Electrospinning as a versatile method for fabricating coreshell, hollow and porous nanofibers

Khajavi, Ramin; Abbasipour, Mina

doi:10.1016/j.scient.2012.10.037

Cited by 182 publications

(116 citation statements)

References 78 publications

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“…highly porous three dimensional surface, high surface-to-volume ratios, interconnected porosity with tuneable pore dimensions, found tremendous applications in different biomedical fields [9][10][11][12][13][14][15]. Various electrospinning parameters modulate the fiber diameter and thickness, which may affect sustained and controlled release profiles [16][17][18]. To increase the diffusional path between the drug and dissolution medium, eventually the concept of multi-layered electrospun fibers was developed, which enabled better control in release [13,14].…”

Section: Introductionmentioning

confidence: 99%

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.

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Section: Introductionmentioning

confidence: 99%

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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“…This method produces high surface area (Zhu et al 2011), permeability (Cengiz et al 2009), thermal resistance (Bordes et al 2009), and crystallinity, as well as finer and continuous fiber materials with sizes ranging from microns to several nanometers (Khajavi and Abbasipour 2012). Due to its capability, electrospinning has been widely used for the production of cellulose microfiber (MF); however, most of the previous studies focused on using commercialized cellulose as a starting material (Quan et al 2010;Freire et al 2011;Chen et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Spinnability of Oil Palm Mesocarp Fiber Cellulose Solution for the Production of Microfiber

Yasim-Anuar¹,

Ariffin²,

Norrrahim³

et al. 2016

BioResources

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Cellulose microfiber (MF) formation by electrospinning is affected by several factors. In this paper, fabrication of MF from oil palm mesocarp fiber (OPMF), a biomass residue abundantly available at the palm oil mill, was conducted by electrospinning. The effect of OPMF-cellulose solution properties on the spinnability of the solution was determined. Extracted cellulose from OPMF was dissolved in four different formulations of ionic liquids:DMF at cellulose concentrations of 1% to 9% (w/v). Scanning electron microscopy (SEM) analysis showed that MF formed had diameter sizes ranging from 200 to 500 nm. MF was formed only at 6% (w/v) cellulose concentration, when DMF was mixed in the solution. The results showed that cellulose concentration and viscosity played major roles in the spinnability of cellulose solution, in which too high viscosity of the cellulose solution caused failure of the electrospinning process and eventually affected the formation of MF. The characteristics of MF obtained herein suggest the potential of OPMF cellulose as a starting material for the production of MF.

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“…ion in TiO 2 lattice without destroying the crystal structure, thereby stabilizing the anatase phase. Recently, Zn-doped TiO 2 powder was synthesized by various preparative methods like sol-hydrothermal (Yang et al 2010;Zhu et al 2012); sol-gel and solid phase reaction (Liu 2005); homogeneous hydrolysis (Ö sterlund et al 2009); controlled hydrolysis of titanium(IV) butoxide (Mahata et al 2011); electrospinning (Khajavi and Abbasipour 2012); assembly process based on Ligand exchange reaction (Xu et al 2005) micro emulsion (Sanchez-Dominguez et al 2015) and sol-gel method (Seabra et al 2011;Chauhan et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and photocatalytic applications of Zn-doped TiO2 nanoparticles by sol–gel method

Aware¹,

Jadhav²

2015

Appl Nanosci

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Mesoporous, nanocrystalline, Zinc-doped TiO 2 nanoparticles were synthesized by surfactant-assisted solgel method. The X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), and UV-VIS spectrometer techniques were used to characterize the synthesized products. XRD results confirm the formation of the anatase phase for the TiO 2 nanoparticles, with crystallite sizes in the range of 12.6-18.1 nm. The small crystallite size and doping with Zinc ion inhibit phase transformation and promote the growth of the TiO 2 anatase phase. The SEM and TEM micrographs revealed the spherical-like morphology with average diameter of about 12-18 nm which is in agreement with XRD results. The optical study shows that doping ions lead to an increase in the absorption edge wavelength and a decrease in the band gap energy of titania. Photocatalytic activity of the synthesized nanomaterials was successfully tested for photodegradation of methyl red as model pollutant under UV light. The photocatalytic activity results confirm that the doped nanoparticles show higher activity than undoped titania. The small grain size, high crystallinity, high specific surface area and decrease in the band gap energy of doped titania may be responsible for the high photocatalytic activity.

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Electrospinning as a versatile method for fabricating coreshell, hollow and porous nanofibers

Cited by 182 publications

References 78 publications

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Factors Affecting Spinnability of Oil Palm Mesocarp Fiber Cellulose Solution for the Production of Microfiber

Synthesis, characterization and photocatalytic applications of Zn-doped TiO2 nanoparticles by sol–gel method

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