Elevated levels of MCP-1, MIP-α and MIP-1β in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis

Emad, Ali; Emad, Vahid

doi:10.1016/j.tox.2007.07.014

Cited by 54 publications

(30 citation statements)

References 31 publications

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“…CCL3 and CCL5 are important chemokines of airway hyperresponsiveness; in contrast, the role of CCL4 in asthma is uncertain. However, there are some reports of higher levels of this cytokine in several pulmonary conditions, such as chronic bronchitis [9], pulmonary fibrosis [14], and cystic fibrosis [15].…”

Section: Discussionmentioning

confidence: 99%

“…Levels of CCL4 are increased in alcoholic liver disease [9], glomerulonephritis, acute renal transplant rejection [10], human sepsis [11], and advanced atherosclerosis lesions [12]. There are no reports regarding the role of CCL4 in asthma disease but there are some observations of higher levels of this cytokine in several pulmonary conditions such as chronic bronchitis [13], pulmonary fibrosis [14], and cystic fibrosis [15].…”

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confidence: 99%

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CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

Velázquez¹,

Soid-Raggi²,

Terán³

et al. 2017

Health

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Aspirin-exacerbated respiratory disease (AERD) is an asthma phenotype characterized by nasal polyps, chronic hypertrophic eosinophilic sinusitis, asthma, and sensitivity to aspirin. Unawareness of this disease by patients and their physicians may have serious consequences because of the risk of near-fatal asthma. Its confirmative diagnosis can be established only by provocative aspirin challenge, which represents a potential risk for patient health. Purpose: Because CCL4 plays an important role in several pulmonary conditions, we tested its immunoreactivity in nasal lavages and sera from control subjects, and from aspirin-sensitive and non-aspirin-sensitive patients. Method: Immunoreactivity of CCL4 was measured in serum and nasal lavages from 30 healthy controls (HC), 23 patients with AERD, and 20 patients with aspirin-tolerant asthma (ATA). Additionally, a serum biobank contained sera from 90 HC, 83 patients with AERD, and 69 patients with ATA was employed. Results: The serum immunoreactivity of CCL4 could distinguish both types of asthma phenotypes. Conclusion: CCL4 may play an unexpected role in thephysiopathology of AERD.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

Velázquez¹,

Soid-Raggi²,

Terán³

et al. 2017

Health

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“…Effects of age and gender on serum CCL2 and CXCL8 concentrations were not significant. In humans, both CXCL8 and CCL2 concentrations were found to be increased in blood (Ziegenhagen et al, 1998a;Suga et al, 1999;Fujiwara et al, 2012) and bronchoalveolar lavage fluid (BALF) (Capelli et al, 2005;Antoniou et al, 2006;Baran et al, 2007) of IPF patients compared with healthy volunteers and correlated with lung function (Capelli et al, 2005;Emad and Emad, 2007;Martina et al, 2009;Vasakova et al, 2009), disease progression (Ziegenhagen et al, 1998b;Totani et al, 2002), and outcome (Shinoda et al, 2009;Richards et al, 2012). Furthermore, several studies suggested an involvement of the chemokine CCL2 in the pathogenesis of IPF, notably through its action on resident pulmonary fibroblast and circulating fibrocytes, promoting the generation of abundant extracellular matrix in the lungs (Gharaee-Kermani et al, 1996;Phillips et al, 2004;Moore et al, 2005;Inomata et al, 2014).…”

Section: Cxcl8 and Ccl2 Concentrationsmentioning

confidence: 99%

Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis

Roels

Krafft

Antoine

et al. 2015

Research in Veterinary Science

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The West Highland white terrier (WHWT) is particularly prone to canine idiopathic pulmonary fibrosis (CIPF). We hypothesized that higher circulating concentrations of chemokines CXCL8, CCL2, serotonin (5-HT), or vascular endothelial growth factor (VEGF) could serve as predisposing factors for CIPF development in the WHWT breed. Serum samples from 103 healthy dogs of seven different breeds variably predisposed to CIPF were collected. Serum CXCL8 concentrations were higher in healthy WHWT compared with each of the other groups of healthy dogs. Serum CCL2 concentrations were higher in healthy WHWT and Maltese compared with King Charles spaniels and Malinois Belgian shepherds. No relevant inter-breed differences were observed for serum 5-HT concentrations regarding CIPF predisposition. VEGF values from 89.3% of samples tested were below the kit detection limit. In conclusion, high CXCL8 blood concentrations and possibly CCL2 concentrations might be related to the breed predisposition of the WHWT for CIPF and warrants further investigations.

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“…During the Iraq and Iran war, Iraq used chemical weapons almost 260 times, and more than 5000 Iranian soldiers were exposed to poisoning chemicals, especially the mustard gas (33,34). Many studies mentioned that symptoms and signs of soldiers imply immunologic and inflammatory mechanisms (5,30,(34)(35)(36), yet others mentioned that molecular patterns should be concerned in these patients. Life style, psychiatric parameters, and socioeconomic status are some factors affected by these clinical complications.…”

Section: Discussionmentioning

confidence: 99%

“…Sulphur Mustard exposure could cause laryngitis, tracheobronchitis, bronchiolitis, obliterans, bronchopneumonia, chronic obstructive pulmonary disease (COPD), bronchiectasis, asthma, and large airway narrowing (28)(29)(30). The mechanisms that underlie these SM-induced respiratory lesions, however, are unknown.…”

Section: Symptoms and Clinical Manifestationsmentioning

confidence: 99%

Effects of Mustard Gas on Veterans: A Review

Jahromy

Mohsenian

Rezagholizamenjany

et al. 2017

Ann Mil Health Sci Res

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Context: Sulfur Mustard has been an important subject of research for Iranian scientists since 1983, when the Iraq army used this chemical weapon against Iranians, causing injury for more than 30000 people, still suffering from its late effects.Evidence Acquisition: This review was based on previous studies, found from online databases. Results: Sulfur mustard is synthesized by different methods, and its exposure could cause severe, irreversible damage to the skin, respiratory tract, and eyes. In the eyes, it has a wide spectrum of complications. These complications begin with an asymptomatic period, following irritation and redness, and ends with damage to the corneal structure with photophobia, temporary blindness, and blepharospasm.Conclusions: Based on this, this review discusses some of the attempts made to define aspects of sulfur mustard and its mechanisms.

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Elevated levels of MCP-1, MIP-α and MIP-1β in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis

Cited by 54 publications

References 31 publications

CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

CCL4 Levels Differ between Aspirin-Tolerant and Aspirin-Intolerant Patients with Asthma

Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis

Effects of Mustard Gas on Veterans: A Review

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