Elevated expression of toll-like receptor 4 is associated with NADPH oxidase-induced oxidative stress in B cells of children with autism

Al-Harbi, Naif O.; Nadeem, Ahmed; Ahmad, Sheikh F.; Al-Ayadhi, Laila; Al-Harbi, M. M.; Sobeai, Homood M. As; Ibrahim, Khalid E.; Bakheet, Saleh A.

doi:10.1016/j.intimp.2020.106555

Cited by 25 publications

(10 citation statements)

References 51 publications

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“…Histopathological obsevations in OM‐intoxicated rats showed that the normal histology of both liver and kidney was altered due to the presence of ROS; a similar feature was observed in a previous study performed on other substance such as CCL4, whose metabolites produce ROS (Otrubova et al, 2018) and other various disorders (Al‐Harbi et al, 2019; Al‐Harbi, Nadeem, Ahmad, Al‐Ayadhi, et al, 2020; Al‐Harbi, Nadeem, Ahmad, Bakheet, et al, 2020; Nadeem et al, 2020). One study reported that the central lobe of the liver was degenerated by a high dose of Stanozolol, one of the anabolic androgen steroids (Boada et al, 1999).…”

Section: Discussionsupporting

confidence: 76%

“…Histopathological obsevations in OM-intoxicated rats showed that the normal histology of both liver and kidney was altered due to the presence of ROS; a similar feature was observed in a previous study performed on other substance such as CCL4, whose metabolites produce ROS (Otrubova et al, 2018) and other various disorders (Al-Harbi et al, 2019;Al-Harbi, Nadeem, Ahmad, Al-Ayadhi, et al, 2020;Nadeem et al, 2020).…”

Section: Histopathologic Findingssupporting

confidence: 80%

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Renoprotective and hepatoprotective activity of Lepidium draba L. extracts on oxymetholone‐induced oxidative stress in rat

Feng

Gao

Yang

et al. 2022

Journal of Food Biochemistry

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Section: Discussionsupporting

confidence: 76%

Section: Histopathologic Findingssupporting

confidence: 80%

Renoprotective and hepatoprotective activity of Lepidium draba L. extracts on oxymetholone‐induced oxidative stress in rat

Feng

Gao

Yang

et al. 2022

Journal of Food Biochemistry

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“…Even though it is difficult to know whether the connection is unique to specific brain regions or not due to the limitations of the brain tissue sample, this has revealed more about the role of oxidative stress in the etiology of ASD. Other studies in peripheral blood cells have found evidence of inflammation and oxidative stress in a variety of cell types, including T cells ( 86 , 87 ), B cells ( 88 ), monocytes ( 89 , 90 ), neutrophils ( 90 ), and lymphocytes ( 91 ). In these studies, in vitro induction experiments were also used to demonstrate the link between inflammation and oxidative stress in peripheral cells.…”

Section: Oxidative Stress and Asdmentioning

confidence: 98%

Oxidative Stress in Autism Spectrum Disorder—Current Progress of Mechanisms and Biomarkers

et al. 2022

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Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been diagnosed in an increasing number of children around the world. Existing data suggest that early diagnosis and intervention can improve ASD outcomes. However, the causes of ASD remain complex and unclear, and there are currently no clinical biomarkers for autism spectrum disorder. More mechanisms and biomarkers of autism have been found with the development of advanced technology such as mass spectrometry. Many recent studies have found a link between ASD and elevated oxidative stress, which may play a role in its development. ASD is caused by oxidative stress in several ways, including protein post-translational changes (e.g., carbonylation), abnormal metabolism (e.g., lipid peroxidation), and toxic buildup [e.g., reactive oxygen species (ROS)]. To detect elevated oxidative stress in ASD, various biomarkers have been developed and employed. This article summarizes recent studies about the mechanisms and biomarkers of oxidative stress. Potential biomarkers identified in this study could be used for early diagnosis and evaluation of ASD intervention, as well as to inform and target ASD pharmacological or nutritional treatment interventions.

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“…Pattern recognition receptor (PRR) CR3 and TLR4 signaling by damage associated molecular patterns (DAMPs), such as high mobility group box 1 (HMGB1) released by damaged neurons, is linked to NOX2 expression and activation in microglia ( Pei et al, 2007 ; Gao et al, 2011 ; Bell et al, 2013 ; Hou et al, 2018 ). The inhibition of NF-KB signaling has been shown to reduce LPS induced NOX and inducible nitric oxide synthase (iNOS) expression in various peripheral cell types ( Kim B et al, 2008 ; Al-Harbi et al, 2020 ; Sul and Ra, 2021 ). NOX-mediated aberrant ROS production in response to proinflammatory signaling is a major source of oxidative stress in epilepsy, and is further linked to interictal glucose hypometabolism ( Malkov et al, 2018 ).…”

Section: Neuroinflammatory Induction Of Oxidative Stressmentioning

confidence: 99%

Crosstalk between neuroinflammation and oxidative stress in epilepsy

Fabisiak

Patel²

2022

Front. Cell Dev. Biol.

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The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy have begun to receive considerable attention in recent years. However, these concepts are predominantly studied as separate entities despite the evidence that neuroinflammatory and redox-based signaling cascades have significant crosstalk. Oxidative post-translational modifications have been demonstrated to directly influence the function of key neuroinflammatory mediators. Neuroinflammation can further be controlled on the transcriptional level as the transcriptional regulators NF-KB and nrf2 are activated by reactive oxygen species. Further, neuroinflammation can induce the increased expression and activity of NADPH oxidase, leading to a highly oxidative environment. These factors additionally influence mitochondria function and the metabolic status of neurons and glia, which are already metabolically stressed in epilepsy. Given the implication of this relationship to disease pathology, this review explores the numerous mechanisms by which neuroinflammation and oxidative stress influence one another in the context of epilepsy. We further examine the efficacy of treatments targeting oxidative stress and redox regulation in animal and human epilepsies in the literature that warrant further investigation. Treatment approaches aimed at rectifying oxidative stress and aberrant redox signaling may enable control of neuroinflammation and improve patient outcomes.

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Elevated expression of toll-like receptor 4 is associated with NADPH oxidase-induced oxidative stress in B cells of children with autism

Cited by 25 publications

References 51 publications

Renoprotective and hepatoprotective activity of Lepidium draba L. extracts on oxymetholone‐induced oxidative stress in rat

Renoprotective and hepatoprotective activity of Lepidium draba L. extracts on oxymetholone‐induced oxidative stress in rat

Oxidative Stress in Autism Spectrum Disorder—Current Progress of Mechanisms and Biomarkers

Crosstalk between neuroinflammation and oxidative stress in epilepsy

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