Electrochemical Glucose Sensing: Is There Still Room for Improvement?

Nery, Emilia Witkowska; Kundys, Magdalena; Jeleń, Paulina S.; Jönsson-Niedziółka, Martin

doi:10.1021/acs.analchem.6b03151

Cited by 246 publications

(131 citation statements)

References 119 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…However, miniaturization of sensors has several issues, such as small sensing area, structural change of GOD and acceleration of the enzyme deactivation by direct immobilization, which make it difficult to continuously monitor BG fluctuations [10]. Some studies have optimized the efficiency of electron transfer by increasing the number of active sites and the catalytic ability of immobilized enzyme on sensor surface [11][12][13][14]. One of the most promising methods is to modify the surface of bare electrodes by metal nanomaterials with high superficial area, excellent biocompatibility and catalytic properties [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

View full text Add to dashboard Cite

This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes.

show abstract

Section: Introductionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Chronoamperometry was used to measure sequential addition of glucose to PBS pH 7.2 ( ). The unstrained, transferred electrode showed a LOD of 2.68 × 10 −7 m which is adequate for glucose detection in the sweat of hypoglycemic and hyperglycemic patients (2 × 10 −5 –6 × 10 −4 m ) 29. The detection of glucose using prestrained electrodes was evaluated after being stretched up to 210% of its length.…”

Section: Figurementioning

confidence: 99%

Stretchable Sensors for Nanomolar Glucose Detection

Imamura

Zakashansky

Cho

et al. 2020

Adv Materials Technologies

View full text Add to dashboard Cite

surface area. [12,13] To overcome this issue, nanostructured electrodes with small geometric footprints have been fabricated to achieve higher surface area than their planar counterparts. [14][15][16][17] Wearable sensors in particular should be biocompatible and withstand physiological strains due to motion and deformation of human skin, which is ≈30%. [18,19] Stretchable gold electrodes have been evaluated as glucose detection platforms. Chan et al. demonstrated stability at strains up to 230% with their solution-processed wrinkled gold glucose sensor, with a limit of detection (LOD) of 1 × 10 −3 m in artificial sweat. [20] Zhai et al. reported gold nanowire-based electrodes functionalized with glucose oxidase that were stretched to 20% strain to detect glucose concentrations of 1 × 10 −5 m in a solution of NaOH, while Zhao et al. demonstrated a gold-fiber based sensor functionalized with glucose oxidase capable of detecting 6 × 10 −6 m glucose in phosphate-buffered solution (PBS) under strains up to 200%. [21,22] It is critical to have low detection limits and high sensitivity due to lower concentration of glucose in sweat in comparison with other biological fluids. In this work, we introduce a highly stretchable electrode with the lowest limit of detection to the best of our knowledge for flexible enzyme-free glucose sensing at physiological pH.We introduce stretchable wrinkled electrodes for electrochemical sensing by depositing thin gold metal thin film on polyolefin (PO), which shrinks to 5% of its original area. During the shrinking process, the stiffness mismatch between the polymer and the gold thin film leads to buckling of the gold and results in hierarchical, wrinkled structures. The shrinking factor (the ratio of the average unshrunk electrode's geometric area to that of the processed electrode) of the prestressed thermoplastic PO is 21.8. The wrinkled thin film is then transferred to an elastomer. The transfer of the electrode from shape-memory polymer to elastomer results in additional shrinking due to lift-off process, with a total shrinking factor of 33.4 (Figure 1a). The transferred electrodes retain the wrinkled structures (Figure 1b-d) and upon application of strain, the wrinkles stretch and separate from each other as cracks are sustained in the gold thin film (Figure 1e-g).Electrochemical properties of the wrinkled electrodes were characterized by measuring the electrochemical active surface area (EASA) in different solutions. The wrinkled structures contribute to high surface area, which directly correlates Biosensors that detect analytes in sweat face the challenge of maintaining sensitivity upon miniaturization. Various materials and processes have been developed to create nanostructured electrodes with high surface areas to mitigate this issue. The need remains, however, for biocompatible materials that can be scalably integrated into wearable devices. This paper details a gold thin-film electrode fabricated using a thermoplastic shape memory polymer to create hierarchical wrinkled stru...

show abstract

“…in 2010, while better flow control might represent one of the major obstacles for their commercialized applications . So far, μPED system that is the closest to practical application is demonstrated by Acreo Company (Sweden), who presented an entire glucose detection system equipped with battery, microfluidic sensor and electrochromic display unit on a piece of plastic or paper (Figure f) . However, the printed circuits still base on silicon chip and conventional alkaline battery, which inevitably increases cost and may cause environmental pollution.…”

Section: Electrochemical Sensing Devicesmentioning

confidence: 99%

“…[89] So far, μPED system that is the closest to practical application is demonstrated by Acreo Company (Sweden), who presented an entire glucose detection system equipped with battery, microfluidic sensor and electrochromic display unit on a piece of plastic or paper (Figure 7f). [75,[90][91] However, the printed circuits still base on silicon chip and conventional alkaline battery, which inevitably increases cost and may cause environmental pollution. It is envisioned that in the future μPEDs can be fabricated mainly by paper materials, using paper-based power supplies, the development of which will also be presented later.…”

Section: Medical Diagnosismentioning

confidence: 99%

Paper‐Based Microfluidics for Electrochemical Applications

2019

View full text Add to dashboard Cite

Paper‐based microfluidics is characteristic of fluid transportation through spontaneous capillary action of paper and has exhibited great promise for a variety of applications especially for sensing. Furthermore, paper‐based microfluidics enables the design of miniaturized electrochemical devices to be applied in the energy sector, which is especially attractive for the rapid growing market of small size disposable electronics. This review gives a brief summary on the basics of paper chemistry and capillary‐driven microfluidic behavior, and highlights recent advances of paper‐based microfluidics in developing electrochemical sensing devices and miniaturized energy storage/conversion devices. Their structural features, working principles and exemplary applications are comprehensively elaborated and discussed. Additionally, this review also points out the existing challenges and future opportunities of paper‐based microfluidic electronics.

show abstract

Electrochemical Glucose Sensing: Is There Still Room for Improvement?

Cited by 246 publications

References 119 publications

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Stretchable Sensors for Nanomolar Glucose Detection

Paper‐Based Microfluidics for Electrochemical Applications

Contact Info

Product

Resources

About