human blood is in the range 0.01–1 µM [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

2021

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Dopamine (DA) is an important neurotransmitter which indicates the risk of several neurological diseases. The selective determination with low detection limit is necessary for early diagnosis and prevention of neurological diseases associated with abnormal concentration of DA. The purpose of this study is to fabricate a poly(3-aminobenzylamine)/poly(sodium 4-styrenesulfonate) (PABA/PSS) multilayer thin film for use as an electrochemical DA biosensor. The PABA was firstly synthesized using a chemical oxidation method of 3-aminobenzylamine (ABA) monomer with ammonium persulfate (APS) as an oxidant. For electrochemical biosensor, the PABA/PSS thin film was fabricated on fluorine doped tin oxide (FTO)-coated glass substrate using the layer-by-layer (LBL) self-assembly method. The optimized number of bilayers was achieved using SEM and cyclic voltammetry (CV) results. The electroactivity of the optimized LBL thin film toward detection of DA in neutral solution was studied by CV and amperometry. The PABA/PSS thin film showed good sensitivity for DA sensing with sensitivity of 6.922 nA.cm−2.µM−1 and linear range of 0.1–1.0 µM (R2 = 0.9934), with low detection limit of 0.0628 µM, long-term stability and good reproducibility. In addition, the selectivity of the PABA/PSS thin film for detection of DA under the common interferences (i.e., ascorbic acid, uric acid and glucose) was also presented. The prepared PABA/PSS thin film showed the powerful efficiency for future use as DA biosensor in real sample analysis.

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Electrochemical Detection of Dopamine and Serotonin in the Presence of Interferences in a Rotating Droplet System

Cited by 37 publications

References 34 publications

Structural refinement and electrochemical properties of one dimensional (ZnO NRs)1−x(CNs)x functional hybrids for serotonin sensing studies

Structural refinement and electrochemical properties of one dimensional (ZnO NRs)1−x(CNs)x functional hybrids for serotonin sensing studies

Disposable Capacitive Biosensor for Dopamine Sensing

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

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