Electrospun heparin-loaded nano-fiber sutures for the amelioration of achilles tendon rupture regeneration: <i>in vivo</i> evaluation

Ye, Ya-Jing; Zhou, Yaqing; Jing, Zhuoyuan; Xu, Yifan; Yin, Da‐Chuan

doi:10.1039/d1tb00162k

Cited by 12 publications

(4 citation statements)

References 53 publications

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“…Researchers have recently combined electrospun nanofibers with emerging materials, such as minerals, metals, growth factors, stem cells, drugs and nanoparticles, to enhance further their physical and chemical properties and biological activities [ 110 ]. The structure and porosity of the scaffolds should promote cell activities and the formation of new tissues [ 111 ].…”

Section: Electrospun Fiber Materials For Tendon Repairmentioning

confidence: 99%

Functional biomaterials for tendon/ligament repair and regeneration

Tang

Wang

Xiang

et al. 2022

Regenerative Biomaterials

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With an increase in life expectancy and the popularity of high-intensity exercise, the frequency of tendon and ligament injuries has also increased. Owing to the specificity of its tissue, the rapid restoration of injured tendons and ligaments is challenging for treatment. This review summarises the latest progress in cells, biomaterials, active molecules, and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of natural polymers, synthetic polymers, and composite materials has boosted the use of scaffolds. In addition, the development of electrospinning and hydrogel technology has diversified the production and treatment of materials. First, this paper briefly introduces the structure, function, and biological characteristics of tendons/ligaments. Then, it summarises the advantages and disadvantages of different materials, such as natural polymer scaffolds, synthetic polymer scaffolds, composite scaffolds, and ECM-derived biological scaffolds, in the application of tendon/ligament regeneration. We then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration engineering. Finally, we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.

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Section: Electrospun Fiber Materials For Tendon Repairmentioning

confidence: 99%

Functional biomaterials for tendon/ligament repair and regeneration

Tang

Wang

Xiang

et al. 2022

Regenerative Biomaterials

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“…Electrospinning technology can uniformly disperse various functional molecules on each extracellular matrix (ECM)-like 3D staggered microfiber structure, so the nanoscale interwoven fibers obtained can effectively alleviate the problem of low application efficiency caused by uneven distribution of functional molecules or poor loading, and help long-lasting release [9,10]. In addition, the unique advantages of direct, continuous preparation and great controllability of electrospinning provide more possibilities for its application [11][12][13]. It is worth noting that the nanocomposite fiber membrane constructed by electrospinning technology has the softness, water absorption, water retention and biocompatibility of similar tissues of hydrogel systems while maintaining the ECM-like 3D fiber structure, large specific surface area and flexibility [14,15].…”

Section: Introductionmentioning

confidence: 99%

Construction of bioactive electrospun microfibers with VEGF to facilitate the repair of infected wounds

Lin,

jiashaochuan,

Zhou

et al. 2024

Preprint

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Biomimetic dressings are considered as one of the ideal medical dressings to combat bacterial infections, shorten the tissue regeneration process, and facilitate wound repair. Researchers are committed to developing a new generation of wound dressings with unique functions to promote wound repair and healing. Here, a strategy for composite nanofiber membrane construction based on natural biopolymers HA, Gel and PLGA with carrying vascular endothelial growth factor (VEGF) was provided for pro-angiogenic wound repair. The composite nanofiber membrane prepared by electrospinning technology can maintain its biomimetic properties and biochemical properties of the functional factors. The enhanced mechanical properties and flexibility enable it to fit the wound and have great biocompatibility. In addition, the highly efficiently loaded VEGF can be controllable released and targeted to the wound area, thereby promoting the exchange of nutrients and oxygen, proliferation and migration of endothelial cells, and the formation of vascular lumen, effectively accelerating tissue repair and wound healing while avoiding unnecessary drug diffusion. Therefore, composite nanofiber dressing of VEGF@PAG can break through the limitations of traditional patches and become ideal candidates for wound healing and related biomedical applications.

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“…Traditional surgical methods for rotator cuff repair could not achieve satisfactory results, especially the incidence of rotator cuff tissue non‐union and rotator cuff re‐tear much high after the repair of large‐area rotator cuff injuries. In recent years, domestic and foreign scholars have successively launched new explorations and proposed the use of stents to repair rotator cuff injuries, which is attracting widespread attention 9,10 …”

Section: Introductionmentioning

confidence: 99%

“…In recent years, domestic and foreign scholars have successively launched new explorations and proposed the use of stents to repair rotator cuff injuries, which is attracting widespread attention. 9,10 So far, there are many methods for preparing scaffolds according to the characteristics and structure of materials, such as micro and nanoparticles, hydrogels, nanofibers and 3D structures. [11][12][13][14] The electrospun scaffold material has a large specific surface area, higher porosity and better pore connectivity.…”

mentioning

confidence: 99%

A novel high mechanical and excellent hydrophilic electrospun polyurethane‐silk‐bioactive glass nanofiber film for rotator cuff injury repair

Duan

Ling

Sun

et al. 2021

J of Applied Polymer Sci

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Rotator cuff injury is the most common muscle injury in bone surgery and there was still enormously challenging to completely repair it. Disturbed by mechanical stability and biocompatibility, most implants have failed to relieve symptoms and prevent the development of osteoarthritis. Herein, we have firstly fabricated novel electrospinned nanofiber membranes by integrating the excellent mechanical properties of polyurethane (PU), the good biocompatibility of silk fibroin with the osteogenesis properties of bioactive glass (PSB). The obtained results have exhibited that the PSB nanofiber film possessed excellent mechanical properties with the tensile stress have reached 14.6 MPa and the tensile strain reached 70%, which had extremely remedied the properties of pure silk film (3.8 MPa and the tensile strain 7.9%). Especially, PSB has shown superior hydrophilicity (WCA) than silk (WCA) and PU (WCA) groups.Furthermore, we have endowed the PSB with osteogenesis by doping bioactive glass (BG) in it. The PSB film can long-term release functional ions (Si and B ions) that benefit bone tissue repair, and the CCK-8 and ALP results have also confirmed the excellent biocompatibility and osteogenesis of PSB. Hence, the novel PSB film may provide a new treatment strategy for repairing rotator cuff injury.

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Electrospun heparin-loaded nano-fiber sutures for the amelioration of achilles tendon rupture regeneration: in vivo evaluation

Abstract: Peritendinous blood circulation improvement is a challenge to promote healing of ruptured tendons in clinical. Although electrospun membrane or scaffold enable reduce complication such as adhesion, low efficiency, toxicity issues,...

Cited by 12 publications

References 53 publications

Functional biomaterials for tendon/ligament repair and regeneration

Functional biomaterials for tendon/ligament repair and regeneration

Construction of bioactive electrospun microfibers with VEGF to facilitate the repair of infected wounds

A novel high mechanical and excellent hydrophilic electrospun polyurethane‐silk‐bioactive glass nanofiber film for rotator cuff injury repair

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