Electron microscopic study of peripheral giant-cell reparative granuloma

Bartel, H; Piatowska, D

doi:10.1016/0030-4220(77)90354-1

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…1971;Sapp. 1972;Andersen rt rrl, 1973a;Bartel and Piatowska, 1977). The most prominent type of giant cell observed seems to represent a metabolically active cell and the other type, a dying cell (Sapp, 1972;Andersen et 01, 1973a).…”

Section: Discussionmentioning

confidence: 96%

“…Although the origin of the cells present in giant cell granulomas has been investigated through ultrastrutural (Adkins et al, 1969;Sapp, 1972;Andersen et nl, 1973a;Bartel and Piatowska, 1977;El-Labban and Lee, 1983), and immunohistochemical methods (El-Mofty and Osdoby, 1985;Eschenroeder et nl, 1986;Regezi et al, 1987;Farronato et al, 1988;Flanagan et al, 1988;Doussis et al, 1992) there are still some doubts as to the pathogenesis and nature of these lesions.…”

Section: Discussionmentioning

confidence: 99%

“…1969). osteoprogenitor cells (Sapp, 1972), pericytes (Andersen er al, 1973a), fibroblasts (Bartel and Piatowska, 1977) or myofibroblasts (El-Labban and Lee, 1983).…”

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confidence: 99%

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Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study

Carvalho¹,

Gomez

et al. 1995

Oral Diseases

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OBJECTIVE: To study the nature of multinucleated and mononuclear cells from peripheral giant cell granuloma (PGCG). MATERIALS AND METHODS: Formalin‐fixed, paraffin‐embedded sections of 40 cases of PGCG were immunohistochemically stained for vimentin, alpha I‐antichymotrypsin, CD68, S‐100 protein, lysozyme. leucocyte common antigen (LCA), factor VIII‐retated antigen and muscle cell actin. Six cases of PGCG were also studied by transmission etectron microscopy. RESULTS: Vimentin, alpha I‐antichymotrypsin and CD68 were expressed in both the mononuclear and multinucleated giant cells. Dendritic mononuclear cells, positive for 5–100 protein, were noted in 67.5% of the lesions, whereas lysozyme and leucocyte common antigen were detected in occasional mononuclear cells. Ultrastructural examination showed mononuclear cells with signs of phagocytosis and sometimes interdigitations with similar cells. Others presented non‐specific characteristics and the third type exhibited cytoplasmic processes and occasional Birbeck granules. Some multi‐nucleated giant cells showed oval nuclei, abundant mitochondria and granular endoplasmic reticulum whereas others presented with irregular nuclei and a great number of cytoplasmic vacuoles. CONCLUSIONS: lmmunohistochemical and ultrastructural results suggest that PGCGs of the jaws are composed mainly of cells of the mononuclear phagocyte system and that Langerhans cells are present in two thirds of the lesions.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study

Carvalho¹,

Gomez

et al. 1995

Oral Diseases

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“…There is controversy regarding the formation of the MGCs in the GCG. Adkins suggested that the giant cells are formed by the fusion of the stromal cells (19), while others support the fact that they originate from endothelial cells of capillaries (20), fibroblasts (21), or myofibroblasts (22). In our study, both the MGCs and a fraction of round mononuclear stromal cells expressed CD68, a valuable marker of the monocyte/macrophage lineage, from which the progenitor cells of genuine osteoclasts are derived.…”

Section: Discussionmentioning

confidence: 99%

Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts

Liu

2003

J Oral Pathology Medicine

182

150

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These results suggest that MGCs in the four types of giant cell-containing lesions of the jaws show characteristics of the osteoclast phenotype. The mononuclear stromal cells, which show TRAP positively, may be the precursors of the MGCs. RANKL, OPG, and RANK expressed in these lesions may play important roles in the formation of the MGCs. The similar characteristics and mechanisms in the differentiation of MGCs in these lesions also suggest that there might be a similar kind of pathogenesis involved in the formation of the MGCs in these lesions

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“…[ 11 ] Some investigators believe that MNGC have phagocyte, foreign body or osteoclast origin, but in some studies, an endothelial cell origin is suggested. [ 12 13 14 15 ] Moreover, some investigations show that the mononuclear cells of stroma have an important role in the development of the giant cells[ 16 17 ] and few others suggested that MNGC were formed by fusion and adhesion of stromal mononuclear cells, but the related mechanism remains unknown. [ 18 ] Therefore, recent studies of giant cell granulomas have been shifted to mononuclear cells and many investigators believe that mononuclear cells that are a proliferative compartment of these lesions are responsible for their biological activity.…”

Section: Introductionmentioning

confidence: 99%

Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma: An immunohistochemical analysis

Hallikeri

Girish

et al. 2014

J Oral Maxillofac Pathol

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Background:Central and Peripheral giant cell granulomas of jaws are uncommon, benign, reactive disorders that are characterized by the presence of numerous multinucleated giant cells and mononuclear cells within a stroma. The origin of the multinucleated giant cells is controversial; probably originating from fusion of histiocytes, endothelial cells and fibroblasts.Objective:To assess the expression of CD34 and CD68 in central and peripheral giant cell granulomas to understand the origin of these multinucleated giant cells.Materials and Methods:Twenty cases of Central and Peripheral giant cell granulomas were evaluated immunohistochemically for CD34 and CD68 proteins expression.Results:Immunopositivity for CD34 was seen only in cytoplasm of endothelial cells of blood vessels; whereas, consistent cytoplasmic immunopositivity for CD68 was seen in few stromal cells. Statistical significance was seen in mean number of multinucleated giant cells, mean number of nuclei in multinucleated giant cells, CD68 expression and ratio of macrophages to multinucleated giant cells among two lesions.Conclusion:Although the central giant cell granulomas share some clinical and histopathological similarities with peripheral giant cell granulomas, differences in mean number of nuclei in multinucleated giant cells and CD68 immunoreactivity may underlie the distinct clinical behavior.

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Electron microscopic study of peripheral giant-cell reparative granuloma

Cited by 15 publications

References 11 publications

Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study

Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study

Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts

Expression of CD34 and CD68 in peripheral giant cell granuloma and central giant cell granuloma: An immunohistochemical analysis

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