Electrospinning of poly(ethylene-co-vinyl alcohol) fibers

Kenawy, El‐Refaie; Layman, John M.; Watkins, Jessica R; Bowlin, Gary L.; Matthews, Janice R.; Simpson, David G.; Wnek, Gary E.

doi:10.1016/s0142-9612(02)00422-2

Cited by 335 publications

(187 citation statements)

References 18 publications

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“…The prepared non-woven web is removable from the grounded collector as a sheet. There are numerous promising research activities in various relevant areas such as composites [6][7][8][9][10][11], sterile filtration [12], wound dressing [13,14], wound healing [15], tissue engineering [16][17][18][19] and semiconductors [20]. This technique is relatively new in the field of medical industry and ES is quite slightly known in pharmaceutical technology, where most of the relevant papers deal with sustained drug release [21].…”

Section: Introductionmentioning

confidence: 99%

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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Abstract. Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a potential orally dissolving dosage form. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultra-fast dissolution in water based media. Poly(vinyl-alcohol) of low molecular weight was found to be the most appropriate for this purpose. Morphology of the prepared nanofibers was characterized by scanning electron microscope as a function of viscosity and drug content. Diameters of the fibers were between 100 and 300 nm with narrow distribution. In vitro drug release of the webs was immediate (less than 30 s) after immersion independently of their drug content owing to the formed huge surface area, while cast films with the same compositions and commercial tablets needed 30 min or more for complete dissolution. The developed technology for the preparation of orally dissolving web (ODW) formulations is a promising way for producing effective and acceptable dosage forms for children, older people and patients with dysphagia.

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Section: Introductionmentioning

confidence: 99%

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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“…Below a threshold value the jet breaks and defects such as beads and droplets have been observed [59][60][61] Electro spinning of polymers such as polyethylene oxide (PEO), polyacrylonitrile (PAN) 62 and poly-DL-lactic acid (PDLA) 63 is difficult below certain concentration levels. Geng et al 44 observed the formation of uniform chitosan fibres containing fewer defects with the increase in the solution viscosity.…”

Section: Parameters Related To Solutionmentioning

confidence: 99%

“…Lou et al 36 observed that when the tip to collector distance is less than 10cm, the same electrical field can't spin the fibres because the solvent is not completely evaporated. Theron et al 61 used a sharp needle to position and align individual polymer nano fibres into parallel arrays. Sundary et al 78 aligned the as-spun nano fibres in parallel and cross patterns by using an insulated cylinder substrate (speed 2000 rpm) attached to the axle of a DC motor.…”

Section: Collector Distance and Geometrymentioning

confidence: 99%

Nano Fibres by Electro spinning: Properties and Applications

Nayak¹,

Padhye²

2017

JTEFT

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Electro spinning is a simple and versatile technique applicable to a wide range of polymers and solvents for the production of materials in nanometer scale. The nano fibrous materials produced by electro spinning process exhibit novel and significantly improved physical, chemical and biological properties. The small fibre diameter and the porous structure of the electrospun surfaces enable them for a wide range of applications such as wound dressing, tissue engineering scaffolds, vascular grafts, filters, membranes and sensors. In this article the principle, setup, materials used and the factors affecting the electro spinning process have been described. Also the properties & applications of electrospun fibres and the limitations & future scope of electro spinning process have been highlighted.

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“…PEVA needs to be dissolved in dimethyl sulfoxide or lower alcohols. Kenawy et al have prepared the PEVA solution by dissolving PEVA in a 70% alcohol solution (rubbing alcohol) at 65 C for electrospinning [148]. Interestingly, the polymer tends to precipitate when sitting in room temperature for several hours.…”

Section: Synthetic Polymeric Nanofibrous Scaffoldsmentioning

confidence: 99%

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Li¹,

Shanti²,

Tuan³

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

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Electrospinning of poly(ethylene-co-vinyl alcohol) fibers

Cited by 335 publications

References 18 publications

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nano Fibres by Electro spinning: Properties and Applications

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

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