Elevated copper and lowered zinc in the placentae of pre-eclamptics

Brophy, Michael H.; Harris, Norman F.; Crawford, Isaac L.

doi:10.1016/0009-8981(85)90024-5

Cited by 32 publications

(10 citation statements)

References 8 publications

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“…), suggesting that this increase in preeclampsia maybe an exaggerated response of normal pregnancies [92]. Further retrospective studies from Turkey have shown elevation of maternal serum copper levels in preeclampsia after clinical onset of the disease compared to controls (mean ± SD: 159 ± 38 versus 194 ± 52 μ g/L, resp.)…”

Section: Methodsmentioning

confidence: 99%

The Importance of Antioxidant Micronutrients in Pregnancy

Mistry

Williams

2011

Oxidative Medicine and Cellular Longevity

186

188

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Pregnancy places increased demands on the mother to provide adequate nutrition to the growing conceptus. A number of micronutrients function as essential cofactors for or themselves acting as antioxidants. Oxidative stress is generated during normal placental development; however, when supply of antioxidant micronutrients is limited, exaggerated oxidative stress within both the placenta and maternal circulation occurs, resulting in adverse pregnancy outcomes. The present paper summarises the current understanding of selected micronutrient antioxidants selenium, copper, zinc, manganese, and vitamins C and E in pregnancy. To summarise antioxidant activity of selenium is via its incorporation into the glutathione peroxidase enzymes, levels of which have been shown to be reduced in miscarriage and preeclampsia. Copper, zinc, and manganese are all essential cofactors for superoxide dismutases, which has reduced activity in pathological pregnancy. Larger intervention trials are required to reinforce or refute a beneficial role of micronutrient supplementation in disorders of pregnancies.

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Section: Methodsmentioning

confidence: 99%

The Importance of Antioxidant Micronutrients in Pregnancy

Mistry

Williams

2011

Oxidative Medicine and Cellular Longevity

186

188

View full text Add to dashboard Cite

show abstract

“…However, when Cu is associated in the Cu/Zn SOD it functions as an antioxidant expressed in both maternal and fetal tissue (Ali Akbar et al, 1998 ). Studies have shown increased levels of Cu in placenta, maternal serum, and amniotic fluid in preeclamptic women compared to controls (Brophy et al, 1985 ; Dawson et al, 1999 ; Serdar et al, 2006 ). However, data on Cu status throughout normal pregnancies as well as early preeclamptic pregnancies is inadequate, and it remains unclear whether Cu deficiency is a public health problem (Arredondo and Nunez, 2005 ).…”

Section: Antioxidant Protective Systemsmentioning

confidence: 99%

Oxidative stress in preeclampsia and the role of free fetal hemoglobin

2015

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Preeclampsia is a leading cause of pregnancy complications and affects 3–7% of pregnant women. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on hemoglobin-induced oxidative stress. Furthermore, we also suggest hemoglobin as a potential target for therapy. Gene and protein profiling studies have shown increased expression and accumulation of free fetal hemoglobin in the preeclamptic placenta. Predominantly due to oxidative damage to the placental barrier, fetal hemoglobin leaks over to the maternal circulation. Free hemoglobin and its metabolites are toxic in several ways; (a) ferrous hemoglobin (Fe2+) binds strongly to the vasodilator nitric oxide (NO) and reduces the availability of free NO, which results in vasoconstriction, (b) hemoglobin (Fe2+) with bound oxygen spontaneously generates free oxygen radicals, and (c) the heme groups create an inflammatory response by inducing activation of neutrophils and cytokine production. The endogenous protein α1-microglobulin, with radical and heme binding properties, has shown both ex vivo and in vivo to have the ability to counteract free hemoglobin-induced placental and kidney damage. Oxidative stress in general, and more specifically fetal hemoglobin-induced oxidative stress, could play a key role in the pathology of preeclampsia seen both in the placenta and ultimately in the maternal endothelium.

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“…Some studies have indicated that decreased zinc concentrations collaborated with fetal malformations, fetus growth restriction, preterm delivery, preeclampsia, and bleeding after delivery [ 27 , 28 ]. Serum or placental Zn levels have shown to be low [ 7 , 29 ] or without change [ 30 , 31 ] in preeclampsia women. It has been revealed that concentrations of zinc and copper reduced in preeclampsia patients [ 18 , 32 ] while study of Ugwuja et al .…”

Section: Introductionmentioning

confidence: 99%

Serum Copper, Zinc and Lipid Peroxidation in Pregnant Women with Preeclampsia in Gorgan

Rafeeinia

Tabandeh

Khajeniazi

et al. 2014

TOBIOCJ

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The aim of study was to assay serum copper, zinc and lipid peroxidation levels in pregnant women with and without preeclampsia. There were significant differences between systolic, diastolic blood pressures and copper, Cu/Zn ratio and malondialdehyde among two groups. There were significant differences in weight, pre-pregnancy body mass index, systolic, diastolic blood pressures and copper, Cu/Zn ratio and malondialdehyde levels when compared to healthy pregnant women with mild and severe preeclampsia patients. A positive correlation was observed between systolic and diastolic blood pressure and copper, malondialdehyde and Cu/Zn ratio. Copper and malondialdehyde may play a role in the pathophysiology of preeclampsia.

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Elevated copper and lowered zinc in the placentae of pre-eclamptics

Cited by 32 publications

References 8 publications

The Importance of Antioxidant Micronutrients in Pregnancy

The Importance of Antioxidant Micronutrients in Pregnancy

Oxidative stress in preeclampsia and the role of free fetal hemoglobin

Serum Copper, Zinc and Lipid Peroxidation in Pregnant Women with Preeclampsia in Gorgan

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