Electron track analysis for damage formation in bio-cells

Abstract

The track structure of electrons generated in bio-tissues exposed to X-rays (or other radiation particles) is essential to cell damage. This paper reports on Monte Carlo track simulations of electrons to determine the degree of concentration of ionization and excitation events as the aggregation index (AI). AI is expected to correlate with the number of lesions in a cell nucleus, such as double-strand breaks (DSBs), which may lead to lethality of cells. The simulation results show that AI as a function of electron energy has a peak in low energy (sub-keV) regions and the induction of the lesions may be attributed to the ionization and excitation clusters generated in the tissues. The track pattern, associated with the primary track and secondary branch tracks, is also illustrated by counting the number of the branching points given by the ionization.

Track Structure Study for Energy Dependency of Electrons and X-rays on DNA Double-Strand Break Induction

“…In terms of physical characteristics, the concentration of energy deposition along electron tracks generated by incident photons is relatively high at the end of the track 13,23 . Irradiation by high energy X-rays on biological tissue generates high energy secondary electrons which conduce to lower the y D value (Fig.…”

Low energy electron generator design and depth dose prediction for micro-superficies tumors treatment purposes

“…Yoshii et al [13] and Tung et al [14] simulated the track of low energy electrons in water but without consideration of the method used for generation or gun apparatus. Tung et al specified the energy deposition in terms of nanometric volume but this study considered micrometric dimensions because tests involved varying and more intense energy levels.…”