Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease

Bakeberg, Megan C.; Gorecki, Anastazja M.; Kenna, Jade; Jefferson, Alexa; Byrnes, Michelle; Ghosh, Soumya; Horne, Malcolm; McGregor, S. Elizabeth; Stell, Rick; Walters, Sue; Mastaglia, Frank; Anderton, Ryan S.

doi:10.3389/fnagi.2021.656623

Cited by 15 publications

(12 citation statements)

References 98 publications

(133 reference statements)

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“…Our study also found that females have higher serum TC, LDL-C, and HDL-C levels than males in PD, which were in line with previous studies [ 10 , 36 ]. Furthermore, we compared the serum Apo-A1 and Apo-B levels between sexes in PD for the first time, and females showed higher Apo-A1 and Apo-B levels in PD.…”

Section: Discussionsupporting

confidence: 93%

“…Studies reported that higher serum TG levels were associated with PD with mild cognitive impairment [ 8 ] and lower anxiety levels [ 9 ]. Another study showed that compared to males with PD, females with PD had higher serum HDL-C levels, which were potentially associated with poorer cognition performance [ 10 ]. However, Choe et al found that no lipid fraction was significantly associated with motor and cognitive function in PD patients in a cross-sectional analysis of the Biomarkers in Parkinson’s Disease (Mark-PD) study [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Lower serum triglyceride levels linked to more severe motor performance in Parkinson’s disease

et al. 2022

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Introduction Emerging evidence has suggested that lipid metabolism is correlated with Parkinson’s disease (PD) onset and progression. However, the effect of lipid metabolism on motor performance in PD patients is still unknown. This study estimated the association between lipid profiles and the severity of motor performance in PD. Methods This cross-sectional study enrolled 279 idiopathic PD patients from the Department of Neurology of Beijing Tiantan Hospital from May 2016 to August 2018. Serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and apolipoprotein B (Apo-B) levels were detected in fast serum samples. Motor performance was assessed by Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III (MDS-UPDRS III) total scores and subscores in these patients. The associations of lipid profiles with motor performance were analyzed using multivariable linear regression models. Results Compared to males, females with PD exhibited significantly higher serum TC, LDL-C, HDL-C, Apo-A1, and Apo-B levels. When accounting for covariates, lower serum TG levels were significantly associated with higher MDS-UPDRS III total scores and gait/postural instability subscores. Additionally, the univariate linear regression model showed that in males with PD, serum HDL-C or Apo-A1 levels were significantly associated with tremor subscores. Conclusion Lower serum TG levels were associated with more severe motor performance in patients with PD and TG may be a potential predictive biomarker for motor performance in PD patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Lower serum triglyceride levels linked to more severe motor performance in Parkinson’s disease

et al. 2022

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“…Consistently to previous findings (Sterling et al 2016;Bakeberg et al 2021), the women of the PACOS cohort showed higher TC, HDL and LDL serum levels than men. However, while Bekeberg et al (2021) reported a strong association between high HDL levels and cognitive impairment (including attentive and executive functioning), in women with PD but not in men, in the PACOS cohort HDL was not associated with executive functioning neither in the whole sample, nor in the sample stratified by sex.…”

Section: Discussionsupporting

confidence: 91%

“…Although not entirely consistent, some studies suggested that subjects with high levels of cholesterol and low-density lipoproteins have a lower PD risk, thus supporting the role of statins as a risk factor for PD (Potashkin et al 2020;Fu et al 2020). To date only few studies have investigated the effects of dyslipidemia on cognitive performance in PD, reporting conflicting results (Choe et al 2021;Huang et al 2018;Mollenhauer et al 2019;Bakeberg et al 2021). Furthermore, most of the existing studies did not consider the sex-specific differences when evaluating possible associations between lipids levels and cognition.…”

Section: Introductionmentioning

confidence: 99%

Executive functioning and serum lipid fractions in Parkinson’s disease—a possible sex-effect: the PACOS study

et al. 2022

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The association between dyslipidemia and cognitive performance in Parkinson’s disease (PD) patients still needs to be clarified. Aim of the study was to evaluate the presence of possible associations between serum lipids fractions and executive dysfunction also exploring the sex-specific contribute of lipids level on cognition. Patients from the PACOS cohort, who underwent a complete serum lipid profile measures (total cholesterol-TC, low-density lipoprotein cholesterol-LDL, high-density lipoprotein cholesterol-HDL and triglycerides-TG) were selected. Adult Treatment Panel III guidelines of the National Cholesterol Education Program were used to classify normal/abnormal lipid fractions. Executive functioning was assessed with the Frontal Assessment Battery (FAB). Logistic regression was performed to assess associations between lipids fractions and FAB score. Correlations between lipids fractions and FAB score were explored. Sex-stratified analysis was performed. Three hundred and forty-eight PD patients (148 women; age 66.5 ± 9.5 years; disease duration 3.9 ± 4.9 years) were enrolled. Women presented significantly higher TC, LDL and HDL than men. In the whole sample, any association between lipid profile measures and FAB score was found. Among women, a positive association between hypertriglyceridemia and FAB score under cutoff was found (OR 3.4; 95%CI 1.29–9.03; p value 0.013). A statistically significant negative correlation was found between the FAB score and triglyceride serum levels (r = − 0.226; p value 0.005). Differently, among men, a statistically significant negative association between hypercholesterolemia and FAB score under cutoff (OR 0.4; 95%CI 0.17–0.84; p value 0.018) and between high LDL levels and FAB score under cutoff (OR 0.4; 95%CI 0.18–0.90; p value 0.027) were found. Our data suggest a sex-specific different role of lipids in executive functioning.

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“…In our previous community cohort study, a longitudinal increase of NHDL-C is protective of cognition ( 18 ). Moreover, a study explored the association between cholesterol levels and cognitive function in patients with Parkinson’s disease and found that higher serum HDL-C is associated with poorer cognitive function ( 32 ), which coincides with our result in younger patients. Another longitudinal cohort study did not find any significant associations between HDL-C and cognitive impairment ( 33 ).…”

Section: Discussionsupporting

confidence: 88%

Association between lipid metabolism and cognitive function in patients with schizophrenia

Liu

Huang

Zhang³

et al. 2022

Front. Psychiatry

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BackgroundThe association between blood lipids and cognitive function in schizophrenia is still controversial. Thus, the present study aimed to verify the association between various lipid parameters and cognitive impairment in schizophrenic patients and potential lipid pathways.MethodsA total of 447 adult inpatients with schizophrenia were divided into cognitive normal and cognitive impairment groups based on the Mini-Mental State Examination with a cut-off of 26. The blood lipid parameters were defined as abnormal levels based on the guideline. The liquid chromatography-mass spectrometry method was used to preliminarily explore the potential lipid metabolism pathway associated with cognitive impairment.ResultsThere were 368 (82.3%) patients who had cognitive impairment. Herein, apolipoprotein B was positively associated with cognitive function in overall patients and age (≥45 and <45 years) and sex subgroups. After excluding patients with hypertension and diabetes, ApoB was still significantly associated with cognitive function in all the patients. The associations between other lipid parameters, including non-high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride, and cognitive impairment were heterogeneous in age and sex subgroups. In contrast, total cholesterol and apolipoprotein A1 were not significantly associated with cognitive impairment. Metabolomics analysis showed that metabolic pathway mainly involved sphingolipid metabolism. Meanwhile, sphinganine and 3-dehydrosphinganine were positively correlated with lipid parameters and decreased in patients with cognitive impairment as compared to those with normal cognition.ConclusionsThe present study suggests a positive association between lipids and cognitive function in schizophrenic patients and needs to be further verified by a prospective study.

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Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease

Cited by 15 publications

References 98 publications

Lower serum triglyceride levels linked to more severe motor performance in Parkinson’s disease

Lower serum triglyceride levels linked to more severe motor performance in Parkinson’s disease

Executive functioning and serum lipid fractions in Parkinson’s disease—a possible sex-effect: the PACOS study

Association between lipid metabolism and cognitive function in patients with schizophrenia

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