Electroporation: An Avenue for Transdermal Drug Delivery

Charoo, Naseem A.; Rahman, Ziyaur; Repka, Michael A.; Murthy, S. Narasimha

doi:10.2174/156720110791011765

Cited by 93 publications

(55 citation statements)

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“…When applied to the skin, these high-energy pulses generate transient aqueous pores in the stratum corneum. These pores are responsible for the increase of skin permeability, thereby increasing the penetration of the drugs, especially macromolecules and hydrophilic drugs (Charoo et al, 2010). The electrical pulses are primarily applied using plate electrodes placed on the skin's surface.…”

Section: Electroporationmentioning

confidence: 99%

Topical Administration of Anticancer Drugs for Skin Cancer Treatment

Taveira¹,

Lopez²

2011

Skin Cancers - Risk Factors, Prevention and Therapy

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Section: Electroporationmentioning

confidence: 99%

Topical Administration of Anticancer Drugs for Skin Cancer Treatment

Taveira¹,

Lopez²

2011

Skin Cancers - Risk Factors, Prevention and Therapy

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“…Therefore, in the recent past, physical penetration enhancement techniques including ionophoresis, sonophoresis, electroporation, and laser irradiation gained attention in transdermal drug delivery research. The therapeutic effects of above-mentioned electrically assisted techniques, used alone as well in combination or further, in conjunction with chemical enhancers, for transdermal drug delivery were intensively investigated [110,[142][143][144][145][146][147]. Furthermore, hydrogels proved to be suitable formulations for assisted transdermal delivery by ionophoresis, sonophoresis, and electroporation due to their advantageous characteristics such as ease of loading into the device, suitability with the electrode design, good flexibility and fitting with the skin contour, strength, transparency, stability, and high electrical conductivity, which is attributed to their high water content [116,148,149].…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Cellulose-Derivatives-Based Hydrogels as Vehicles for Dermal and Transdermal Drug Delivery

Vlaia¹,

Coneac²,

Olariu³

et al. 2016

Emerging Concepts in Analysis and Applications of Hydrogels

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The use of water-soluble polymers of natural, semisynthetic, and synthetic origin for dermal and transdermal drug delivery systems is manifold. Among the most used biopolymers in the formulation of skin preparations, the cellulose ether derivatives as representatives of semisynthetic polymers distinguish through their specific physicochemical properties, by which the pharmacist can select the appropriate cellulose derivative for a particular purpose. The hydrogels containing cellulose derivatives as gelling agents are widely used as water-soluble ointment bases, because they usually associate the characteristics of both conventional and innovative hydrogels, including especially safety, biocompatibility, biodegradability, and a relatively easy way of preparation and low price. The present chapter describes the following issues: the physicochemical properties of water-soluble cellulose derivatives in relationship with their type and grade; physical and chemical properties of cellulose-derivatives-based hydrogels and their compatibility with other auxiliary substances commonly used in the formulation of pharmaceutical hydrogels; the development and manufacturing of these hydrogels on both small and large scales; the characterization of cellulose derivatives hydrogels as pharmaceutical dosage forms through different compendial and noncompendial methods; and well-recognized and novel applications of cellulosederivatives-based hydrogels for dermal and transdermal drug delivery.

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“…Studies have shown that pulses as short as 1 ms result in up to four orders of magnitude of increase in the transdermal transport of charged molecules [24].…”

Section: Figure 5 Techniques To Optimize Drug Permeation Across the mentioning

confidence: 99%

Identifying Present Challenges to Reliable Future Transdermal Drug Delivery Products

Giannos

2015

Ther. Deliv.

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Transdermal systems have become an accepted means of drug delivery, offering clinical benefits over other dosage forms. Although transdermal delivery has been very successful as a controlled release technology platform, there are a number of challenges that prevent this delivery route from achieving its fullest commercial potential. Additionally, beginning in 1997, transdermal drug delivery companies aligned with life science industries to deliver large molecules, peptides and proteins through the skin, which is difficult due to the skin barrier properties. A number of methods and technologies have been conceived to overcome the skin barrier. Among these are mechanical, chemical and thermal permeation enhancement techniques. These methods are briefly discussed as well as future directions for transdermal therapies.

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Electroporation: An Avenue for Transdermal Drug Delivery

Cited by 93 publications

References 0 publications

Topical Administration of Anticancer Drugs for Skin Cancer Treatment

Topical Administration of Anticancer Drugs for Skin Cancer Treatment

Cellulose-Derivatives-Based Hydrogels as Vehicles for Dermal and Transdermal Drug Delivery

Identifying Present Challenges to Reliable Future Transdermal Drug Delivery Products

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