Electrospun porous poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate)/lecithin scaffold for bone tissue engineering

Liu, Wei; Jiao, Tiejun; Su, Yuran; Wei, Ran; Wang, Zheng; Liu, Jiacheng; Fu, Na; Sui, Lei

doi:10.1039/d2ra01398c

Cited by 11 publications

(3 citation statements)

References 51 publications

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“…In addition, electrospun porous nanofibers have also attracted great attention in tissue engineering. Liu et al [ 166 ] prepared a porous poly (3-hydroxybutyrate co-4-hydroxybutyrate) (P34HB) scaffold covered with lecithin that self-assembled on the surface of a scaffold by electrospinning technology. Porous scaffolds provided mesenchymal stem cells from bone marrow protection and sufficient three-dimensional space for cell proliferation.…”

Section: Applications Of Electrospun Porous Nanofibersmentioning

confidence: 99%

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang

Cao

et al. 2023

Polymers

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Electrospun porous nanofibers have gained a lot of interest recently in various fields because of their adjustable porous structure, high specific surface area, and large number of active sites, which can further enhance the performance of materials. This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. Firstly, the polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning, namely the template method and phase separation method, are introduced. Secondly, recent applications of electrospun porous nanofibers in air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound and wave absorption, flame retardant, and heat insulation are reviewed. Finally, the challenges and possible research directions for the future study of electrospun porous nanofibers are discussed.

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Section: Applications Of Electrospun Porous Nanofibersmentioning

confidence: 99%

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang

Cao

et al. 2023

Polymers

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“…It was established [ 19 ] that the coating of scaffolds made of the Mg 2 SiO 4 –CuFe 2 O 4 nanocomposite and a layer of PHB increases cell viability, alkaline phosphatase activity, and scaffold mineralization when osteoblast-like cells are cultivated on it. It was also found [ 34 ] that fibrous scaffolds made of the P4HB copolymer by electrospinning significantly facilitate attachment and growth of MSCs isolated from rat bone marrow. The scratch model (mechanical removal of cells on the scaffold surface in the form of a strip of a specified width) also demonstrated that P4HB-fibre scaffolds support MSC migration.…”

Section: Scaffolds From Poly(3-hydroxybutyrate) and Its Copolymers Fo...mentioning

confidence: 99%

“…In another study [ 34 ], scientists used a bilateral critical bone defect of the parietal bone. The diameter of each defect was 5 mm; one of the defects was covered with a fibrous scaffold made of the P4HB copolymer.…”

Section: Scaffolds Based On Poly(3-hydroxybutyrate) and Its Copolymer...mentioning

confidence: 99%

Scaffolds Based on Poly(3-Hydroxybutyrate) and Its Copolymers for Bone Tissue Engineering (Review)

Bonartsev¹,

Voinova²,

Volkov³

et al. 2022

Sovrem Tehnol Med

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Biodegradable and biocompatible polymers are actively used in tissue engineering to manufacture scaffolds. Biomedical properties of polymer scaffolds depend on the physical and chemical characteristics and biodegradation kinetics of the polymer material, 3D microstructure and topography of the scaffold surface, as well as availability of minerals, medicinal agents, and growth factors loaded into the scaffold. However, in addition to the above, the intrinsic biological activity of the polymer and its biodegradation products can also become evident. This review provides studies demonstrating that scaffolds made of poly(3-hydroxybutyrate) (PHB) and its copolymers have their own biological activity, and namely, osteoinductive properties. PHB can induce differentiation of mesenchymal stem cells in the osteogenic direction in vitro and stimulates bone tissue regeneration during the simulation of critical and non-critical bone defects in vivo.

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Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds

Gładysz,

Ubels,

Koch

et al. 2024

Adv Healthcare Materials

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Melt electrowriting (MEW) enables precise scaffold fabrication for biomedical applications. With a limited number of processable materials with short and tunable degradation times, polyhydroxyalkanoates (PHAs) present an interesting option. Here, poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) and a blend of PHBV and poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) (PHBV+P34HB) are successfully melt electrowritten into scaffolds with various architectures. PHBV+P34HB exhibits greater thermal stability, making it a superior printing material compared to PHBV in MEW. The PHBV+P34HB scaffolds subjected to enzymatic degradation show tunable degradation times, governed by enzyme dilution, incubation time, and scaffold surface area. PHBV+P34HB scaffolds seeded with human dermal fibroblasts (HDFs), demonstrate enhanced cell adherence, proliferation, and spreading. The HDFs, when exposed to the enzyme solutions and enzymatic degradation residues, show good viability and proliferation rates. Additionally, HDFs grown on enzymatically pre‐incubated scaffolds do not show any difference in behavior compared those grown on control scaffolds. It is concluded that PHAs, as biobased materials with enzymatically tunable degradability rates, are an important addition to the already limited set of materials available for MEW technology.

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Electrospun porous poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/lecithin scaffold for bone tissue engineering

Abstract: An electrospun P34HB scaffold was prepared and coated with lecithin. As a scaffold for bone tissue engineering, the P34HB/lec scaffold could promote proliferation and osteogenesis of BMSCs in vitro, and also accelerate bone regeneration in vivo.

Cited by 11 publications

References 51 publications

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Scaffolds Based on Poly(3-Hydroxybutyrate) and Its Copolymers for Bone Tissue Engineering (Review)

Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds

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