Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury

Zencirci, Serife Gokce; Bilgin, Mehmet; Yaraneri, H.

doi:10.1016/j.jneumeth.2010.07.008

Cited by 28 publications

(23 citation statements)

References 36 publications

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“…In agreement with our results; studies conducted by Zencirci et al (2010[50]), and Atik et al (2011[2]) reporting that the SFI value was increased significantly in the melatonin-treated groups as compared to the untreated group of rats with peripheral nerve crush injury. Improvement of SFI indicates better motor and sensory function revealing nerve and muscle regeneration as suggested by Sarikcioglu et al (2009[41]).…”

Section: Discussionsupporting

confidence: 93%

“…It is both a lipo- and hydrophilic molecule, and it crosses all physical barriers including the blood-brain barrier and plasma membrane (Zencirci et al, 2010[50]). It is a principal agent which has antioxidant, antiapoptotic, anti-inflammatory (Reiter et al, 2007[34]), and anticarcinogen properties for biological systems (Anisimov et al, 2006[1]).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

Rateb

Amin

Eltablawy

et al. 2017

EXCLI Journal; 16:Doc138; ISSN 1611-2156

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

Rateb

Amin

Eltablawy

et al. 2017

EXCLI Journal; 16:Doc138; ISSN 1611-2156

View full text Add to dashboard Cite

“…Oxidative stress is considered to be one of the main causes of neural damage after injury and thus antioxidant molecules including CAT, SOD, and GST play an important role in peripheral nerve regeneration . The beneficial effects of antioxidant agents such as melatonin, N‐acetylcysteine and edaravone had been demonstrated in sciatic nerve regeneration after nerve crush, sciatic nerve axotomy and ischemia/reperfusion injury respectively . In this study, the mRNA expressions of ZnSOD, CAT, GPx and MT enzymes were elevated within a short time.…”

Section: Discussionmentioning

confidence: 59%

PDLLA/PRGD/β‐TCP conduits build the neurotrophin‐rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration

Qiu

Yin

et al. 2014

J Biomedical Materials Res

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A novel nerve guidance conduit comprising poly{(lactic acid)-co-[(glycolic acid)-alt-(l-lysine)]} (PRGD), poly (d,l-lactic acid) (PDLLA) and β-tricalcium phosphate (β-TCP) was constructed to facilitate the peripheral nerve regeneration. From the comparative study, PDLLA/PRGD/β-TCP conduit achieved the best recovery in regard of the ultrastructure observation and the SFI evaluation. At the first stage of the injury (7 days), the maximum expression augments in ZnSOD (6.4 folds) and GPX4 (6.8 folds) were observed in PDLLA/PRGD/β-TCP group; while striking rise in actin (6.8 folds), tubulin (5.6 folds), and ERM components expressions were observed later (35 days). Meanwhile, compared with PDLLA and PDLLA/PRGD conduits, PDLLA/PRGD/β-TCP conduits achieved the highest local nerve growth factor (NGF) content and an accumulating BDNF content. We speculated that addition of RGD and β-TCP in the composites were the main positive factors to build the microenvironment rich in NGF and BDNF, which help to counteract with the oxidative stress and to boost the cytoskeletal protein expressions. Therefore, PDLLA/PRGD/β-TCP could be promising composites used in peripheral nerve regeneration.

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“…On the other hand, neuroendocrine system might be affected by CR indirectly. In recent years, melatonin, which is secreted by conarium, has been increasingly recognized to improve nerve regeneration and functional reestablishment after nerve injury (54, 55). Additionally, the dose of melatonin must be high enough to achieve a beneficial effect on nerve regeneration.…”

Section: Discussionmentioning

confidence: 99%

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats

Zhu

Liu

et al. 2017

Front. Neurol.

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Circadian rhythm (CR) plays a critical role in the treatment of several diseases. However, the role of CR in the treatment of peripheral nerve defects has not been studied. It is also known that the pulsed electromagnetic fields (PEMF) can provide a beneficial microenvironment to quicken the process of nerve regeneration and to enhance the quality of reconstruction. In this study, we evaluate the impact of CR on the promoting effect of PEMF on peripheral nerve regeneration in rats. We used the self-made “collagen-chitosan” nerve conduits to bridge the 15-mm nerve gaps in Sprague-Dawley rats. Our results show that PEMF stimulation at daytime (DPEMF) has most effective outcome on nerve regeneration and rats with DPEMF treatment achieve quickly functional recovery after 12 weeks. These findings indicate that CR is an important factor that determines the promoting effect of PEMF on peripheral nerve regeneration. PEMF exposure in the daytime enhances the functional recovery of rats. Our study provides a helpful guideline for the effective use of PEMF mediations experimentally and clinically.

show abstract

Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury

Cited by 28 publications

References 36 publications

Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats

PDLLA/PRGD/β‐TCP conduits build the neurotrophin‐rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats

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