Electrochemical protein recognition based on macromolecular self-assembly of molecularly imprinted polymer: a new strategy to mimic antibody for label-free biosensing

Zhao, Wei; Li, Bing; Xu, Sheng; Huang, Xuewen; Luo, Jing; Zhu, Ye; Liu, Xiaoya

doi:10.1039/c9tb00220k

Cited by 33 publications

(20 citation statements)

References 46 publications

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“…Any IF value greater than 1 is accepted as the successful outcome of MIP formation. The note about imprinting factor is supported by the findings of the self-assembly of monomers and template molecules [33][34][35]. Such self-assembly involves the ordering of molecules in the pre-polymerization process.…”

Section: The Principals Of Molecular Imprinting Technology Applied For the Formation Of Sensing Platformsmentioning

confidence: 90%

Molecular Imprinting Technology for Determination of Uric Acid

Ratautaitė

Samukaitė-Bubnienė

Plaušinaitis

et al. 2021

IJMS

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The review focuses on the overview of electrochemical sensors based on molecularly imprinted polymers (MIPs) for the determination of uric acid. The importance of robust and precise determination of uric acid is highlighted, a short description of the principles of molecular imprinting technology is presented, and advantages over the others affinity-based analytical methods are discussed. The review is mainly concerned with the electro-analytical methods like cyclic voltammetry, electrochemical impedance spectroscopy, amperometry, etc. Moreover, there are some scattered notes to the other electrochemistry-related analytical methods, which are capable of providing additional information and to solve some challenges that are not achievable using standard electrochemical methods. The significance of these overviewed methods is highlighted. The overview of the research that is employing MIPs imprinted with uric acid is mainly targeted to address these topics: (i) type of polymers, which are used to design uric acid imprint structures; (ii) types of working electrodes and/or other parts of signal transducing systems applied for the registration of analytical signal; (iii) the description of the uric acid extraction procedures applied for the design of final MIP-structure; (iv) advantages and disadvantages of electrochemical methods and other signal transducing methods used for the registration of the analytical signal; (vi) overview of types of interfering molecules, which were analyzed to evaluate the selectivity; (vi) comparison of analytical characteristics such as linear range, limits of detection and quantification, reusability, reproducibility, repeatability, and stability. Some insights in future development of uric acid sensors are discussed in this review.

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Section: The Principals Of Molecular Imprinting Technology Applied For the Formation Of Sensing Platformsmentioning

confidence: 90%

Molecular Imprinting Technology for Determination of Uric Acid

Ratautaitė

Samukaitė-Bubnienė

Plaušinaitis

et al. 2021

IJMS

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Section: Synthesis Methods Of Protein Smipsmentioning

confidence: 99%

“…Different from the above‐mentioned strategy of preparing imprinted films on electrode surfaces by electrodeposition, a novel, effective, and universal electrochemical sensing strategy was proposed by Zhao et al. [ 115 ] During the preparation process, the research group developed a novel macromonomer that can be cross‐linked by ultraviolet (UV) irradiation for the first time, and by inducing the macromonomer to assemble with BSA to form the final imprinted NPs. After 30 min of irradiation, an imprinted film that can specifically recognize BSA was formed on the surface of the gold electrode (Figure 7b).…”

Section: Synthesis Methods Of Protein Smipsmentioning

confidence: 99%

Nanomaterials‐Based Surface Protein Imprinted Polymers: Synthesis and Medical Applications

Pan

Hong

Xie

et al. 2020

Macro Chemistry & Physics

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Proteins are an essential part of organisms and play a very important role in life activities. Molecular imprinting technology (MIT) can prepare functional materials with specific identification abilities. In recent years, various molecularly imprinted materials have been widely used in the fields of solid‐phase extraction, bionic sensing, and on‐line analysis. Due to the limit of the properties of protein macromolecules, the development of MIT for protein molecules is relatively slow. With the continuous deepening on the research of nanomaterials and surface molecular imprinting technology, a large numbers of interesting and successful strategies appear on imprinted protein. Some surface protein imprinting materials with excellent properties and unique functions are applied in proteomics, biological imaging, medical diagnosis, and other fields, showing great potential application value. This paper summarizes the latest preparation and analysis strategies of surface protein imprinting based on nanomaterials, introduces medical application of protein imprinting materials in sample separation and purification, proteomics, biomedical and other aspects in recent years, and looks forward to the development opportunities and challenges in protein imprinting field.

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“…Chemical sensors comprising tailored chemical recognition interface could be a smart choice for label-free detection of a diverse range of analytes. 14,15 In this regard, molecular imprinting 16,17 represents a well-known method for generating synthetic receptor materials offering adequate affinity for target analytes. 18 This technique uses the target analyte as a template structure to generate highly tailored cavities in the polymeric receptors that are the replica of the template and that are capable of selectively binding the target molecules through reversible non-covalent interactions.…”

Section: Several Methods Have Been Developed For the Determination Ofmentioning

confidence: 99%

Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

et al. 2020

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Electrochemical protein recognition based on macromolecular self-assembly of molecularly imprinted polymer: a new strategy to mimic antibody for label-free biosensing

Abstract: A versatile strategy, based on the use of an amphiphilic copolymer as a macromonomer, was developed for the preparation of a fully synthetic MIP sensor for protein recognition

Cited by 33 publications

References 46 publications

Molecular Imprinting Technology for Determination of Uric Acid

Molecular Imprinting Technology for Determination of Uric Acid

Nanomaterials‐Based Surface Protein Imprinted Polymers: Synthesis and Medical Applications

Molecularly imprinted polymeric coatings for sensitive and selective gravimetric detection of artemether

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