Electrooxidation of Iodide in the Presence of 4-Hydroxycoumarin: Application to a Simple Coulometric Titration of 4-Hydroxycoumarin

Nematollahi, Davood; Hamzehloei, Ali; Hesari, Mehdi

doi:10.2116/analsci.19.937

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Some electroanalytical methods have also been used for WA determination in pharmaceutical samples, which can offer some advantages as a simple sample preparation, ease of miniaturization, high sensitivity and their comparative low‐cost. The electroanalysis of WA has been reported by square wave , cyclic voltammetry , differential pulse voltammetry , potentiometry , amperometry , HPLC with electrochemical detection , polarography and coulometric titration . In spite of success of these methods for WA determination, the simplicity and sampling rate required to the routine pharmaceutical analysis is poor.…”

Section: Introductionsupporting

confidence: 67%

Simple and Fast Determination of Warfarin in Pharmaceutical Samples Using Boron‐doped Diamond Electrode in BIA and FIA Systems with Multiple Pulse Amperometric Detection

et al. 2017

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This paper proposes the use of the boron‐doped diamond electrode (BDDE) in flow and batch injection analysis (FIA and BIA) systems with multiple‐pulse amperometric (MPA) detection for the determination of warfarin (WA) in pharmaceutical formulations. The electrochemical behavior of WA obtained by cyclic voltammetry (CV) in 0.1 mol L−1 phosphate buffer shows an irreversible oxidation process at +1.0 V (vs Ag/AgCl). The MPA was based on the application of two sequential potential pulses as a function of time on BDDE: (1) for WA detection at +1.2 V/100 ms and; (2) for electrode surface cleaning at −0.2 V/200 ms. Both hydrodynamic systems (FIA‐MPA and BIA‐MPA) used for WA determination achieved high precision (with relative standard deviations around 2 %, n=10), wide linear range (2.0−400.0 μmol L−1), low limits of detection (0.5 μmol L−1) and good analytical frequency (94 h−1 for FIA and 130 h−1 for BIA). The WA determination made by the proposed methods was compared to the official spectrophotometric method. The FIA‐MPA and BIA‐MPA methods are simple and fast, being an attractive option for WA routine analysis in pharmaceutical industries.

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Section: Introductionsupporting

confidence: 67%

Simple and Fast Determination of Warfarin in Pharmaceutical Samples Using Boron‐doped Diamond Electrode in BIA and FIA Systems with Multiple Pulse Amperometric Detection

et al. 2017

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“…The reaction of 4-hydroxycoumarin and I 2 to form 4-hydroxy-3-iodo-2Hchromen-2-one was shown as the Eq. 6 48 :…”

Section: Resultsmentioning

confidence: 99%

“…High potential would promote the side reaction of 1a and I 2 to form 4-hydroxy-3-iodo-2H-chromen-2-one. 48 While the reaction potential was dropped to 0.2 V, the yield of 3aa was only 28% (entry 5). So, 0.4 V was suitable in the following experiments.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Sulfenylation of 4-Hydroxycoumarins with Aryl Thiols Catalyzed by Potassium Iodide

Jin

Zhao

Zhang

et al. 2021

J. Electrochem. Soc.

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A KI-catalyzed indirect electrochemical oxidative method for the synthesis of sulfenylated 4-hydroxycoumarins via cross-coupling of 4-hydroxycoumarins and aryl thiols at a low potential has been reported. The electrocatalytic activity of KI for sulfenylation of 4-hydroxycoumarin was investigated by cyclic voltammetry. In situ FTIR data reflected the structural change of functional groups during the reaction process. The mechanism of electrochemical sulfenylation involved the generation of intermediate 1,2-bis(4-chlorophenyl)disulfane has been revealed by control experiments. Various sulfenylated 4-hydroxycoumarins were obtained under the optimum reaction conditions in moderate to excellent yields with good functional group tolerance.

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Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

Guedes

Santos

2018

Electroanalysis

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The use of multiple‐pulse amperometry (MPA) for the determination of narrow therapeutic index (NTI) drugs using batch injection analysis (BIA) with carbon screen‐printed electrodes (SPE) is proposed, seeking to develop a practical and low‐cost analysis kit for application in routine quality control of these drugs. The electrochemical behaviors of aminophylline, carbamazepine, clindamycin, colchicine, minoxidil, prazosin, procainamide, theophylline, warfarin and verapamil were evaluated in different electrolytes, but just one, the 0.1 mol L−1 phosphate buffer, pH 7.0, was chosen for determination of all the analytes. The amperometric detection was optimized as a function of the best oxidation potential for carbon SPE for each analyte, which was in a range from 0.7 to 1.1 V. The injection conditions were determined as a function of the velocity and the volume injected by the BIA system, which were 92.5 μL s−1 and 100 μL, respectively. Under these conditions, a good repeatability (RSD<3 %), high analytical frequency (>215 determinations per hour), large linear ranges and low LOD (<0.42 μmol L−1) for all the NTI drugs were obtained. Furthermore, the proposed method provided an easy qualitative analysis of the investigated analytes using MPA detection. The addition‐recovery studies in pharmaceutical samples containing NTI drugs and the comparison with official methods showed that the proposed analysis Kit is a very fast, simple and efficient alternative for quantification of these analytes.

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Electrooxidation of Iodide in the Presence of 4-Hydroxycoumarin: Application to a Simple Coulometric Titration of 4-Hydroxycoumarin

Cited by 4 publications

References 27 publications

Simple and Fast Determination of Warfarin in Pharmaceutical Samples Using Boron‐doped Diamond Electrode in BIA and FIA Systems with Multiple Pulse Amperometric Detection

Simple and Fast Determination of Warfarin in Pharmaceutical Samples Using Boron‐doped Diamond Electrode in BIA and FIA Systems with Multiple Pulse Amperometric Detection

Electrochemical Sulfenylation of 4-Hydroxycoumarins with Aryl Thiols Catalyzed by Potassium Iodide

Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

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