Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Li, Jingchao; Luo, Yu; Pu, Kanyi

doi:10.1002/anie.202008386

Cited by 176 publications

(94 citation statements)

References 166 publications

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“…It has been regarded as a highly promising next-generation anticancer strategy, particularly owing to its high efficiency in tumor eradication and prominent ability in long-term tumor suppression through its immunomemory. [65] Whereas, single immunotherapy may suffer from ineffectiveness of treating solid primary tumors [64,66] and potential immune-related adverse events. [67] This calls for partner therapeutic modality (e.g., chemotherapy, or targeted therapy) to augment its anticancer efficacy.…”

Section: Immunotherapy-promoted Mild-temperature Pttmentioning

confidence: 99%

Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Gao

Sun

Liang

2021

Adv Funct Materials

216

121

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Photothermal therapy (PTT), which utilizes near-infrared light-absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mildtemperature PTT, which circumvents the limitations of conventional PTT (e.g., thermoresistance and adverse effects), is emerging and shows great potential in the forthcoming clinical applications. However, mild-temperature PTT without adjuvant therapy is not able to completely eradicate tumors because its therapeutic efficacy is dramatically impaired by its inferior heat intensity. As a result, strategies capable of enhancing the anticancer efficacy of mild-temperature PTT are urgently necessitated, which mainly rely on on-demand fabrication of functionalized nanoagents. In this review, the strategies of nanoagent-promoted mild-temperature PTT are highlighted. Furthermore, challenges and opportunities in this field are rationally proposed, and hopefully people can be encouraged by this promising anticancer therapy.

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Section: Immunotherapy-promoted Mild-temperature Pttmentioning

confidence: 99%

Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Gao

Sun

Liang

2021

Adv Funct Materials

216

121

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“…The strategy of magnetically electronic catalysis is expected to extend the application of alternating magnetic fields in research areas including but not limited to tumor therapy. [11]…”

Section: Introductionmentioning

confidence: 99%

Magneto‐Electrically Enhanced Intracellular Catalysis of FePt‐FeC Heterostructures for Chemodynamic Therapy

Zhang

Yang

et al. 2021

Advanced Materials

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of diseases. For example, inducing cancer cells from the aggressive and unrestricted growth state to a senescent state can limit their proliferation and reduce their resistance to treatments, [2] which can be realized by intracellular catalytic reduction of β-nicotinamide adenine dinucleotide (NAD + ). [3] However, it remains a challenge to realize highly efficient intracellular catalysis of nanocatalysts in the complex tumor microenvironment.Catalytic reaction is accompanied by electron transfer, and regulating the electronic structure of the catalyst has been an efficient way to improve the catalytic activity. [4] Heterostructures are superior in electron regulation owing to the spontaneous charge rearrangement at the interface driven by the difference in work function and Fermi level between materials, [5] thereby influencing the catalytic activities. [6] Moreover, the electron transfer tendency in heterostructures can be managed by integrating materials with different work functions. [7] By integrating Au nanoparticles with higher work function (work function = 5.27 eV) and Fe 2 C nanoparticles (work function = 4.89 eV) into a Janus-like Au-Fe 2 C heterostructure, we recently demonstrated a catalytic radiotherapy owing to enriched charges of Au. [8] However, its efficiency is insufficient. The key to further increasing the catalytic activity lies Intracellular catalytic reactions can tailor tumor cell plasticity toward highefficiency treatments, but the application is hindered by the low efficiency of intracellular catalysis.Here, a magneto-electronic approach is developed for efficient intracellular catalysis by inducing eddy currents of FePt-FeC heterostructures in mild alternating magnetic fields (frequency of f = 96 kHz and amplitude of B ≤ 70 mT). Finite element simulation shows a high density of induced charges gathering at the interface of FePt-FeC heterostructure in the alternating magnetic field. As a result, the concentration of an essential coenzyme-β-nicotinamide adenine dinucleotide-in cancer cells is significantly reduced by the enhanced catalytic hydrogenation reaction of FePt-FeC heterostructures under alternating magnetic stimulation, leading to over 80% of senescent cancer cells-a vulnerable phenotype that facilitates further treatment. It is further demonstrated that senescent cancer cells can be efficiently killed by the chemodynamic therapy based on the enhanced Fentonlike reaction. By promoting intracellular catalytic reactions in tumors, this approach may enable precise catalytic tumor treatment.

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“…[1][2][3][4] The communication between immune cells and tumor/normal cells decides the therapeutic response and tolerance of the immunotherapy. [5][6][7][8][9][10][11][12] The high expression of tumor-recognition antibodies on genetically programmed immune cells endow them better cancer recognition capacity and certain improved therapeutic effects. However, the complicated gene engineering results in a high cost for cell immunotherapy.…”

Section: Introductionmentioning

confidence: 99%