The high-temperature canned electric-actuated valve permanent magnet synchronous motor (CEAV-PMSM) directly drives the valve load, which is prone to eccentricity operation, causing greater system vibration and shortening the valve operating life. In order to analyze the electromagnetic and structural characteristics of CEAV-PMSM under different eccentricity faults, this paper uses analytical methods to derive the magnetic field distribution of the motor under normal and eccentricity conditions. Then, the Maxwell Stress Tensor method is used to derive the expression of the radial electromagnetic force under normal and eccentricity conditions, and the order of space-time harmonics that have a greater impact on CEAV-PMSM are summarized. After that, the electromagnetic performance comparison of the three pole-slot combinations under different eccentricity conditions, and the harmonic orders during eccentricity is analyzed by Fourier transform to obtain the optimal pole-slot combination, which verified the correctness of the analytical calculations. In addition, the influence of different eccentricity conditions on the radial force density and unbalanced magnetic pull are studied. On this basis, the vibration response of the motor under eccentricity is analyzed, and the influence of the canned sleeve on the vibration performance of the motor is discussed. Finally, the modal analysis of CEAV-PMSM is carried out to prevent the occurrence of resonance under eccentricity, which provides some references for reducing the vibration and noise of the canned electric-actuated valve.