A 1 + 1 dimensional computer simulation model based on aggregation of hard disks is used to investigate the relationship between the nanostructure of simulated thin metallic (e.g., Ni) films on the (111) face of fcc or the (100) face of hcp substrates under different deposition conditions and the stress developed in these films. The intrinsic mechanical stress in these films, while remaining almost constant up to a certain substrate temperature, passes a tensile stress maximum, which depends on the deposition rate, and decreases towards zero with increasing substrate temperature, owing to an increased diffusion process. By increasing the deposition angle, the microstructure of film changes from a dense film with few voids, to a microstructure with (somewhat densely packed) columns/bundles inclined towards the incidence atoms with elongated voids. The latter decreases the tensile stress, while the former increases the compressive stress, resulting in total compressive stress, particularly at deposition angles above 60°. The results are compared with the experiments performed on Ni/glass films that were produced under UHV condition and with different deposition parameters. The nanostrain in the latter films were obtained using the Warren -Averbach method for X-ray diffraction line-broadening analysis. A qualitatively good agreement between simulation and experimental results is obtained.