Electrophoretic Analysis of Biomarkers using Capillary Modification with Gold Nanoparticles Embedded in a Polycation and Boron Doped Diamond Electrode

Zhou, Lin; Glennon, Jeremy D.; Luong, John H. T.

doi:10.1021/ac101105q

Cited by 20 publications

(7 citation statements)

References 41 publications

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“…The CE with AD system was described in our previous article . The capillary outlet was epoxy sealed into a pipette tip so that only ∼1 cm protruded.…”

Section: Methodsmentioning

confidence: 99%

CE with a boron‐doped diamond electrode for trace detection of endocrine disruptors in water samples

2013

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Off-line SPE and CE coupled with electrochemical detection have been used for the determination of bisphenol A (BPA), bisphenol F, 4-ethylphenol, and bisphenol A diglycidyl ether in bottled drinking water. The use of boron-doped diamond electrode as an electrochemical detector in amperometric mode that provides a favorable analytical performance for detecting these endocrine-disrupting compounds, such as lower noise levels, higher peak resolution with enhanced sensitivity, and improved resistance against electrode passivation. The oxidative electrochemical detection of the endocrine-disrupting compounds was accomplished by boron-doped diamond electrode poised at +1.4 V versus Ag/AgCl without electrode pretreatment. An off-line SPE procedure (Bond Elut® C18 SPE cartridge) was utilized to extract and preconcentrate the compounds prior to separation and detection. The minimum concentration detectable for all four compounds ranged from 0.01 to 0.06 μM, having S/N equal to three. After exposing the plastic bottle water container under sunlight for 7 days, the estimated concentration of BPA in the bottled drinking water was estimated to be 0.03 μM. This proposed approach has great potential for rapid and effective determination of BPA content present in water packaging of plastic bottles that have been exposed to sunlight for an extended period of time.

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“…The CE with AD system was described in our previous article . The capillary outlet was epoxy sealed into a pipette tip so that only ∼1 cm protruded.…”

Section: Methodsmentioning

confidence: 99%

CE with a boron‐doped diamond electrode for trace detection of endocrine disruptors in water samples

2013

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“…The FASS technique using a fused silica capillary coated with gold nanoparticles (AuNPs) embedded in poly(diallyldimethylammonium) chloride (PDDA) with a boron-doped diamond electrode was investigated for the electrophoretic separation of HVA and VMA by Zhou et al [105]. The authors used the elaborated method for the evaluation of the HVA/VMA ratio in urine samples and for the diagnosis of Menkes disease.…”

Section: Analytical Strategies Of Ba Determinations Based On Separmentioning

confidence: 99%

Recent Trends in the Quantification of Biogenic Amines in Biofluids as Biomarkers of Various Disorders: A Review

Plenis

Olędzka

Kowalski

et al. 2019

JCM

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Biogenic amines (BAs) are bioactive endogenous compounds which play a significant physiological role in many cell processes like cell proliferation and differentiation, signal transduction and membrane stability. Likewise, they are important in the regulation of body temperature, the increase/decrease of blood pressure or intake of nutrition, as well as in the synthesis of nucleic acids and proteins, hormones and alkaloids. Additionally, it was confirmed that these compounds can be considered as useful biomarkers for the diagnosis, therapy and prognosis of several neuroendocrine and cardiovascular disorders, including neuroendocrine tumours (NET), schizophrenia and Parkinson’s Disease. Due to the fact that BAs are chemically unstable, light-sensitive and possess a high tendency for spontaneous oxidation and decomposition at high pH values, their determination is a real challenge. Moreover, their concentrations in biological matrices are extremely low. These issues make the measurement of BA levels in biological matrices problematic and the application of reliable bioanalytical methods for the extraction and determination of these molecules is needed. This article presents an overview of the most recent trends in the quantification of BAs in human samples with a special focus on liquid chromatography (LC), gas chromatography (GC) and capillary electrophoresis (CE) techniques. Thus, new approaches and technical possibilities applied in these methodologies for the assessment of BA profiles in human samples and the priorities for future research are reported and critically discussed. Moreover, the most important applications of LC, GC and CE in pharmacology, psychology, oncology and clinical endocrinology in the area of the analysis of BAs for the diagnosis, follow-up and monitoring of the therapy of various health disorders are presented and critically evaluated.

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“…The electrophoretic separation of indoxyl sulfate, homovanillic acid, and vanillyl mandelic acid, which are important human biomarkers excreted in urine, have been studied using a fused silica capillary coated with gold NPs (AuNPs) embedded in poly(diallyl dimethylammonium) chloride [95]. This approach reverses EOF, allowing fast migration of the analytes while retarding other endogenous compounds, including ascorbic acid, uric acid, catecholamines, and indoleamines, important interferences avoiding offline sample treatment or preconcentration steps.…”

Section: Applications In Cementioning

confidence: 99%

Multidimensional carbon allotropes as electrochemical detectors in capillary and microchip electrophoresis

et al. 2014

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Electrophoretic Analysis of Biomarkers using Capillary Modification with Gold Nanoparticles Embedded in a Polycation and Boron Doped Diamond Electrode

Cited by 20 publications

References 41 publications

CE with a boron‐doped diamond electrode for trace detection of endocrine disruptors in water samples

CE with a boron‐doped diamond electrode for trace detection of endocrine disruptors in water samples

Recent Trends in the Quantification of Biogenic Amines in Biofluids as Biomarkers of Various Disorders: A Review

Multidimensional carbon allotropes as electrochemical detectors in capillary and microchip electrophoresis

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