Electrospun PEGylated PLGA nanofibers for drug encapsulation and release

Zhang, Leqiang; Wang, Zhe; Xiao, Yunchao; Liu, Pengchao; Wang, Shige; Zhao, Yili; Shen, Mingwu; Shi, Xiangyang

doi:10.1016/j.msec.2018.05.045

Cited by 65 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antibacterial properties and microbial susceptibility of the compounds, including the free nanoparticle, used ligand (Hmtzt), cobalt salt, complex 1 and nanocarrier were investigated separately for bacterial Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). These results demanded that the unloaded nanopartlcles (free NPs) has shown no antimicrobial activity, which is in agreement with other reports about PLGA‐based nanocarriers . It is suggested that there was no antibacterial interaction between free NPs and the tested bacteria.…”

Section: Resultssupporting

confidence: 91%

Improvement of the Biological Activity of a New Cobalt(III) Complex through Loading into a Nanocarrier, and the Characterization Thereof

et al. 2019

View full text Add to dashboard Cite

In an effort to use a polymer carrier for the maintenance of biological activity of metal complexes; in this report, a novel cobalt(III) complex, trans‐[Co(en)2(mtzt)2]NO3 (1) was prepared (en=ethylenediamine and Hmtzt=1‐methyl‐1‐H‐1,2,3,4‐tetrazol‐5‐thiol) and fully characterized. A biocompatible di‐block polymer, containing poly lactic‐co‐glycolic acid and poly ethylene glycol (PLGA‐PEG), was employed as the nanocarrier of complex 1 to achieve more efficacy and controlled drug release. Results illustrated that the successful loading of the cobalt complex on the PLGA‐PEG polymer as well as pH dependent drug release with approximately 17%, 58% and 74% release within 168 hours at pH=7.4, 5.8 and 4.8 respectively. Antibacterial properties of complex 1 and corresponding nanocarrier have been determined against gram‐negative (Escherichia coli) and gram‐positive (Staphylococcus aureus) bacteria where the loading of the complex on nanocarrier enhances its antibacterial activity. Their anticancer activity was also evaluated over human ovarian carcinoma cells and compared with cisplatin.

show abstract

Section: Resultssupporting

confidence: 91%

Improvement of the Biological Activity of a New Cobalt(III) Complex through Loading into a Nanocarrier, and the Characterization Thereof

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition, 1% AMX/PLGA-PEG nanofiber scaffolds can inhibit approximately 95.9% growth of penicillin resistance gram-positive Streptococcus aureus at an AMX concentration of 60 μg/mL. The hemolysis and anticoagulant in vitro experiments revealed that they have great hemocompatibility and cytocompatibility [78]. In another study, RuO 4 (ruthenium tetroxide) oxidized herringbone graphite carbon nanofibers (hGCNF) was prepared for surface labeling of antibiotics.…”

Section: Applications Of Nanofibers In Therapeutics Deliverymentioning

confidence: 99%

Electrospinning Nanofibers for Therapeutics Delivery

et al. 2019

View full text Add to dashboard Cite

The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications.

show abstract

“…Lu et al [10] investigated the effects of electrospraying a solution system and concentration of polyethylene oxide (PEO) on the morphologies of the single-drug and dual-drug loaded nanocomposites. Zhang et al [11] reported that the polyethylene glycolation (PEGylation) modification could afford a faster release profile of the encapsulated drug than pure poly(lactic-co-glycolic acid) (PLGA) nanofibers, and the drug-loaded PLGA-PEG nanofibers were able to inhibit the growth of a model bacterium, Staphylococcus aureus . Ramírez-Agudelo et al [12] found that composite nanofibers were easier to obtain an antibacterial property compared to a single polymer system.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Properties of Porous PLA/PEG/Curcumin Composite Nanofibers for Antibacterial Application

et al. 2019

View full text Add to dashboard Cite

Polylactide/polyethylene glycol/curcumin (PLA/PEG/Cur) composite nanofibers (CNFs) with varying ratios of PEG were successfully fabricated by electrospinning. Characterizations of the samples, such as the porous structure, crystalline structure, pore size, wetting property and Cur release property were investigated by a combination of scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and UV spectrophotometer. The antibacterial properties of the prepared porous CNFs against Escherichia coli bacteria were studied. The results showed that with the decrease of PEG in the CNFs, there appeared an evident porous structure on the CNF surface, and the porous structure could enhance the release properties of Cur from the CNFs. When the weight ratio (PEG:PLA) was 1:9, the pore structure of the nanofiber surface became most evident and the amount of Cur released was highest. However, the antibacterial effect of nonporous CNFs was better due to burst release over a short period of time. That meant that the porous structure of the CNFs could reduce the burst release and provide better control over the drug release.

show abstract

Electrospun PEGylated PLGA nanofibers for drug encapsulation and release

Cited by 65 publications

References 41 publications

Improvement of the Biological Activity of a New Cobalt(III) Complex through Loading into a Nanocarrier, and the Characterization Thereof

Improvement of the Biological Activity of a New Cobalt(III) Complex through Loading into a Nanocarrier, and the Characterization Thereof

Electrospinning Nanofibers for Therapeutics Delivery

Preparation, Characterization and Properties of Porous PLA/PEG/Curcumin Composite Nanofibers for Antibacterial Application

Contact Info

Product

Resources

About