Elevated neutrophil lymphocyte ratio in patients with substance use disorders

Abstract

IntroductionDisturbances in inflammatory processes may play a role in the pathophysiology of psychiatric disorders. The neutrophil lymphocyte ratio (NLR) and C-reactive protein (CRP) are indicators of the systemic inflammatory response.ObjectivesThe current study was prepared based on the assumption that dysregulated immune function and elevated inflammation markers may be seen in substance use disorders.AimsOur aim was to investigate whether NLR and CRP are higher in patients diagnosed with substance use disorders than in healthy subjects.MethodsThe participants in the study included 115 male inpatients diagnosed with alcohol (n = 41), heroin (n = 46), or synthetic cannabinoid (n = 28) dependence according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV-TR), and 32 healthy male volunteers. We used NLR and CRP as measures of systemic inflammation. Blood samples were taken on the next morning of admission for detoxification. Addiction severity was assessed using the Addiction Profile Index (API).ResultsThe difference between the groups with respect to NLR was statistically significant (P = 0.014). Patients diagnosed with alcohol, heroin or synthetic cannabinoid dependence had similar NLR. Patients with alcohol or synthetic cannabinoid dependence had significantly higher NLR than healthy controls (P = 0.001 and P = 0.029, respectively). Patients with heroin dependence trended towards statistically significantly higher NLR compared to healthy controls (P = 0.067). CRP levels did not differ significantly between the patient and control groups. NLR and CRP were not significantly correlated with API scores.ConclusionsOur findings suggest that NLR is elevated in patients with substance use disorders in comparison to healthy controls.Disclosure of interestThe authors have not supplied their declaration of competing interest.

A comparative study of complete blood count inflammatory markers in substance‐free acute psychotic disorder and substance‐induced psychosis

“…A recent study showed that half of FEP patients had co‐occurring substance use disorders, and substance use has been repeatedly reported to contribute to the development of psychosis with adverse outcomes (Brunette et al, 2018; Kraan et al, 2016; Schoeler et al, 2016). Similarly, there are some reports that support the hypothesis that inflammatory pathways might be related to substance use disorders (Ozkan et al, 2017; Uys, Mulholland, & Townsend, 2014; Womersley, Townsend, Kalivas, & Uys, 2019). Considering previous findings that support the involvement of inflammatory pathways in both psychosis and substance‐related disorders, we assumed there might be relatively more specific CBC inflammatory markers when comparing substance‐related and substance‐free psychotic conditions, particularly for acute courses of illness.…”

Inflammation levels in patients with alcohol and substance use disorders

“…Nötrofil/lenfosit oranı (NLO), Monosit/lenfosit (MLO) ve Platelet/lenfosit oranı (PLO) değerleri tam kan sayımı sonuçlarından manuel olarak hesaplanmıştır. Literatürde AKB ve MKB hastalarında inflamasyon belirteçlerinin incelendiği çalışmalarda elde edilen sonuçlar çelişkili olmuştur 14,16,20,21,[23][24][25][26][27][28][29] . Yapılan bir çalışmada alkol, sentetik kannabinoid ve eroin kullanım bozukluğu hastalarının NLO ve C-reaktif Protein (CRP) değeri karşılaştırılmıştır.…”

“…Yapılan bir çalışmada alkol, sentetik kannabinoid ve eroin kullanım bozukluğu hastalarının NLO ve C-reaktif Protein (CRP) değeri karşılaştırılmıştır. Elde edilen sonuçlarda üç hasta grubunun da; NLO sağlıklı kontrollerden yüksek olarak hesap edilmiştir 24 . AKB hastalarında NLO yüksekliğinin alkolik karaciğer hastalığı ve diğer alkol ile ilişkili komplikasyonlar ile bağlantılı olduğu bildirilmiştir 25 .…”

Evaluation of Neonatal Abstinence Syndrome (Nas) Frequency and Systemic Inflammatory Response in Nas

“…Yasa dışı ilaç bağımlısı kişilerde inflamasyonun ve inflamatuvar yanıtın arttığı görülmektedir (8). Güncel bir çalışmada yasa dışı ilaç bağımlılarında NLO kontrol grubuna göre arttığı ve inflamasyonu gösterdiği bildirilmiştir (23). Bizim çalışmamızda da NLO' nın NYS grubunda yüksek olduğu, bu yüksekliğin tedavi edilen hastalarda teda-…”