Electrochemically initiated release: exploring new modalities for controlled drug release

Catechin or quercetin guests in an intrinsically microporous polyamine (PIM-EA-TB) host: accumulation, reactivity, and release

“…Catechin has a pK a of approximately 8.7 (ref. 25) and will therefore bind via hydrogen bond as shown in eqn (3).…”

“…Binding and release of guest species in microporous environments are important in selective recovery of valuable species from waste or the environment, 1 in analysis/chromatography or in mass spectroscopy, 2 but also for selective binding and release of drugs in medical applications. 3 The effects of hydrogen bonding of a guest to a microporous host play an important role in modifying host–guest interactions and in pH-modulated accumulation and release processes. 4 Here, polyamines of intrinsic microporosity are considered as hosts with rigid nanochannels to allow spontaneous accumulation and release of herbal drugs with high efficiency.…”

Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

“…Establishing the physicochemical profile of compounds with potential biological uses is extremely important for both understanding their mode of action and determining the most favorable conditions to achieve maximum pharmaceutical efficacy [59]. Knowledge of the redox properties of pharmaceuticals is also of use in studies focusing on developing new methods that allow electrochemically controlled drug release [60]. Moreover, it has been shown that the mechanism of the biological activity of some compounds is influenced by their redox activity [61,62].…”