Electrochemical sensor based on molecularly imprinted polymer/reduced graphene oxide composite for simultaneous determination of uric acid and tyrosine

Zheng, Weihua; Zhao, Min; Liu, Weilu; Yu, Shangmin; Niu, Liting; Li, Gengen; Li, Haifeng

doi:10.1016/j.jelechem.2018.02.022

Cited by 113 publications

(46 citation statements)

References 35 publications

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“…A DPV sensor displayed a LOD of 1.3 nM and a linear range from 2 µM to 1000 µM in buffer solution at pH 6.8. Molecular imprinted poly (2-amino-5-mercapto-1, 3, 4-thiadiazole) (PAMT) and reduced graphene oxide (MIP/RGO) composite was used for simultaneous determination of UA and tyrosine obtaining a LOD of 3.2 nM for UA by DPV in PBS at pH 5 [149]. This sensor was tested in urine and serum showing recoveries between 94.0% and 106.0%.…”

Section: Uric Acid (Ua)mentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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Electrochemical sensors appear as low-cost, rapid, easy to use, and in situ devices for determination of diverse analytes in a liquid solution. In that context, conducting polymers are much-explored sensor building materials because of their semiconductivity, structural versatility, multiple synthetic pathways, and stability in environmental conditions. In this state-of-the-art review, synthetic processes, morphological characterization, and nanostructure formation are analyzed for relevant literature about electrochemical sensors based on conducting polymers for the determination of molecules that (i) have a fundamental role in the human body function regulation, and (ii) are considered as water emergent pollutants. Special focus is put on the different types of micro- and nanostructures generated for the polymer itself or the combination with different materials in a composite, and how the rough morphology of the conducting polymers based electrochemical sensors affect their limit of detection. Polypyrroles, polyanilines, and polythiophenes appear as the most recurrent conducting polymers for the construction of electrochemical sensors. These conducting polymers are usually built starting from bifunctional precursor monomers resulting in linear and branched polymer structures; however, opportunities for sensitivity enhancement in electrochemical sensors have been recently reported by using conjugated microporous polymers synthesized from multifunctional monomers.

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Section: Uric Acid (Ua)mentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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“…The MIP layer was electropolymerized by using 2‐amino‐5‐mercapto‐1,3,4‐thiadiazole monomer on the electrode modified by rGO and by immobilizing the dual template of uric acid and tyrosine. They explained the sensing mechanism of biosensor by first the recognition of target molecule and thereafter catalyzation of the oxidation reaction on the composite of MIP/rGO by evaluating the electrochemical behavior of tyrosine and uric acid . Under optimal conditions, the resulting nanocomposite exhibited enhanced electron transfer rate, more recognition binding sites, low limit of detection for tyrosine (0.046 µ m ) and uric acid (0.0032 µ m ), and wide linear range.…”

Section: Intrinsically Conductive Polymer Composites For Biosensing Amentioning

confidence: 99%

Progress in the Development of Intrinsically Conducting Polymer Composites as Biosensors

Prajapati

Kandasubramanian

2019

Macro Chemistry & Physics

105

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Biosensors are analytical devices which find extensive applications in fields such as the food industry, defense sector, environmental monitoring, and in clinical diagnosis. Similarly, intrinsically conducting polymers (ICPs) and their composites have lured immense interest in bio‐sensing due to their various attributes like compatibility with biological molecules, efficient electron transfer upon biochemical reactions, loading of bio‐reagent, and immobilization of biomolecules. Further, they are proficient in sensing diverse biological species and compounds like glucose (detection limit ≈0.18 nm), DNA (≈10 pm), cholesterol (≈1 µm), aptamer (≈0.8 pm), and also cancer cells (≈5 pm mL−1) making them a potential candidate for biological sensing functions. ICPs and their composites have been extensively exploited by researchers in the field of biosensors owing to these peculiarities; however, no consolidated literature on the usage of conducting polymer composites for biosensing functions is available. This review extensively elucidates on ICP composites and doped conjugated polymers for biosensing functions of copious biological species. In addition, a brief overview is provided on various forms of biosensors, their sensing mechanisms, and various methods of immobilizing biological species along with the life cycle assessment of biosensors for various biosensing applications, and their cost analysis.

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“…The advantage of conducting polymers is that CP-based layers can be deposited using well controllable [ 22 ] various electrochemical deposition methods. However, mostly potential cycling, which is followed and controlled by CV [ 15 , 23 , 24 ], and potential pulses, which are followed by chronoamperometry [ 16 , 25 , 26 ], are applied. Both the above mentioned methods are providing a great variety of abilities suitable for the most efficient formation and/or modification of formed sensing layers and simultaneous control of formed structure, therefore, the properties of formed CP-based layers can be changed very precisely.…”

Section: Introductionmentioning

confidence: 99%

Molecular Imprinting Technology for Determination of Uric Acid

Ratautaitė

Samukaitė-Bubnienė

Plaušinaitis

et al. 2021

IJMS

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The review focuses on the overview of electrochemical sensors based on molecularly imprinted polymers (MIPs) for the determination of uric acid. The importance of robust and precise determination of uric acid is highlighted, a short description of the principles of molecular imprinting technology is presented, and advantages over the others affinity-based analytical methods are discussed. The review is mainly concerned with the electro-analytical methods like cyclic voltammetry, electrochemical impedance spectroscopy, amperometry, etc. Moreover, there are some scattered notes to the other electrochemistry-related analytical methods, which are capable of providing additional information and to solve some challenges that are not achievable using standard electrochemical methods. The significance of these overviewed methods is highlighted. The overview of the research that is employing MIPs imprinted with uric acid is mainly targeted to address these topics: (i) type of polymers, which are used to design uric acid imprint structures; (ii) types of working electrodes and/or other parts of signal transducing systems applied for the registration of analytical signal; (iii) the description of the uric acid extraction procedures applied for the design of final MIP-structure; (iv) advantages and disadvantages of electrochemical methods and other signal transducing methods used for the registration of the analytical signal; (vi) overview of types of interfering molecules, which were analyzed to evaluate the selectivity; (vi) comparison of analytical characteristics such as linear range, limits of detection and quantification, reusability, reproducibility, repeatability, and stability. Some insights in future development of uric acid sensors are discussed in this review.

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Electrochemical sensor based on molecularly imprinted polymer/reduced graphene oxide composite for simultaneous determination of uric acid and tyrosine

Cited by 113 publications

References 35 publications

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

Progress in the Development of Intrinsically Conducting Polymer Composites as Biosensors

Molecular Imprinting Technology for Determination of Uric Acid

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