Electrospinning of chitosan from different acid solutions

Salazar-Brann, Sergio A.; Patiño‐Herrera, Rosalba; Navarrete-Damián, Jaime; Louvier-Hernández, José Francisco

doi:10.3934/bioeng.2021011

Cited by 22 publications

(13 citation statements)

References 45 publications

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“…Briefly, electrospinning involves the generation of a charged polymeric biomaterial jet that is ejected through a high-voltage electric field; randomly rotating polymeric fibers rest on a grounded complex to create a scaffold. The solvent evaporates, and the polymer fibers solidify [ 71 , 72 ]. It is important to consider every single parameter, polymer molecular weight, voltage, the distance between the capillary and collector, polymer concentration, solution conductivity, and solvent volatility, all of which impact the characteristics and properties of the fibers [ 73 ].…”

Section: Biofabrication Approaches Used To Develop Artificial Scaffoldsmentioning

confidence: 99%

“…Some current bio-printer models mimic a sterile environment, such as a biosafety cabinet, using HEPA filters and UV lamps for sterilization. This process can be observed because of their clear windows [ 72 ].…”

Section: Biofabrication Approaches Used To Develop Artificial Scaffoldsmentioning

confidence: 99%

“…Disadvantages: initial investment in the instrument, the use of toxic solvents, and mechanical instability [ 72 ].…”

Section: Biofabrication Approaches Used To Develop Artificial Scaffoldsmentioning

confidence: 99%

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Artificial Scaffolds in Cardiac Tissue Engineering

Roacho-Pérez

Garza-Treviño

Moncada‐Saucedo

et al. 2022

Life

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Cardiovascular diseases are a leading cause of death worldwide. Current treatments directed at heart repair have several disadvantages, such as a lack of donors for heart transplantation or non-bioactive inert materials for replacing damaged tissue. Because of the natural lack of regeneration of cardiomyocytes, new treatment strategies involve stimulating heart tissue regeneration. The basic three elements of cardiac tissue engineering (cells, growth factors, and scaffolds) are described in this review, with a highlight on the role of artificial scaffolds. Scaffolds for cardiac tissue engineering are tridimensional porous structures that imitate the extracellular heart matrix, with the ability to promote cell adhesion, migration, differentiation, and proliferation. In the heart, there is an important requirement to provide scaffold cellular attachment, but scaffolds also need to permit mechanical contractility and electrical conductivity. For researchers working in cardiac tissue engineering, there is an important need to choose an adequate artificial scaffold biofabrication technique, as well as the ideal biocompatible biodegradable biomaterial for scaffold construction. Finally, there are many suitable options for researchers to obtain scaffolds that promote cell–electrical interactions and tissue repair, reaching the goal of cardiac tissue engineering.

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Section: Biofabrication Approaches Used To Develop Artificial Scaffoldsmentioning

confidence: 99%

Section: Biofabrication Approaches Used To Develop Artificial Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

Artificial Scaffolds in Cardiac Tissue Engineering

Roacho-Pérez

Garza-Treviño

Moncada‐Saucedo

et al. 2022

Life

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“…To implement electrospinning the four basic elements required are: a dosing pump with a syringe (containing the polymer solution inside), a needle (Taylor cone), a collector drum (can be a plate, metal screen, or rotating mandrel), and a high-voltage power supply (up to 30 kV). Briefly, electrospinning involves the generation of a charged polymer jet that is ejected through a high-voltage electric field; randomly rotating polymeric fibers rest on a grounded complex to create a scaffold, the solvent is evaporated, and the fibers of the polymer solidify [103,104]. It is important to consider every single parameter, like chitosan molecular weight, voltage, the distance between capillary and collector, polymer concentration, solution conductivity, and solvent volatility, which impact on characteristics and properties of the fibers [105].…”

Section: Electrospinningmentioning

confidence: 99%

Chitosan Scaffolds for Cardiac Tissue Engineering

Roacho-Pérez¹,

Garza-Treviño²,

Moncada‐Saucedo³

et al. 2022

Preprint

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Cardiovascular diseases are the leading cause of death worldwide. Cardiovascular diseases complication can give rise to myocardial infarction which produces cell death by blockage of blood flow, leading to loss of heart function. Current treatments directed at heart repair have several disadvantages such as the lack of donors for heart transplantation or the use of non-bioactive inert materials for replacement of the damage tissue. New treatment strategies involve stimulation of heart tissue regeneration with the use of bioactive materials like chitosan, in combination with cells and biochemical factors. Chitosan scaffolds have the necessary proprieties of biocompatibility, porosity, and biodegradation, that imitates the heart extracellular matrix. Chitosan scaffolds physical proprieties, such as electrical conductivity and mechanical proprieties, can be improved by different preparation techniques and by the functionalization with other materials.

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“…Chitosan formed by partial chitin deacetylation is a polysaccharide that possesses essential biocompatibility and pH-variable biodegradability, and considered a great wound healing promoter in regenerative medicine [ 38 , 39 ]. However, there exist specific technological difficulties associated with chitosan fiber manufacturing via electrospinning, since the molding process often requires the injection of toxic acidic reagents, such as trifluoroacetic, acetic, or hydrochloric acids [ 40 , 41 ], to enhance the stretching of the jet from high-molecular solutions. The solution to this key problem has been found by combining chitosan with the synthetic polymers (poly(vinyl alcohol) and poly(ethylene oxide)) with lower molecular weight and good molding ability conditioned by special conductivity and viscosity of their aqueous solutions [ 42 , 43 , 44 ].…”

Section: Modern Polymer-based Fibrous Compositesmentioning

confidence: 99%

Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering

2021

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Currently, the significantly developing fields of tissue engineering related to the fabrication of polymer-based materials that possess microenvironments suitable to provide cell attachment and promote cell differentiation and proliferation involve various materials and approaches. Biomimicking approach in tissue engineering is aimed at the development of a highly biocompatible and bioactive material that would most accurately imitate the structural features of the native extracellular matrix consisting of specially arranged fibrous constructions. For this reason, the present research is devoted to the discussion of promising fibrous materials for bone tissue regeneration obtained by electrospinning techniques. In this brief review, we focus on the recently presented natural and synthetic polymers, as well as their combinations with each other and with bioactive inorganic incorporations in order to form composite electrospun scaffolds. The application of several electrospinning techniques in relation to a number of polymers is touched upon. Additionally, the efficiency of nanofibrous composite materials intended for use in bone tissue engineering is discussed based on biological activity and physiochemical characteristics.

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Electrospinning of chitosan from different acid solutions

Cited by 22 publications

References 45 publications

Artificial Scaffolds in Cardiac Tissue Engineering

Artificial Scaffolds in Cardiac Tissue Engineering

Chitosan Scaffolds for Cardiac Tissue Engineering

Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering

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