Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

Abstract

Objective. Th e neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic infl ammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group.Methods. A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls. Th e CAT patients were similar in age to the healthy control group (mean 33.9±12.8 years versus 30.2±12.4 years, p=0.10). Measurements were available for the white blood cells (WBC), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), thyroid peroxidase immune antibody (anti-TPO), and anti-thyroglobulin immune antibody (anti-TG). Th e NLR and platelet-lymphocyte ratio (PLR) were calculated. Diff erences between the CAT and control groups were tested using the student's t-test and the correlations were determined using Pearson's correlation coeffi cients.Results. Th ere were no diff erences between the CAT and control groups for WBCs (7.9±0.3 and 7.4±0.2, respectively; p=0.1) or neutrophils (5.5±0.3 and 5.4±1.1; p=0.9), but lymphocytes were higher in the CAT group (3.1±0.5 vs. 2.04±0.1; p=0.05) as was the NLR (4.0±0.7 vs. 2.0±0.1; p=0.01). Th e NLR was positively correlated with CRP (r=0.6, p<0.001), anti-TPO (r=0.3, p<0.001), anti-TG (r=0.3, p=0.006), WBCs (r=0.4, p<0.001), and the PLR (r=0.73, p<0.001). Th e PLR was also higher in the CAT than the control group (p=0.02).Conclusions. In this study, we found that NLR values were higher in euthyroid CAT patients than in a healthy control group and that NLR correlated with autoantibodies used to diagnose the disease.

Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto’s Thyroiditis

“…The changes in NLR and PLR found in our study indicate that the inflammation might be not only limited to a single organ but also reflect the state of chronic systemic inflammation in HT. Recently, a number of studies have explored the significance of NLR and PLR in assessment of inflammation in HT patients (16,17). Similar to our study results, Keskin et al found that NLR and PLR are higher in patients with euthyroid HT without any replacement therapy [16].…”

“…Recently, a number of studies have explored the significance of NLR and PLR in assessment of inflammation in HT patients (16,17). Similar to our study results, Keskin et al found that NLR and PLR are higher in patients with euthyroid HT without any replacement therapy [16]. NLR and PLR were increased in numerous studies in patients with rheumatoid arthritis, systemic lupus erythematosus, familial Mediterranean fever, ulcerative colitis (UC) and psoriasis [3][4][5][6]18].…”

The Evaluation of Neutrophil to Lymphocyte ratio and mean platelet volume in patients with active and inactive thyroid orbitopathy

“…NLO'nun özellikle papiller tiroid kanseri olmak üzere farklı tiroid kanserleriyle ilişkili olduğunu göste-ren çalışmalar mevcuttur. [9][10][11][12] Örneğin Koçer ve arkadaşları papiller tiroid kanseri ile çeşitli iyi huylu tiroid hastalıkların-da NLO'yu araştırmış ve papiller tiroid kanserli hastalarda anlamlı yüksek saptamıştır. Onlar NLO'nun iyi huylu ve kötü huylu tiroid hastalıklarının ayrımında bir fikir verebileceği-ni savunmaktadır.…”

“…Keskin ve arkadaşlarının yaptıkları çalışmada ötiroid kronik otoimmün tiroiditli hastalarda periferik kanda NLO'nun kontrol grubuna kıyasla arttığı ve tiroid antikorları ile ilişkili olduğu gös-terilmiştir. [11] Oküler hastalıklar sistemik inflamasyondan ziyade lokal bir inflamatuar yanıta neden olmasına rağmen NLO'nun yaşa bağlı makular dejenerasyon, retinal ven tıkanıklığı, non-arteritik anterior iskemik optik nöropati, vernal keratokonjonktivit, kuru göz ve primer açık açılı glokom gibi çeşitli göz hastalıklarında ilişkili olduğu saptanmış-tır. [25][26][27][28][29][30][31] NLO'nun lokal inflamatuar hastalıklarda anlamlı olabilmesi için sistemik kan parametrelerinde değişiklik yapması gerekir.…”

“…Bazı diğer kanser türlerinde olduğu gibi çeşitli tiroid kanserlerinde NLO'nun arttığına dair çalışmalar vardır. [9][10][11][12] . Ancak TO'nun tam kan sayımı ile ilişkisine dair bir çalışma yoktur.…”