Ruxolitinib
(RXL) is a Janus kinase inhibitor used for
treating
intermediate- or high-risk myelofibrosis. This study presents an electrode
modified with electrochemically polymerized taurine on a carbon paste
electrode via cyclic voltammetry (CV). The surface characterization
of the poly(taurine)-CP electrode was evaluated by using electrochemical
(electrochemical impedance spectroscopyEIS, CV), morphological
(scanning electron microscopeSEM), and spectroscopic (Fourier-transform
infrared spectroscopyFT-IR) techniques. Under optimized conditions,
RXL exhibited good linearity within the 0.01–1.0 μM concentration
range, with a limit of detection (LOD) of 0.005 μM. The proposed
electrochemical sensor demonstrated excellent selectivity, accuracy,
precision, and repeatability. Furthermore, it effectively detected
RXL in human urine and pharmaceutical samples.