The main plant integration system can improve the power system master station and power plant data interaction, and the quality of its signal link determines the quality of the system. The current link debugging methods mainly filter the signals and ignore the changes of link parameters in different working states, resulting in large link loss and poor signal transmission effect. To enhance the link debugging effect, a signal link closed-loop debugging method based on FPGA is studied. After selecting the FPGA chip, the signal link is reconstructed by FPGA. When a check matrix is established in the form of LDPC code coding for a closed-loop compile link. The neural network is introduced to design the closed-loop debugging model to realize the closed-loop debugging of signal links. Through the experiment of the method, the link SNR is reduced by 23.98% after the debugging method based on FPGA is applied, and the link loss is effectively reduced.