Electrostatic measurements on a miniaturized fluidized bed

Murtomaa, Matti; Räsänen, Eetu; Rantanen, Jukka; Bailey, A.G.; Laine, E.; Mannermaa, Jukka-Pekka; Yliruusi, Jouko

doi:10.1016/s0304-3886(02)00121-3

Cited by 42 publications

(23 citation statements)

References 9 publications

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“…40 65 The dosage of the powders is based on the powder volume and reproducibility depends on the flow behavior during powder processing, 41 but this can be seriously affected by electrostatic charge. 42 Undesirable adhesion and soiling 70 Another issue caused by electrification is unwanted adhesion, e.g. of dust particles in solar panels (SPs).…”

Section: Hazards Triggered By Electrostatic Discharge (Esd)mentioning

confidence: 99%

Friction, tribochemistry and triboelectricity: recent progress and perspectives

et al. 2014

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Production of electricity by friction is well known but poorly understood and it is the source of electrostatic discharge causing serious accidents. Recent results are in agreement with one of the conflicting views on this problem, according to which triboelectricity in polymers is triggered by mechanochemical and wear or mass transfer phenomena. These results also challenge the widely accepted paradigm of one-way charge transfer that is the basis of the triboelectric series. Experimental results from powerful analytical techniques 10 65 mechanisms leading to solids contact electrification and/or triboelectric charging? The explanation of the production of electrostatic charge comes from a transfer of electrons, ions or both, which are presented in the literature? 16 Poor knowledge on charge accumulation and dissipation 70 mechanisms 17-19 is a root of large-scale personal and property losses, including serious industrial accidents and explosions that are described further in the next section. This is ultimately due to the lack of scientific understanding of the basic phenomena.On the other hand, fundamental electrostatic concepts are well 75 established for semiconductors and metals. 20 When two metals with different work functions are brought into contact, electrons migrate across the interface creating a potential difference between them.

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Section: Hazards Triggered By Electrostatic Discharge (Esd)mentioning

confidence: 99%

Friction, tribochemistry and triboelectricity: recent progress and perspectives

et al. 2014

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“…38 Triboelectrification [39][40][41][42] and triboelectric charging of pharmaceutical powders as a function of surface properties and relative humidity 34,[43][44][45][46] have been investigated. Furthermore, triboelectrification of lactose [47][48][49][50] and glucose 51 is known to occur during the process of spray-drying 52 lactose and mannitol, in miniaturized fluidized bed, 53,54 in powder coating applications 55,56 and during microscale granulation. 57 Additionally, electrostatic charging in lactose monohydrate during melt agglomeration and effects of surfactants on charging 58,59 have been demonstrated.…”

Section: Powder Flow Propertiesmentioning

confidence: 99%

Physical Characterization of Component Particles Included in Dry Powder Inhalers. II. Dynamic Characteristics

Hickey

Mansour

Telko

et al. 2007

Journal of Pharmaceutical Sciences

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“…Bennett et al 24 tested crystalline and spray-dried lactose samples neutralized with a radioactive source in a stainless steel cyclone, obtaining a negative charge in both cases. Murtomaa et al 22 Note from Figure 4 that the absolute value of the volume specific chargeability (mV/0.5 cc) increased as the particle size decreased from the L90 to the M5 grade. For smaller sizes of Cab-O-Sil (ie, EH5, the chargeability appears to plateau with respect to smaller sizes).…”

Section: Resultsmentioning

confidence: 89%

“…In contrast, Watano et al 21 reported that Avicel PH101 exhibited a positive charge, measured by an electrostatic field sensor, when tested dried or as received in a stainless steel fluidized bed. When Murtomaa et al 22 tested Avicel PH200, as received, in an acrylic fluidized bed column (35% RH and 27ºC) using a sensor ring, the powder exhibited a positive charge before and after fluidization.…”

Section: Resultsmentioning

confidence: 99%

Chargeability measurements of selected pharmaceutical dry powders to assess their electrostatic charge control capabilities

2006

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The purpose of this study was to develop an instrument (the Purdue instrument) and the corresponding methodologies to measure the electrostatic charge development (chargeability) of dry powders when they are in dynamic contact with stainless steel surfaces. The system used an inductive noncontact sensor located inside an aluminum Faraday cage and was optimized to measure the charging capabilities of a fixed volume of powder (0.5 cc). The chargeability of 5,5-diphenyl-hydantoin, calcium sulfate dihydrate, cimetidine, 3 grades of colloidal silicon dioxide, magnesium stearate, 4 grades of microcrystalline cellulose, salicylic acid, sodium carbonate, sodium salicylate, spray-dried lactose, and sulfinpyrazone were tested at 4 linear velocities, and the particle size distribution effect was assessed for 3 different grades of colloidal silicon dioxide and 4 different grades of microcrystalline cellulose. The chargeability values exhibited a linear relationship for the range of velocities studied, with colloidal silicon dioxide exhibiting the maximum negative chargeability and with spray-dried lactose being the only compound to exhibit positive chargeability. The instrument sensitivity was improved by a factor of 2 over the first generation version, and the electrostatic charge measurements were reproducible with relative standard deviations ranging from nondetectable to 33.7% (minimum of 3 replicates). These results demonstrate the feasibility of using the Purdue instrument to measure the electrostatic charge control capabilities of pharmaceutical dry powders with a reasonable level of precision.

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Electrostatic measurements on a miniaturized fluidized bed

Cited by 42 publications

References 9 publications

Friction, tribochemistry and triboelectricity: recent progress and perspectives

Friction, tribochemistry and triboelectricity: recent progress and perspectives

Physical Characterization of Component Particles Included in Dry Powder Inhalers. II. Dynamic Characteristics

Chargeability measurements of selected pharmaceutical dry powders to assess their electrostatic charge control capabilities

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