Electrospun composite nanofibers for functional applications

Sawicka, Katarzyna M.; Gouma, Perena

doi:10.1007/s11051-005-9026-9

Cited by 160 publications

(85 citation statements)

References 81 publications

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“…Synthetic polymers with good processability and good mechanical properties can be mixed with natural polymers producing an increase in cellular attachment and biocompatibility [4]. Multicomponent fibers can be obtained mainly by two techniques [5]: direct electrospinning of polymers solution (in a single-needle configuration, if a mixture of polymers is co-dissolved in the electrospinning solution or a multi-needle configuration in which the polymer solutions are separated in parallel or concentric syringes) and post-treatment of the single-component electrospun fibers (which can include coating with other inorganic-polymer layers [6,7], grafting [8], crosslinking [9], chemical vapour deposition [10], functionalization with other (bio)polymers [11]). In addition to the new physico-chemical properties that arise from using various components, a variety of fiber structures can be obtained such as core-shell fibers, micro/nanotubes, interpenetrating phase morphologies (matrix dispersed or co-continuous fibers) [12,13], nanoscale morphologies (spheres, rods, micelles, lamellae, vesicle tubules, and cylinders) [14] and multilayered constructs (either with different composition or different fiber diameter) [15,16].…”

Section: Introductionmentioning

confidence: 99%

Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers

Natu

Sousa

Gil

2010

International Journal of Pharmaceutics

148

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Bicomponent fibers of two semi-crystalline (co)polymers, poly(ε-caprolactone), PCL and poly(oxyethylene-b-oxypropylene-b-oxyethylene), Lu were obtained by electrospinning. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations (below and above the drug solubility limit in polymer) in order to determine the effect of drug solubility in polymer, drug state, drug loading and fiber composition on fiber morphology, drug distribution and release kinetics. The high loadings fibers (with drug in crystalline form) showed higher burst and faster release than low drug content fibers, indicating the release was more sustained when the drug was encapsulated inside the fibers, in amorphous form. Moreover, timolol maleate was released faster than acetazolamide, indicating that drug solubility in polymer influences the partition of drug between polymer and elution medium, while fiber composition also controlled drug release. At low loadings, total release was not achieved (cumulative release percentages smaller than 100 %), suggesting that drug remained trapped in the fibers. The modeling of release data implied a three stage release mechanism: a dissolution stage, a desorption and subsequent diffusion through water filled pores, followed by polymer degradation control.

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Section: Introductionmentioning

confidence: 99%

Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers

Natu

Sousa

Gil

2010

International Journal of Pharmaceutics

148

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“…Alumina nanofibers can be synthesized with metallic aluminum particles [10,22,43,59], Al alkoxides [ 36; 46, 17] or its salts [27,45,47,48,49,51] as the starting materials. Other starting materials that have been used include Al pentanedionate, [50], aluminum hydroxide, [52], alumina composite, [53] aluminum film, [42] and sodium aluminate. [54] However, whatever the starting materials used in the synthesis, the nanofibrous boehmite intermediate will have to be formed [22] for the formation of the nanofibers as mentioned above.…”

Section: Hydrothermal and Sol Gel Processesmentioning

confidence: 99%

“…In the case of the melt the discharged jet solidifies when it travels in the air. Many reports have appeared in the literature in the past few years on the fabrication of alumina nanofibers as the viscosity of the boehmite gel is well suited for the electrospinning technique [5,34,48,50,51,53]. The gel solution for the spinning consisted of nanofibrous colloid prepared by the sol-gel or hydrothermal processes, however, the precursor mixture may also be used.…”

Section: Electrospinningmentioning

confidence: 99%

Synthesis of Alumina Nanofibers and Composites

Noordin¹,

Liew²

2010

Nanofibers

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IntroductionAlumina, Al 2 O 3 , is a ceramic metal oxide of great importance as building material, refractory material, electrical and heat insulator, attributed to its high strength, corrosion resistance, chemical stability, low thermal conductivity, and good electrical insulation. One phase of alumina, the -phase is widely used as catalyst, catalyst support and adsorbent because its high porosity and surface area. It is conventionally prepared by heating the hydrated trihydroxides, gibbsite and bayerite, to temperature of > 1000 o C to obtain the -alumina, corundum, a material with great hardness and low surface area. The trihydroxides, gibbsite, bayerite, both are Al(OH) 3. nH 2 O and the monohydroxyl oxide, boehmite, AlO(OH)·αH 2 O, have the monoclinic crystal structure with similar lattice parameters (a=0.866 nm, b=0.506 nm, c=0.983 nm, =94°34′ in boehmite, a=0.868 nm, b=0.507 nm, c=0.972 nm, =94°34′ in gibbsite, and a=0.867 nm, b=0.506 nm, c=0.942 nm, =90°26′ in bayerite [1,2]. In the process of heat treatment, the trihydroxide undergoes a series of transformations. It loses the water of hydration, then dehydroxalate at < 300 o C to form the monohydroxyl oxide boehmite, AlO(OH), which on further heating to increasingly higher temperatures, changes to the transition aluminas, including the -, -, -, and -phases, which then transform finally to the -form. These transition aluminas are crystalline solids with high porosity and surface areas as well as acidic and basic properties, which make them suitable as adsorbents, catalyst, catalyst support and fabricated into filtration membranes as well as used as fillers or components in polymer/ inorganic composite materials with enhanced mechanical properties. The conventional alumina as obtained are usually powder of particulates. These could be fabricated into alumina fibers by various method, through melt growth techniques including the internal crystallization method and extrusion, electrospraying [3] and electrospinning [4][5][6][7][8] have been developed for producing Al 2 O 3 fibers. The high surface areas of transition aluminas are due to the presence of pores. These pores are irregular in sizes and size distributions, and are mainly micropores of diameter less than 2 nm. Since the synthesis of mesoporous materials was first reported in the late 1980s , a number of methods for the synthesis of mesoporous alumina have been reported [8,9]. More recently, interest in nano-materials and nanotechnology has spurred a fury of investigations

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“…Owing to these features, electrospun nanofiber mats have the potential for application in a wide variety of fields, including apparel [3], biomedicine [4], composite and filter materials [5,6], and sensors etc [7,8]. However, conventional electrospinning is capable of producing nanofiber nonwoven mats only at relatively low yields, which greatly affects their application prospects [9,10]. Only when nanofiber yarns become suitable for being subjected to regular textile processes such as weaving, knitting, and embroidery would they find a place in the high-tech textile market, which is of great commercial significance.…”

Section: Introductionmentioning

confidence: 99%

Combined application of multinozzle air-jet electrospinning and airflow twisting for the efficient preparation of continuous twisted nanofiber yarn

Wang

et al. 2015

Fibers Polym

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This paper presents a new approach for the mass production of nanofiber yarns, which involves the use of a multinozzle air-jet electrospinning system and airflow twisting. In this system, the aggregation, orientation, and continuous bundling of nanofibers are first achieved by applying the principle of conjugate electrospinning. Three-dimensional highspeed rotating airflow is then applied to continuously twist and spin the nanofibers into yarn. In this study, the mechanisms for formation and aggregation of nanofibers using the new air-jet electrospinning system were analyzed. In addition, numerical simulations of the airflow field within the nozzle were performed to understand the airflow characteristics and to study the effects of airflow twisting on nanofiber spinning. The obtained results indicated that the output of nanofiber bundles for the proposed multinozzle air-jet electrospinning system was able to reach 6.642 g/h. The application of three-dimensional rotating airflow enabled continuous production of twisted nanofiber yarns with favorable orientation and uniform twist distribution. Under an air pressure of 0.3 MPa and at a spinning speed of 132.1 m/s, the twist angle, tensile strength, and elongation of the nanofiber yarn were 65.2 o , 74.23 MPa, and 85.55 %, respectively. Thus, it can be concluded that the proposed spinning tenique is practical and efficient for high-speed and large-scale production of nanofiber yarn.

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Electrospun composite nanofibers for functional applications

Cited by 160 publications

References 81 publications

Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers

Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers

Synthesis of Alumina Nanofibers and Composites

Combined application of multinozzle air-jet electrospinning and airflow twisting for the efficient preparation of continuous twisted nanofiber yarn

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