Electrochemical ultrasensitive detection of CYFRA21-1 using Ti3C2Tx-MXene as enhancer and covalent organic frameworks as labels

Cheng, Jiamin; Hu, Kai; Liu, Qianrui; Liu, Yanju; Yang, Huaixia; Kong, Jinming

doi:10.1007/s00216-021-03212-y

Cited by 38 publications

(10 citation statements)

References 40 publications

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“…The development of NSCLC is strongly associated with environmental factors and genes, such as age, genetics, immune and nutritional status, bad living habits, and environmental pollution. The insidiousness of earlystage symptoms usually results in an undesirable treatment timing [13,14], which necessitates the significance of early diagnosis and treatment for NSCLC patients. Tumor markers are simple and noninvasive in the diagnosis of lung cancer, with great merit in the diagnosis of tumors, disease monitoring, and efficacy assessment [15].…”

Section: Discussionmentioning

confidence: 99%

Application Value of Serum TK1 and PCDGF, CYFRA21-1, NSE, and CEA plus Enhanced CT Scan in the Diagnosis of Nonsmall Cell Lung Cancer and Chemotherapy Monitoring

Wang

2022

Journal of Oncology

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Objective. To assess the application value of serum thymidine kinase 1 (TK1) and PC cell-derived growth factor (PCDGF), cytokeratin 19 fragment 21-1 (CYFRA21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) plus enhanced CT scan in the diagnosis of nonsmall cell lung cancer (NSCLC) and chemotherapy monitoring. Methods. Between April 2019 and April 2021, 30 patients with NSCLC assessed for eligibility treated in our institution were included in the experimental group, and 30 healthy individuals screened out from physical examinations were recruited in the control group. The chemotherapy regimens included gemcitabine plus cisplatin, pemetrexed disodium plus cisplatin, and vinorelbine plus cisplatin. The application value of serum TK1, PCDGF, CYFRA21-1, NSE, CEA, and enhanced CT scan in the diagnosis and chemotherapy monitoring of NSCLC was analyzed. Results. Before treatment, the eligible patients had significantly higher serum levels of TK1, PCDGF, CYFRA21-1, NSE, and CEA than those of the healthy individuals included ( P < 0.05 ). Clinical efficacy was categorized into good and poor, and the good efficacy included complete response and partial response, with the poor efficacy including stable disease and progressive disease. Patients with good clinical efficacy had lower levels of serum TK1, PCDGF, CYFRA21-1, NSE, and CEA than those with poor efficacy ( P < 0.05 ). Joint detection showed a larger area under the curve (AUC) (0.900; 95%CI, 0.812-0.988), a higher sensitivity, and a superior detection outcome to the stand-alone detection ( P < 0.05 ). Diagnostic results were similar between joint detection and pathological examination ( P > 0.05 ). Conclusion. The application of serum TK1, PCDGF, CYFRA21-1, NSE, and CEA assay plus enhanced CT scan shows high sensitivity and diagnostic accuracy in the diagnosis and chemotherapy monitoring of nonsmall cell lung cancer and thus provides a diagnostic reference basis.

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Section: Discussionmentioning

confidence: 99%

Application Value of Serum TK1 and PCDGF, CYFRA21-1, NSE, and CEA plus Enhanced CT Scan in the Diagnosis of Nonsmall Cell Lung Cancer and Chemotherapy Monitoring

Wang

2022

Journal of Oncology

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“…Prompt recognition of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is important therefore, Zhang et al [394] proposed CRISPR-Cas12a activity by utilizing AuNPs/MXene@PAMAM/SPCE cTnT 0.1-1000 ng mL −1 0.069 ng mL −1 -≈ 0.17 V [372] MXene (Ti 3 C 2 )-AuNPs PSA 1-50 000 pg mL −1 0.31 pg mL −1 -≈ 0.17 V [334] PSA/BSA/anti-PSA/AuNPs-M-NTO-PEDOT/ GCE PSA 0.0001-20 ng mL −1 0.05 pg L −1 ≈ 0.225 V [235] GCE/Au-Ti 3 C 2 T x CYFRA21-1 0.5-1.0 × 10 4 pg•mL −1 0.1 pgmL −1 -≈ 0.25 V [373] GCE/Nafion-AuNPs/Ab 1 /BSA/CYFRA21-1/ Ab 2 -TB-AuNPs@MoS 2 @Ti 3 C 2 T x CYFRA21-1 0.5 pg mL −1 -50 ngmL −1 0.03 pg mL −1 10 −4 A V −1 0.25 V [374] BSA/aptamer/He@CCNT/Ti double-stranded DNA that was amplified by 3D DNA walker. It was used for the ECL biosensor to determine SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) gene.…”

Section: Electrochemiluminescence (Ecl) Biosensorsmentioning

confidence: 99%

2D MXene‐Based Biosensing: A Review

Amara

Hussain

Ahmad

et al. 2022

Small

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MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of the ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, and good redox capability have made MXene a potential candidate for biosensing applications. The hydrophilic nature, biocompatibility, antifouling, and anti‐toxicity properties have opened avenues for MXene to perform in vitro and in vivo analysis. In this review, the concept, operating principle, detailed mechanism, and characteristic properties are comprehensively assessed and compiled along with breakthroughs in MXene fabrication and conjugation strategies for the development of unique electrochemical and optical biosensors. Further, the current challenges are summarized and suggested future aspects. This review article is believed to shed some light on the development of MXene for biosensing and will open new opportunities for the future advanced translational application of MXene bioassays.

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“…Similar examples have been reported using COFs labelled with other electroactive molecules, such as toluidine blue (TB). A representative example is the development of an immunosensor for cytokeratin fragment antigen 21-1 (CYFRA21-1), which can be used as an important indicator for predicting non-small cell lung cancer [116]. In this work, the authors synthetized the TpPa-NO 2 -COF by Schiff base condensation reaction between triformylphloroglucinol and 2-nitrobenzene-1,4-diamine, loaded with AuNPs by the in situ reduction of chloroauric acid and loaded with CYFRA21-1 antibodies (Ab2) and TB.…”

Section: Immunosensorsmentioning

confidence: 99%

Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

Martínez‐Periñán

Martínez-Fernández

Segura

et al. 2022

Sensors

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Covalent organic frameworks (COFs) are defined as crystalline organic polymers with programmable topological architectures using properly predesigned building blocks precursors. Since the development of the first COF in 2005, many works are emerging using this kind of material for different applications, such as the development of electrochemical sensors and biosensors. COF shows superb characteristics, such as tuneable pore size and structure, permanent porosity, high surface area, thermal stability, and low density. Apart from these special properties, COF’s electrochemical behaviour can be modulated using electroactive building blocks. Furthermore, the great variety of functional groups that can be inserted in their structures makes them interesting materials to be conjugated with biological recognition elements, such as antibodies, enzymes, DNA probe, aptamer, etc. Moreover, the possibility of linking them with other special nanomaterials opens a wide range of possibilities to develop new electrochemical sensors and biosensors.

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Electrochemical ultrasensitive detection of CYFRA21-1 using Ti3C2Tx-MXene as enhancer and covalent organic frameworks as labels

Cited by 38 publications

References 40 publications

Application Value of Serum TK1 and PCDGF, CYFRA21-1, NSE, and CEA plus Enhanced CT Scan in the Diagnosis of Nonsmall Cell Lung Cancer and Chemotherapy Monitoring

Application Value of Serum TK1 and PCDGF, CYFRA21-1, NSE, and CEA plus Enhanced CT Scan in the Diagnosis of Nonsmall Cell Lung Cancer and Chemotherapy Monitoring

2D MXene‐Based Biosensing: A Review

Electrochemical (Bio)Sensors Based on Covalent Organic Frameworks (COFs)

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