Electrospun nanofibers modified with Ni-MOF for electrochemiluminescent determination of glucose

Recent advances in glucose-oxidase-based nanocomposites for diabetes diagnosis and treatment

“…1f and g). 27 The sensor has great potential for use in glucose detection. The colorimetric method is simple to use and a rough idea of the glucose content can be made by observing the color change.…”

Cu-MOFs/GOx Bifunctional Probe-Based Synergistic Signal Amplification Strategy: Toward Highly Sensitive Closed Bipolar Electrochemiluminescence Immunoassay

“…It is well known that H 2 O 2 could be catalytically generated by glucose oxidase (GOx) in the presence of glucose . Previous reports have proved that immobilization of enzymes onto the nanomaterials could not only greatly increase the loading amount of the enzymes but also effectively improve their tolerance toward the external environment and prolong their biological activity. , In recent years, a class of porous crystalline metal–organic frameworks (MOFs) with adjustable pore size and rich large pore volume had gained extensive research interest as they are suitable for creating a stable microenvironment by serving as a universal platform for immobilization of various enzymes. , For example, Lu et al designed a highly sensitive ECL sensor for glucose detection by virtue of the large specific surface and porosity of Ni-MOF composite electrospinning nanofibers. The immobilized GOx on Ni-MOF NFs retained its native bioactivity and exhibited fast ECL response to glucose.…”

“…15,16 In recent years, a class of porous crystalline metal−organic frameworks (MOFs) with adjustable pore size and rich large pore volume had gained extensive research interest as they are suitable for creating a stable microenvironment by serving as a universal platform for immobilization of various enzymes. 17,18 For example, Lu et al 19 In general, the reaction of luminol or its analogues with their co-reactants in solution is slow, leading to a weak ECL response. 21 As for the luminol−H 2 O 2 system, the low reaction rate is mainly from the slow rate of the decomposition of H 2 O 2 into its radicals.…”