Electroimmobilization of DNA for ultrafast detection on a microchannel integrated pentacene TFT

Chand, Rohit; Jeun, Jun-Ho; Park, Min‐Ho; Kim, Jungmin; Shin, Ik‐Soo; Kim, Yong−Sang

doi:10.1016/j.jiec.2014.02.039

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…These fluorescence images confirm the specificity and selectivity of our sensor and that the change in pentacene TFT’s performance is the result of DNA immobilization and hybridization. The bright individual spots of DNA rather than patchy fluorescence also prove that the Au floating electrode on active layer aids in better distribution and alignment of DNA …”

Section: Resultsmentioning

confidence: 96%

“…The bright individual spots of DNA rather than patchy fluorescence also prove that the Au floating electrode on active layer aids in better distribution and alignment of DNA. 6 3.4. Detection of Viral DNA.…”

Section: Resultsmentioning

confidence: 99%

“…The source/drain and Au floating electrode (of different width) were patterned to about 100 nm thickness by thermal evaporation using shadow mask defining a pentacene channel of width 1500 μm and length 250 μm. A negatively molded 150 μm wide PDMS microchannel was integrated on the final pentacene TFT, following the steps described in our previous work …”

Section: Methodsmentioning

confidence: 99%

“…A negatively molded 150 μm wide PDMS microchannel was integrated on the final pentacene TFT, following the steps described in our previous work. 6 2.2. Immobilization of DNA on the Au Floating Electrode.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, various research groups have reported a pentacene-based DNA detector. − Pentacene as an active layer is beneficial, as the DNA immobilizes on it without any surface treatment or modification. Although these structures have proven sensitive and effective, it limits the use of pentacene TFT for the detection of DNA only.…”

Section: Introductionmentioning

confidence: 99%

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Mechanism of Label-Free DNA Detection Using the Floating Electrode on Pentacene Thin Film Transistor

et al. 2016

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The analysis of DNA in the posthuman genome project era has become an ever-expanding branch of research and is thus routinely employed in the majority of biochemical laboratories. This work discusses the mechanism and label-free detection of DNA using a pentacene thin film transistor with a gold floating electrode on the active layer. Thiolated polynucleotide probes were used, which form self-aligned monolayers on the floating electrode over the pentacene active layer. The immobilization of the DNA on floating electrode increased the work function and raised the Schottky barrier of the device, resulting in a charge screening effect. Hence, the negative charge of the DNA caused a positive shift in the threshold voltage of the transistor. Based on the change in the electrical output, synthesized DNA and the viral DNA were detected.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanism of Label-Free DNA Detection Using the Floating Electrode on Pentacene Thin Film Transistor

et al. 2016

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Label‐Free DNA Sensors Based on Field‐Effect Transistors with Semiconductor of Carbon Materials

et al. 2015

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Over one decade, various DNA sensors of carbon material-based field-effect transistors (FETs) have been intensively developed into an inspiring area of research and technology to substitute for the traditional method, for instance, fluorescence labeling detection. These FET DNA sensors have advantages of: directly read-out electrical signal, no need to label DNA molecule with fluorescer, high sensitivity, facility of miniaturization, simple device preparation process, high signal-to-noise ratio (SNR) and wide detection range. This review gives a comprehensive description on the state-of-the-art carbon-based FET DNA sensors from the aspect of both semiconductor material and structure of device. Several essential points in this research field, including sensitivity, selectivity, stability and challenges are addressed. Optimization of sensing performance and application of these devices are also discussed.

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Formation of droplet and “string of sausages” for water-ionic liquid ([BMIM][PF6]) two-phase flow in a flow-focusing device

Liu

Zhang

Zhu

et al. 2018

Chemical Engineering and Processing - Process Intensification

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Electroimmobilization of DNA for ultrafast detection on a microchannel integrated pentacene TFT

Cited by 6 publications

References 10 publications

Mechanism of Label-Free DNA Detection Using the Floating Electrode on Pentacene Thin Film Transistor

Mechanism of Label-Free DNA Detection Using the Floating Electrode on Pentacene Thin Film Transistor

Label‐Free DNA Sensors Based on Field‐Effect Transistors with Semiconductor of Carbon Materials

Formation of droplet and “string of sausages” for water-ionic liquid ([BMIM][PF6]) two-phase flow in a flow-focusing device

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