Electrochemical genosensors for biomedical applications based on gold nanoparticles

Castañeda, María Teresa Uriarte; Merkoçi, Arben; Pumera, Martin; Alegret, Salvador

doi:10.1016/j.bios.2006.08.031

Cited by 145 publications

(66 citation statements)

References 30 publications

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“…Among various metal nanoparticles, gold (Au) is the most widespread material used in optics, electrochemistry, catalysis, and biochemical sensing because it is stable, less toxic and biocompatible [1][2][3][4]. A lot of techniques have been developed for the synthesis of Au nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Chen

2010

Gold Bull

100

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A facile, completely green, and cheap route for the synthesis of Au nanoparticles at 25-75°C has been developed by using only hydrogen tetrachloroaurate as the precursor and gum arabic (GA) simultaneously as a reducing agent and a stabilizing agent. No extra reagents are needed. From the analyses of UV/VIS absorption spectra, TEM, HRTEM, SAED, and XRD patterns, the formation of Au nanoparticles with a fcc structure was recognized. The synthesis reaction was usually finished in 2-4 h. Increasing the reaction temperature increased the formation rate but had no significant effect on the optical property and size of Au nanoparticles. With increasing Au(III) ion concentration or GA concentration, the mean diameter of Au nanoparticles slightly increased. Also, the particle size distribution became broader at higher Au(III) ion concentration or lower GA concentration due to the insufficient protection. Although raising the GA concentration was helpful to reduce Au(III) ions completely and stabilize the Au nanoparticles, too high GA concentration was not suitable for the stabilization of Au nanoparticles because the increased intermolecular force of GA might hinder the dispersion of Au nanoparticles. Furthermore, the resultant Au nanoparticles were found to remain highly stable in the NaCl solution.

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Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Chen

2010

Gold Bull

100

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“…Other approaches are the use of AuNPs as a core/seed that can be tailored with a wide variety of surface functionalities to provide highly selective nanoprobes for diagnosis (You et al, 2007); the utilization of Surface Plasmon resonance (SPR) scattering imaging or SPR absorption spectroscopy generated from antibody conjugated AuNPs in molecular biosensor techniques for the diagnosis and investigation of oral epithelial living cancer cells in vivo and in vitro (El-Sayed et al, 2005a); the use of multifunctional AuNPs which incorporate both cytosolic delivery and targeting moieties on the same particle functioning as intracellular sensors to monitoring actin rearrangement in live fibroblasts (Kumar et al, 2007); and the employment of AuNPs in electrochemical based methods that can be coupled with metal deposition for signal enhancement (Castaneda et al, 2007).…”

Section: Nanodiagnosticsmentioning

confidence: 99%

Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

Conde

Tian²,

Baptista

et al. 2014

Nano-Oncologicals

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After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely.It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer.It is indisputable that the use of gold nanocarriers has been gaining momentum as vectors for therapy and diagnostic strategies, combining the AuNPs' ease of functionalization with numerous biomolecules, high loading capacity and fast uptake by target cells. In fact, over the last decade nearly 12.000 research papers focusing on multifunctional gold nanocarriers have been published in peer-reviewed journals. Some of the described nanosystems will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their 2 integration in future diagnostics platforms. Nevertheless, very little gave fruitful results in order to improve a bench-to-bedside approach to translational research. On the basis of theoretical and experimental results obtained so far are we or not at the point: from bench to bedside and back again? As you will see, the answers to this question are complex, but one thing is clear: Translation into clinics is a tortuous and difficult path. Here, we provide a critical review about the available multifunctional gold nanocarriers for in vitro application and in vivo cancer targeting on nanodiagnostics and therapy.

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“…The latter typically employs sandwich binding-induced clustering where a molecule of interest is bound to multiple receptors tethered onto MNP surfaces, resulting in the agglutination of MNPs. Accordingly, the addition of a target triggers clustering of MNPs, leading to changes in the size and the number of agglomerated particles with the analyte concentration, which is referred to as a clustering assay (Aurich et al 2006;Baudry et al 2006;Castañeda et al 2007;Göransson et al 2010;Josephson et al 2001;Koh et al 2009;Liang et al 2011;Ling et al 2010;Perez et al 2002;Ranzoni et al 2012;Zhang et al 2013a). Such a volume-based MNP clustering assay is particularly appealing since it allows simple mix-and-read type measurements and reduced reaction time by use of external magnetic fields (Baudry et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Blu-ray based optomagnetic aptasensor for detection of small molecules

Yang

Donolato

Pinto

et al. 2016

Biosensors and Bioelectronics

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Electrochemical genosensors for biomedical applications based on gold nanoparticles

Cited by 145 publications

References 30 publications

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Facile green synthesis of gold nanoparticles with gum arabic as a stabilizing agent and reducing agent

Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

Blu-ray based optomagnetic aptasensor for detection of small molecules

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