Electrophysiological studies of some deep cerebral structures in man

Albé-Fessard, D; Arfel, G; Guiot, G; Derome, P; Hertzog, E; Vourc'h, G; Brown, Hilary F.; Aléonard, P; Herrán, Javier; Trigo, J C

doi:10.1016/0022-510x(66)90038-4

Cited by 77 publications

(48 citation statements)

References 5 publications

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“…Historically, Guiot and Albe-Fessard were the first to identify the Vim nucleus as a target for tremor suppression and to describe the electrophysiological technique for Vim identification [5,6,7,8]. Thalamotomy for the treatment of tremor is one of the oldest procedures in functional surgery [9,10,11,12].…”

Section: Discussionmentioning

confidence: 99%

Prelemniscal Radiations: A New Reliable Landmark of the Thalamic Nucleus Ventralis Intermedius Location?

Lefranc

Carron²,

Régis³

2015

Stereotact Funct Neurosurg

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Background: The thalamic nucleus ventralis intermedius (Vim nucleus) is the main surgical target for the management of intractable tremor. The Vim nucleus cannot be reliably located with routine stereotactic imaging, and so targeting relies on indirect coordinates. Objective: We propose to investigate if colored fractional anisotropy (FA) mapping can help to locate the Vim nucleus by identifying its borders, particularly the prelemniscal radiations (Raprl) that lie below and behind the nucleus. Method: We retrospectively reviewed the colored FA maps for 18 consecutive patients having undergone gamma knife stereotactic Vim thalamotomy for disabling tremor. Results: The Raprl were easily located on colored FA maps and enabled the identification of the lower and posterior borders of the Vim nucleus in all patients. In the medial plane, the mean distance ± SD between the Raprl and Vim nucleus was 0.77 ± 1.19 mm (range: 0.1-3.3). The Raprl were located 1.35 ± 1.33 mm (range: 0.2-3.9) behind the Vim nucleus and 1.99 ± 1.23 mm (range: 0.7-4.4) below it. The mean vector distance ± SD between the Vim nucleus and the Raprl was 3 ± 1.38 mm (range: 1.25-5.2). Conclusion: The Raprl can be easily seen on colored FA maps and constitute a reliable landmark for the borders of the Vim nucleus.

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Section: Discussionmentioning

confidence: 99%

Prelemniscal Radiations: A New Reliable Landmark of the Thalamic Nucleus Ventralis Intermedius Location?

Lefranc

Carron²,

Régis³

2015

Stereotact Funct Neurosurg

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“…After L-dopa was discovered and administered to patients with PD in the 1960s, the need for surgery was dramatically decreased. Even if the value of the STN and GP had been unknown in the 1990s, neurosurgeons could have discovered it simply by stimulating these areas, as microelectrodes were available by the 1960s [165][166][167]. That is the way much of the research on movement disorders proceeded.…”

Section: Laitinen Et Al Again Stated In 1992mentioning

confidence: 99%

“…In 1979, Cooper implanted electrodes for DBS and tried various frequencies in a number of procedures including DBS of the thalamus and electrical stimulation of the cerebellum [46,197,198]. Beginning in the 1960s, electrostimulation was used for confirming the needle placement for thalamic lesions [63,[165][166][167].…”

Section: Claimmentioning

confidence: 99%

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The Development of Deep Brain Stimulation for Movement Disorders

Greek¹

2012

J Clinic Res Bioeth

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The development of deep brain stimulation has revolutionized care for patients with movement disorders like Parkinson's disease. Many areas of science contributed to this technology but one area, the use of animal models, has been cited as vital. We review these claims as well as the history of the discoveries that eventually led to deep brain stimulation in an attempt to ascertain: 1) the contributions of animal models; 2) the contributions from humanbased research and observation; and the role of advances in the engineering, physics, and computer science. We distinguish between advances and discoveries that were, or at least appear to be, dependent on animal models and those where animals were involved but that could have occurred, and/or were occurring simultaneously, with humanbased research. We conclude that animal-based research played a role in defining gross anatomy in the 19 th and early 20 th centuries, but that essentially all subsequent advances were human-based or secondary to advances in the physical and applied sciences. This has historical, funding, and ethical implications as the development of deep brain stimulation is cited as an example of the importance of animal-based research and a reason for continued social and financial support of animal models in general as opposed to clinical research, other human-based research modalities, and the various disciplines of the physical and applied sciences.

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“…Common observations reported by several authors in the process of performing thalamotomies and subthalamotomies in awake patients were that "lowfrequency" stimulation could exacerbate tremor whereas "high-frequency" stimulation resulted in an improvement of that symptom. 2,46,53,73,83,95 In 1963 in France, neurophysiologist Albe-Fessard, 2 who pioneered the technique of subcortical semimicrorecording, reported that stimulation in the region of the ventrointermediate nucleus of the thalamus at frequencies of 100-200 Hz would effectively inhibit tremor in parkinsonian patients. In the same year, psychiatrist Robert Heath from Tulane University in New Orleans published a paper, "Electrical self-stimulation of the brain in Man;" 48 electrodes were implanted in the caudate, septal area, amygdala, central medial thalamus, and various areas of the hypothalamus to study "rewarding" and "aversive" reactions at various current intensities.…”

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confidence: 99%

Deep brain stimulation between 1947 and 1987: the untold story

Hariz

Blomstedt

Zrinzo

2010

FOC

199

120

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Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery. Movement disorders are well-established indications for DBS, and a number of other neurological and psychiatric indications are currently being investigated. Numerous contemporary opinions, reviews, and viewpoints on DBS fail to provide a comprehensive account of how this method came into being. Misconceptions in the narrative history of DBS conveyed by the wealth of literature published over the last 2 decades can be summarized as follows: Deep brain stimulation was invented in 1987. The utility of high-frequency stimulation was also discovered in 1987. Lesional surgery preceded DBS. Deep brain stimulation was first used in the treatment of movement disorders and was subsequently used in the treatment of psychiatric and behavioral disorders. Reports of nonmotor effects of subthalamic nucleus DBS prompted its use in psychiatric illness. Early surgical interventions for psychiatric illness failed to adopt a multidisciplinary approach; neurosurgeons often worked “in isolation” from other medical specialists. The involvement of neuro-ethicists and multidisciplinary teams are novel standards introduced in the modern practice of DBS for mental illness that are essential in avoiding the unethical behavior of bygone eras. In this paper, the authors examined each of these messages in the light of literature published since 1947 and formed the following conclusions. Chronic stimulation of subcortical structures was first used in the early 1950s, very soon after the introduction of human stereotaxy. Studies and debate on the stimulation frequency most likely to achieve desirable results and avoid side effects date back to the early days of DBS; several authors advocated the use of “high” frequency, although the exact frequency was not always specified. Ablative surgery and electrical stimulation developed in parallel, practically since the introduction of human stereotactic surgery. The first applications of both ablative surgery and chronic subcortical stimulation were in psychiatry, not in movement disorders. The renaissance of DBS in surgical treatment of psychiatric illness in 1999 had little to do with nonmotor effects of subthalamic nucleus DBS but involved high-frequency stimulation of the very same brain targets previously used in ablative surgery. Pioneers in functional neurosurgery mostly worked in multidisciplinary groups, including when treating psychiatric illness; those “acting in isolation” were not neurosurgeons. Ethical concerns have indeed been addressed in the past, by neurosurgeons and others. Some of the questionable behavior in surgery for psychiatric illness, including the bygone era of DBS, was at the hands of nonneurosurgeons. These practices have been deemed as “dubious and precarious by yesterday's standards.”

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Electrophysiological studies of some deep cerebral structures in man

Cited by 77 publications

References 5 publications

Prelemniscal Radiations: A New Reliable Landmark of the Thalamic Nucleus Ventralis Intermedius Location?

Prelemniscal Radiations: A New Reliable Landmark of the Thalamic Nucleus Ventralis Intermedius Location?

The Development of Deep Brain Stimulation for Movement Disorders

Deep brain stimulation between 1947 and 1987: the untold story

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