Electrochemically driven reagent release from an electronic suture

Abstract

Sutures loaded with growth factors or antimicrobials are common place but the release of the therapeutic agent is almost invariably achieved through passive release mechanisms. A gold microwire loaded with cellulose acetate phthalate encapsulated drug droplets is proposed as an alternative design approach. The release mechanism relies upon the imposition of a suitable reducing potential at the gold suture resulting in an increase in local pH and thereby induces the dissolution of the polymeric binder and releases the drug. The ability to actively control the dissolution-release processes could lay the foundations for smart suture design where more responsive/metered dosing can be achieved.

Viscoelastically active sutures – A stitch in time?

“…In addition to developments in "passive" sutures, there has been an upsurge of interest in "smart" sutures. Principally, these exploit the use of shape-memory materials to enable self-tightening and self-knotting for deep wound closures, especially in key-hole surgery [1][2][3][4], but there has also been a growing interest in electronic sutures, with monitoring and actuation capabilities for wound management [1,5,6]; i.e. truly smart sutures.…”